Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, understanding the molecular mechanisms that contribute to CNV as a consequence of TIMP-3 mutations will provide insight into the pathophysiology in SFD and likely the neovascular component of the more commonly seen AMD.
|
31757977 |
2019 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
TIMP-3 suppression induces choroidal neovascularization by moderating the polarization of macrophages in age-related macular degeneration.
|
30594674 |
2019 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results provide new insights into the pathogenesis of SFD and other retinopathies linked to mutations in TIMP3, such as age-related macular degeneration.
|
30668888 |
2019 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Understanding the molecular functions of wild-type and mutant TIMP3 will provide significant insights into the patho-physiology of SFD and perhaps AMD.
|
30129971 |
2019 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found that patients with neovascular AMD had lower plasma concentration of TIMP-3 (p = 0.028) than healthy controls.
|
30288950 |
2019 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Interestingly, we observed increased expression of tissue inhibitor of metalloproteinase 3 (Timp3) during the aging process, a gene associated with AMD and Bruch's membrane integrity.
|
29514656 |
2018 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found that the expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with AMD pathology in both groups (LIPC: P = 0.008, SLC16A8: P < 0.001, TIMP-3: P < 0.001, respectively).
|
27966779 |
2017 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
CTD_human |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A rare penetrant TIMP3 mutation confers relatively late onset choroidal neovascularisation which can mimic age-related macular degeneration.
|
26493035 |
2016 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A recent genome-wide association studies (GWAS) reported that rs9621532 near the tissue inhibitor of metalloproteinase 3 (TIMP3)/synapsin III (SYN3) region of 22q12.3 is associated with AMD.
|
23422939 |
2013 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, two genome-wide association studies with large cohorts both identified rs9621532, a new single nucleotide polymorphism (SNP) that is associated with advanced age-related macular degeneration (AMD) and located near the TIMP3 gene.
|
22171703 |
2012 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
With the sample size of our study, no relationship was found for AMD and the SNPs tested in complement 3 (C3); serpin peptidase inhibitor, clade G, member 1 (SERPING1); vascular endothelial growth factor (VEGF); cholesterol ester transfer protein (CETP); lipoprotein lipase (LPL); hepatic lipase (LIPC); and metallopeptidase inhibitor 3 (TIMP3) genes.
|
22618592 |
2012 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results confirm associations of AMD with variants near the TIMP3 gene and at loci involved in HDL metabolism.
|
21613373 |
2011 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.
|
20385819 |
2010 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
LHGDN |
We also discuss briefly how, despite the lack of inherited mutations in the structural gene, the TIMP3 protein might play a role in the onset and progression of AMD.
|
16259644 |
2005 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
We also discuss briefly how, despite the lack of inherited mutations in the structural gene, the TIMP3 protein might play a role in the onset and progression of AMD.
|
16259644 |
2005 |
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Our results were supported by significant accumulation and expression overlap of both TIMP-3 and EFEMP1 between the retinal pigment epithelia and Bruch membrane in the eyes of ML and AMD patients.
|
15123717 |
2004 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Increased expression of TIMP-3 mRNA does not cause accumulation of TIMP-3 in the Bruch membrane of Sorsby fundus dystrophy nor is it likely to cause age-related macular degeneration.
|
14597066 |
2003 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The previously unreported finding of TIMP-3 induced apoptosis of RPE cells may account for some of the early features seen in SFD and ARMD.
|
11801512 |
2002 |
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of TIMP-3 is also observed in other degenerative retinal diseases, including the more severe forms of age-related macular degeneration, the most common cause of blindness in the elderly in developed countries.
|
10854443 |
2000 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to determine whether TIMP3 is a major susceptibility gene for the AMD phenotype.
|
9152225 |
1997 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The authors' results suggest that TIMP3 is not a major factor in the cause of AMD, AVMD, and CACD.
|
9152224 |
1997 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|