Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Histology identified a diffuse sclerosing variant of papillary thyroid carcinoma that was positive for TTF-1 and napsin A but negative for PAX8.
|
31653481 |
2019 |
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
It morphologically resembles papillary thyroid carcinoma and is immunochemically positive for thyroid transcription factor 1.
|
29494399 |
2019 |
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Loss of nuclear localization of thyroid transcription factor 1 and adverse outcomes in papillary thyroid cancer.
|
31229486 |
2019 |
Papillary thyroid carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Histopathologically, TL-LGNPPA is characterized by cuboidal/columnar tumor cells forming papillary fronds and thyroid transcription factor-1 (TTF-1) expression resembling papillary thyroid carcinoma.
|
28601658 |
2017 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to analyse the association of PTC risk with SNPs in FOXE1 (rs965513, rs1867277, rs1443434) and near the NKX2-1 locus (rs944289) in a Polish population, and, in the second step, the interac-tion between SNPs and patient-related factors (age at diagnosis and gender).
|
28660995 |
2017 |
Papillary thyroid carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Primary thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare malignant nasopharyngeal tumor with features resembling papillary thyroid carcinoma including nuclear positive expression of thyroid transcription factor-1 (TTF-1).
|
29381996 |
2017 |
Papillary thyroid carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We reveal that platelet derived growth factor receptor alpha (PDGFRα) specifically drives dedifferentiation in PTC by disrupting the transcriptional activity of thyroid transcription factor-1 (TTF1).
|
27682510 |
2016 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A germline mutation (A339V) in thyroid transcription factor-1 (TITF1/NKX2.1) was shown to be associated with multinodular goiter (MNG) and papillary thyroid carcinoma (PTC) pathogenesis.
|
25981745 |
2015 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Results of meta-analysis from the previous study and our new data indicated that variants of rs944289 and rs965513 might be the genetic susceptible factors both in Asians and Caucasians.We get the conclusion that mutations of TTF1 and TTF2 are significantly associated with an increasing risk of PTC in Chinese.
|
26356687 |
2015 |
Papillary thyroid carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPPA) is an extremely rare neoplasm characterized by morphological analogy to papillary thyroid carcinoma and abnormal expression of thyroid transcription factor-1 (TTF-1).
|
24893893 |
2014 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PTC was identified in Europeans by conducting a genome-wide association study, and a strong association signal with PTC was observed in rs944289 and NKX2-1 (located at the 14q13.3 locus), which was probably the genetic risk factor of PTC.
|
24452548 |
2014 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A variant located on 14q13.3 nearest to thyroid transcription factor-1 (TTF1) predisposes individuals to thyroid cancer, but whether this variant is related to the RET/PTC rearrangement associated with human papillary thyroid carcinomas (PTCs) is unknown.
|
24014739 |
2013 |
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thyroglobulin and TTF-1 are the only useful markers in the differential diagnosis between CAMSG and papillary thyroid carcinoma as both tumors may express galectin-3, CK19, and HBME-1.
|
23052371 |
2012 |
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The localization of TCF-4 and TTF-1 in the same area of PTC tissues might be of clinical relevance, and justifies further examination of these factors in the papillary thyroid cancers follow-up.
|
21814573 |
2011 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Both FOXE1 and NKX2-1 were associated with the increased risk of sporadic Japanese PTC.
|
21730105 |
2011 |
Papillary thyroid carcinoma
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Both FOXE1 and NKX2-1 were associated with the increased risk of sporadic Japanese PTC.
|
21730105 |
2011 |
Papillary thyroid carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We evaluated the expression of TTF-1 in primary thyroid tissues (normal thyroid, papillary carcinoma and undifferentiated carcinoma) and in thyroid carcinoma cell lines using immunohistochemistry and RT-PCR.
|
19506552 |
2009 |
Papillary thyroid carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Because thyroid transcription factor-1 (TTF-1) is important to thyroid development, we evaluated whether the gene that encodes it, TITF-1/NKX2.1, is a genetic determinant of MNG/PTC predisposition.
|
19176457 |
2009 |
Papillary thyroid carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Unexpectedly, TTF-1 expression was observed in almost all of the PTC and PDC cases and in half of the UDC cases; therefore, it was not useful to distinguish PDC from PTC or UDC.
|
18497944 |
2008 |
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using a chimeric construct containing the 5'-flanking region of the rat TG gene between -826 and +39 bp and the luciferase gene, TG promoter activity was detected in a normal rat thyroid cell line (FRTL-5), but not in a dedifferentiated line of thyroid cells (FRT) expressing Pax-8 but not TTF-1, TTF-2, or TG [TTF-1(-)/TTF-2(-)/Pax-8(+)/TG(-)], or in a human papillary thyroid carcinoma cell line [BHP15-3; TTF-1(-)/TTF-2(-)/Pax-8(-)/TG(-)], a human pulmonary cell line [H441; TTF-1(+)/TTF-2(-)/Pax-8(-)/TG(-)], or a dog kidney epithelial cell line [MDCK; TTF-1(-)/TTF-2(-)/Pax-8(+)/TG(-)].
|
11325833 |
2001 |
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Papillary thyroid carcinoma
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|