TH, tyrosine hydroxylase, 7054

N. diseases: 321; N. variants: 71
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 Biomarker phenotype BEFREE Intranasal Administration of Extracellular Vesicles Derived from Human Teeth Stem Cells Improves Motor Symptoms and Normalizes Tyrosine Hydroxylase Expression in the Substantia Nigra and Striatum of the 6-Hydroxydopamine-Treated Rats. 30706999 2019
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 Biomarker phenotype BEFREE We observed no motor symptoms or changes in striatal [<sup>11</sup> C]DTBZ binding potential in vivo or striatal or SN TH staining in vitro between the groups. 30009467 2018
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 AlteredExpression phenotype BEFREE Immunohistochemical analysis of tyrosine hydroxylase (TH) showed that EA treatment had no effect on TH expression in the ipsilateral striatum or substantia nigra pars compacta, though it alleviated several of the parkinsonian motor symptoms. 29508251 2018
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 Biomarker phenotype BEFREE PD rats were subjected to DBS of the STN (STN-DBS) and the effects on motor symptoms and number of nigral tyrosine hydroxylase-positive (TH<sup>+</sup>) neurons was examined. 29792848 2018
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 Biomarker phenotype BEFREE Furthermore, these results suggest that short-term voluntary exercise is sufficient to alleviate cognition deficits and depressive behavior in 6-OHDA lesioned rats and long-term treatment reduces the progression of motor symptoms and elevates tyrosine hydroxylase (TH), Brain-derived neurotrophic factor (BDNF), bone marrow tyrosine kinase in chromosome X (BMX) protein expression level without affecting dopaminergic (DA) neuron loss in this PD rat model. 29419747 2018
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 Biomarker phenotype BEFREE When we transplanted these cells into the unilateral lesioned SN induced by striatal injection of 6-hydroxydopamine (6-OHDA), a significant hypertrophy of nigral tyrosine hydroxylase (TH)(+) cells, an increase of striatal TH-staining and stabilization of amphetamine-induced motor symptoms were observed. 20542127 2010
CUI: C0426980
Disease: Motor symptoms
Motor symptoms
0.070 AlteredExpression phenotype BEFREE The predominant loss of TH expression in striosomes occurred during the early postnatal period, when motor symptoms first appeared. 18713855 2008