TH, tyrosine hydroxylase, 7054

N. diseases: 321; N. variants: 71
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.050 AlteredExpression phenotype BEFREE We further assessed AUR effects in vivo, investigating tyrosine hydroxylase (TH) expression in the striatum and substantia nigra of MPTP-induced PD model mice and behavioral changes after injection of AUR. 31336718 2019
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.050 Biomarker phenotype BEFREE As REMS and its loss associated changes in NA modulates several pathophysiological processes, in this review we have attempted to explain on one hand how the epigenetic mechanisms regulating the gene expression of factors like tyrosine hydroxylase (TH), monoamine oxidase (MAO), noradrenaline transporter (NAT) control NA levels and on the other hand, how NA per se may affect other molecules in neural circuitry at epigenetic level resulting in behavioral changes in health and diseases. 26813120 2016
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.050 Biomarker phenotype BEFREE It may be involved in the pathophysiology of psychiatric disorders and positive associations have been reported for TH gene markers in mood disorders. 9613850 1998
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.050 AlteredExpression phenotype BEFREE Lack of TH expression in the cells that normally express the dopaminergic phenotype resulted in a marked reduction of dopamine accumulation in the tissues, which led to multiple behavioral abnormalities at the juvenile stage. 9822156 1998
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.050 GeneticVariation phenotype BEFREE In light of other data the variation of TH-K1 and TH-K3 suggests that these alleles may reflect predisposition for a common phenotype with altered vulnerability for psychiatric disorders. 9335198 1997