TH, tyrosine hydroxylase, 7054

N. diseases: 321; N. variants: 71
Disease: Lewy Body Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.330 Biomarker disease CTD_human The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease. 30236862 2019
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.330 Biomarker disease BEFREE We quantified nigrostriatal dopaminergic integrity with image analysis of putaminal tyrosine hydroxylase immunoreactivity in 492 brains with Lewy body disease and used this pathologic endophenotype to explore possible association with PD genetic variants. 28949048 2017
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.330 Biomarker disease LHGDN Reduced striatal tyrosine hydroxylase in incidental Lewy body disease. 17985144 2008
CUI: C0752347
Disease: Lewy Body Disease
Lewy Body Disease 		0.330 AlteredExpression disease BEFREE Because changes in these noradrenergic markers in AD versus DLB subjects were similar (except neuronal loss and the increase in TH mRNA were somewhat greater in DLB subjects), the presence of Lewy bodies in addition to plaques and tangles in DLB subjects does not appear to further affect the noradrenergic compensatory changes. 16407544 2006