|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Noradrenergic dysfunction due to abnormalities in the tyrosine hydroxylase (TH) gene has been implicated in the pathogenesis of suicidal behavior in mood disorders.
|
24275212 |
2014 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Noradrenergic dysfunction due to abnormalities in the tyrosine hydroxylase (TH) gene has been implicated in the pathogenesis of suicidal behavior in mood disorders.
|
24275212 |
2014 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
Because of its key regulatory role in central and peripheral catecholamine synthesis, TH is associated with the pathogenesis of several neurological and psychiatric diseases, including Parkinson's disease, dystonia, schizophrenia, affective disorders, and cardiovascular diseases.
|
23537934 |
2013 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
It is of great interest that prostaglandin-endoperoxide synthase 2, tyrosine hydroxylase, Cart, Homer1 and glutamate decarboxylase have already been implicated in affective disorders by different approaches in previous reports.
|
18371075 |
2008 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
|
12782971 |
2003 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
|
12782971 |
2003 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
LHGDN |
The study could not support the involvement of tyrosine hydroxylase, catechol-O-methyl transferase and Wolfram syndrome 1 polymorphisms in mood disorders.
|
12782971 |
2003 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients.
|
10760558 |
2000 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
PSYGENET |
The D2 and D3 dopamine receptors were, therefore, not a major liability factor for mood disorders in our sample, whereas TH may play a role in a subgroup of patients.
|
10760558 |
2000 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In each analysis there was no association of the TH tetranucleotide repeat polymorphism and affective disorder.
|
10050974 |
1999 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To find variants in the tyrosine hydroxylase (TH) gene that are associated with schizophrenia, mood disorders, or alcohol dependence, all of the exons, the exon-intron boundaries, and the 5' promoter region of the TH gene were systematically screened for variants by single-strand conformation polymorphism analysis followed by direct nucleotide sequencing.
|
9754624 |
1998 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our results suggest a moderate linkage disequilibrium of TH variants with mood disorders.
|
9577842 |
1998 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our sample includes 46 mood disorder subjects, investigated by the OPCRIT (operational criteria checklist for psychotic illness) checklist for their symptomatological pattern and typed for TH variants by polymerase chain reaction (PCR) amplification.
|
9613850 |
1998 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
No significant differences in allele and genotype frequencies were observed between the two groups, providing further evidence against a major role for the tyrosine hydroxylase gene in the etiology of major affective disorders.
|
8912950 |
1996 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
These results provide some support for linking affective disorder to this genetic region and suggest that additional linkage and association studies should be conducted to determine whether tyrosine hydroxylase or a nearby locus contributes to susceptibility to bipolar affective disorder in some families.
|
8561212 |
1996 |
|
Mood Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
These results indicate that TH gene is less likely to contribute to the genetic component of affective disorders.
|
7665810 |
1995 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We present the results of a linkage analysis using polymorphic DNA segments within the TH gene and the nearby dopamine D4 receptor (DRD4) gene in 6 families multiply affected with affective disorder.
|
7907843 |
1993 |
|
Mood Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Therefore, we tested 88 patients with affective disorders and 99 healthy control persons for association of restriction fragment length polymorphism (RFLP) alleles at the tyrosine hydroxylase locus.
|
1975102 |
1990 |