Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Similar to that found in hypothyroidism or TRα deficiency during the juvenile period, the B-cell population is reduced in the spleen and bone marrow of ageing TRα1/TRβ-knockout mice, suggesting that TRβ does not play a major role in B-cell development.
|
31585438 |
2020 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Thyroid hormone receptor alpha (THRA) gene mutation is a thyroid hormone resistance syndrome characterized by near-normal thyroid function tests and tissue-specific hypothyroidism.
|
30747412 |
2019 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
A severe phenotype characteristic of hypothyroidism occurs in children with resistance to thyroid hormone due to mutations affecting THRA encoding thyroid hormone receptor α (TRα).
|
28853052 |
2018 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
The present study, therefore, is designed to examine the effect of neonatal hypothyroidism on prepubertal Parkes (P) strain mice testis in relation to thyroid hormone receptor alpha 1 (THRα1).
|
27519547 |
2017 |
Hypothyroidism
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Regarding the modulation of gene expression in the testis, hypothyroidism increased the expression of Thra1 and decreased the expression of Dio3, and hyperthyroidism increased the expression of Slc16a2.
|
27066791 |
2017 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Despite heterogeneous consequences of mutations in THRA, RTHα should be suspected in subjects with even mild clinical features of hypothyroidism together with high/high-normal (F)T3, low/low-normal (F)T4, and normal TSH.
|
28527577 |
2017 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Patients with mutations of the THRA gene exhibit classical features of hypothyroidism, including erythroid disorders.
|
28910278 |
2017 |
Hypothyroidism
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Hypothyroidism due to THRA1 (gene coding for thyroid hormone receptor α1) mutation-mediated Resistance to Thyroid Hormone (RTH) has been recently reported in human and is associated with memory deficits similar to those found in a mouse model for Thra1 mutation mediated RTH (Thra1(+/m) mice).
|
26743578 |
2016 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
On this basis, specific issues of special interest for cardiology are discussed, namely (1) relevance of the regulation of proteins involved in the control of calcium homeostasis and in pacemaker cell activity, due to non-genomic as well as to classical genomic effects; (2) stimulation of fatty acid oxidation by T2 and T1AM, the latter also causing a negative inotropic and chronotropic action at micromolar concentrations; (3) induction of D3 deiodinase in heart failure, potentially causing selective cardiac hypothyroidism, whose clinical implications are still controversial; and (4) cardioprotective effect of T1AM, possibly occurring at physiological concentrations, and relevance of T3 and of thyroid hormone receptor α1 in post-infarction repair.
|
27115768 |
2016 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
In patients with clinical symptoms of mild hypothyreosis without confirmation in endocrine studies, a molecular study of THRA defects is strongly recommended.
|
25670821 |
2015 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
BEFREE |
Thyroid hormone receptor alpha plays an essential role in the normalisation of adult-onset hypothyroidism-related hypoexpression of synaptic plasticity target genes in striatum.
|
19094093 |
2009 |
Hypothyroidism
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|