|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.
|
12232779 |
2002 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Given a presumed role for norepinephrine (NE) in bipolar disorder, as well as the actions of mood-stabilizing drugs, we examined changes in mRNA expression for tyrosine hydroxylase (TH), the NE transporter (NET) and alpha 2A autoreceptor in the rat locus coeruleus after valproate treatment.
|
10633488 |
2000 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We attempted to test the hypothesis that there was allelic association between polymorphisms around the tyrosine hydroxylase locus and bipolar affective disorder.
|
10616951 |
1999 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The results of this association study do not confirm the possible implication of TH polymorphism in the susceptibility to BPAD.
|
10490711 |
1999 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results.
|
10050974 |
1999 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We attempted to test the hypothesis that there was allelic association between polymorphisms around the tyrosine hydroxylase locus and bipolar affective disorder.
|
10616951 |
1999 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
While positive associations between TH and bipolar affective disorder have been found in several studies, many studies have failed to reproduce these results.
|
10050974 |
1999 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of this association study do not confirm the possible implication of TH polymorphism in the susceptibility to BPAD.
|
10490711 |
1999 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Linkage and association studies have implicated the involvement of the tyrosine hydroxylase (TH) gene on chromosome 11p15 in schizophrenia and bipolar disorder (BPD).
|
9686421 |
1998 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Manic depressive illness and tyrosine hydroxylase gene: linkage heterogeneity and association.
|
9440122 |
1997 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, the hypothesis that the tyrosine hydroxylase and the dopamine D4 receptor genes may be involved in the etiology of bipolar disorder and unipolar recurrent major depression is not supported in our study.
|
9129719 |
1997 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Test of the null hypothesis that the mean log odds ratio equals zero (chi2 = 0.11; 5 df; P > 0.05) indicated that there was no overall association between bipolar disorder and tyrosine hydroxylase.
|
9259367 |
1997 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cladistic analysis of disease association with tyrosine hydroxylase: application to manic-depressive disease and alcoholism.
|
9184313 |
1997 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain, including manic-depressive illness and schizophrenia.
|
8984738 |
1996 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results provide some support for linking affective disorder to this genetic region and suggest that additional linkage and association studies should be conducted to determine whether tyrosine hydroxylase or a nearby locus contributes to susceptibility to bipolar affective disorder in some families.
|
8561212 |
1996 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have earlier reported evidence against linkage between manic depressive illness and tyrosine hydroxylase and dopamine beta-hydroxylase.
|
8750358 |
1995 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have searched for a possible association between polymorphic DNA markers of two candidate genes (tyrosine hydroxylase, TH; dopamine D2 receptor gene, DRD2) and BP in a population from central Spain.
|
7760324 |
1995 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other promising results concern the tyrosine hydroxylase gene in manic depressive illness and the dopamine D2 receptor in alcoholism.
|
7919920 |
1994 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nonlinkage of bipolar illness to tyrosine hydroxylase, tyrosinase, and D2 and D4 dopamine receptor genes on chromosome 11.
|
7903509 |
1994 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Exclusion of linkage between manic depressive illness and tyrosine hydroxylase and dopamine D2 receptor genes.
|
7914141 |
1994 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The candidate genes tyrosine hydroxylase (TH) and the dopamine D4 receptor gene (DRD4) are both located in the 11p15.5 region, thus creating strong interest in this region for genetic studies of bipolar affective disorder.
|
7914460 |
1994 |
|
Bipolar Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus the hypothesis that TH is involved in the pathogenesis of bipolar affective disorder was not supported.
|
8103293 |
1993 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies have attempted to link (bipolar) affective disorder to the short arm of chromosome 11 (where the loci for insulin, insulin growth factor (IGF), tyrosine hydroxylase (TH) and h-ras-oncogene are located) but these have failed.
|
8145651 |
1993 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
As TH mutations could underlie susceptibility to manic-depression, we carried out a linkage analysis between this disease in 8 families and two RFLP probes that map to the TH gene region on the short arm of chromosome 11.
|
1355073 |
1992 |
|
Bipolar Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tyrosine hydroxylase polymorphisms and bipolar affective disorder.
|
1685750 |
1991 |