|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that PACAP is not involved in the regulation of expression of TH in neuroblastomas.
|
15518890 |
2004 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We used embryonal carcinoma (EC) and neuroblastoma (NB) cell lines and found that lovastatin promoted apoptosis and induced expression of the neuronal differentiation markers, tyrosine hydroxylase (TH), and growth-associated protein 43.
|
20694854 |
2010 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
BM aspirates, trephine biopsies, PB, and peripheral blood stem cell (PBSC) samples from Italian children with neuroblastoma were analyzed by morphological and histologic techniques, as well as by immunocytochemistry (IC) for disialoganglioside GD(2) and reverse transcription-PCRs (RT-PCRs) for tyrosine hydroxylase (TH) and pgp9.5 genes.
|
15585633 |
2004 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether detection of minimal residual disease (MRD) in peripheral blood stem cells (PBSC) by using tyrosine hydroxylase (TH) expression could predict outcome of patients with advanced neuroblastoma.
|
19125082 |
2009 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, THp was chosen for a neuroblastoma-selective suicide gene therapy approach using the herpes simplex virus type 1 thymidine kinase (HSV-tk)/ganciclovir (GCV) system.
|
15181182 |
2004 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Neuroblastoma cell detection by reverse transcriptase-polymerase chain reaction (RT-PCR) for tyrosine hydroxylase mRNA.
|
7910809 |
1994 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Quantitative analysis of tyrosine hydroxylase mRNA in blood and bone marrow is reliable and easy to perform and may be used for upfront staging, prognostic assessment, and treatment monitoring of neuroblastoma.
|
12507966 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Analysis in an inducible neuroblastoma cell culture model demonstrated altered tyrosine hydroxylase activity in the presence of the mutant but not wildtype torsinA protein.
|
19761814 |
2009 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of the tyrosine hydroxylase gene (TH) is regulated in a tissue-specific manner during neonatal development and differentiation, therefore TH mRNA expression is a specific tumour marker for NB.
|
12579272 |
2003 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Flow cytometry (FCM) with CD45/CD56/CD81 and reverse transcriptase-polymerase chain reactions (RT-PCR) for tyrosine hydroxylase (TH) transcripts were used to evaluate neuroblastoma in bilateral BM aspirates at diagnosis, BM autografts, peripheral blood stem cell (PBSC) collections, and CD34(+) cell products of 27 children.
|
12767104 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Regulation of tyrosine hydroxylase gene expression in IMR-32 neuroblastoma cells by basic fibroblast growth factor and ciliary neurotrophic factor.
|
7760021 |
1995 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that etoposide can be designed as a prodrug substrate for tyrosine hydroxylase and thereby establish proof of concept for neuroblastoma directed enzyme prodrug therapy.
|
12880985 |
2003 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this prospective, multicenter study, the independent prognostic power of neuroblastoma cells detected by reverse transcriptase polymerase chain reaction (RT-PCR) for tyrosine hydroxylase (TH) mRNA was evaluated.
|
11251011 |
2001 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We examined effects of the selective norepinephrine-transporter (NET) inhibitor antidepressant desipramine (DMI) on expression of TH in human neuroblastoma cells (SK-N-BE[2]M17) and in rat brain regions.
|
15710233 |
2005 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sensitivities of TH nPCR determined with a number of neuroblastoma cell lines and PBSCs correlated to cell line dependent basal TH gene expression levels and ranged from 1:10(4) to 1:10(6).
|
9516847 |
1997 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicate that GDNF up-regulates the expression of the TH gene by promoting the transcription of the TH gene and the stability of TH mRNA with the Ret receptor dependency in some neuroblastoma cell lines.
|
12358785 |
2002 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As high expression of PGP 9.5 was only found in neural tumors; PGP 9.5 expression by ES provides further evidence for a neural origin of this tumor, whereas TH expression is highly specific for neuroblastomas.
|
10690538 |
2000 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
New splicing variants for human Tyrosine Hydroxylase gene with possible implications for the detection of minimal residual disease in patients with neuroblastoma.
|
12493595 |
2003 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults.
|
19815691 |
2010 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The expressed recombinant PTD-TH with a molecular weight of 61 kD was successfully transduced (1 microM) into the dopaminergic SH-sy5y human neuroblastoma cells in vitro and visualized by immunohistochemical assay.
|
16762325 |
2006 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
As almost all patients with high-risk neuroblastomas have autograft, we aimed to determine if minimal residual disease (MRD) quantified by RT-PCR for tyrosine hydroxylase in PBSC is prognostic in neuroblastomas.
|
23596146 |
2013 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tyrosine hydroxylase and 3,4-dihydroxyphenylalanine (dopa) decarboxylase transcripts were demonstrated in 10 of 13 cases of neuroblastoma.
|
20231617 |
2010 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of the neuroendocrine protein gene product 9.5 (PGP9.5) and tyrosine hydroxylase (TH) mRNA in BM and PB obtained from 18 patients with NB was investigated by reverse transcriptase-polymerase chain reaction (RT-PCR).
|
11051140 |
2000 |
|
Neuroblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Seven NB cell lines and 30 bone marrow (BM) samples from patients with high-risk NB were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR) for MYCN expression, and for the established NB marker tyrosine hydroxylase.
|
17023822 |
2006 |
|
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overexpression of the human MYCN oncogene driven by a tyrosine hydroxylase promoter causes tumours in transgenic mice that recapitulate the childhood cancer neuroblastoma.
|
17449239 |
2007 |