Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR2 genetic polymorphisms influence susceptibility to pulmonary TB.
|
20113509 |
2010 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether the functional genetic variations at position 1805 G/T in TLR1, 2258 A/G in TLR2, -857 C/T, and -863 A/C in tumor necrosis factor-α (TNF-α), as well as -819 C/T in interleukin-10 (IL-10) confer susceptibility to pulmonary tuberculosis (PTB).
|
20650298 |
2010 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we investigated whether variants in the TLR-1 1805T/G (Ile602Ser), TLR-2 2258G/A (Arg753Gln), TLR-4 896A/G (Asp299Gly), TLR-4 1196C/T (Thr399Ile), TLR-6 745C/T (Ser249Pro), TIRAP 975C/T (Ser180Leu) genes and TLR-9 promoter region polymorphisms at positions -1237C/T and -1486C/T are associated with susceptibility or resistance to pulmonary tuberculosis (PTB).
|
20797905 |
2010 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite polymorphisms in intron 2 of the toll-like receptor 2 gene and their association with susceptibility to pulmonary tuberculosis in Han Chinese.
|
20298136 |
2010 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR2 2258G allele and 2258GG genotype were found to be associated with decreased PTB susceptibility (A vs. G: OR = 3.02, 95% CI: 2.22-4.12, P<0.001, GA+AA vs. GG: OR = 2.69, 95% CI = 1.49-4.87, P = 0.001).
|
24124467 |
2013 |
Tuberculosis, Pulmonary
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This study aimed to determine if TLR2 promoter DNA methylation is associated with pulmonary TB.
|
25218055 |
2014 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Role of Toll-like receptor 2 (-196 to -174) polymorphism in susceptibility to pulmonary tuberculosis in Pakistani population.
|
23998736 |
2014 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR2 and TLR4 interaction and a specific VDR haplotype influence protection against PTB in Moroccans patients.
|
24727508 |
2014 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that 597T/C polymorphism, but not Arg677Trp polymorphism, of the TLR-2 gene is a risk factor for susceptibility to PTB in a sample of Iranian population.
|
23830055 |
2014 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TLR2 variant genotype 597CC was associated with susceptibility to PTB rather than to TBM.
|
26722451 |
2015 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In TLR2, the frequencies of the CC genotype (OR = 2.262; 95% CI: 1.433-3.570) and C allele (OR = 1.566; 95% CI: 1.223-1.900) in single-nucleotide polymorphism (SNP) rs3804100 were significantly higher in the LTBI group than in the HC group, whereas the GA genotype of SNP rs5743708 was associated with PTB (OR = 6.087; 95% CI: 1.687-21.968).
|
25928077 |
2015 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since human genetic variation is an important determinant in the outcome of infection with M. tuberculosis, we typed polymorphisms in the innate immune molecules, such as natural-resistance-associated macrophage protein 1 (NRAMP1), Vitamin D receptor (VDR), Tumor necrosis factor alpha (TNF-α), intercellular adhesion molecule1 (ICAM-1), Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) in a case-control study of pulmonary tuberculosis in Iranian population.
|
26774366 |
2016 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Vitamin D levels and genetic factors, vitamin D receptor (VDR) and Toll like receptor- 2 (TLR-2) gene single nucleotide polymorphisms (SNPs), determine susceptibility to pulmonary tuberculosis.
|
27207494 |
2016 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a significant association between the GA genotype (heterozygous mutant) of TLR2 Arg753Gln polymorphism and the risk of infection with pulmonary TB (p = 0.003, OR = 4.83) and TB peritonitis (p = 0.003, OR = 6.2).
|
28332241 |
2017 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, this study has revealed that person carrying deletion allele in their TLR2Δ22 (-196-174) gene is significantly associated with an increased risk of PTB having b/b or F/f genotypes in BsmI or FokI polymorphisms of VDR gene.
|
29727015 |
2018 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant association between polymorphisms of TLR2 and TLR4 with PTB or LTBI was detected.
|
29924447 |
2018 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genotyping was performed to detect -196 to -174 del polymorphism and G2258A SNP (Arg753Gln, rs5743708) in TLR2 gene and -T1237C (rs5743836) and G2848A (rs352140) SNP in TLR9 gene in patients with pulmonary TB and healthy controls.
|
29675696 |
2018 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
(3) Stratified by sample type, TLR2 Arg753Gln polymorphism is associated with increased PTB risk, but not with EPTB.
|
30733958 |
2019 |
Tuberculosis, Pulmonary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms rs3804099 (TLR2) and rs352139 (TLR9) may also be associated with PTB risk in the Moldavian population but their effect is less consistent across different studies.
|
30529560 |
2019 |
Tuberculosis, Pulmonary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that differences exist in the expression of a surface protein (Toll-like receptor 2) between macrophages recovered from the sputum of individuals in different diagnostic groups: i.e., infection free, latent tuberculosis infection, and active pulmonary tuberculosis.
|
29104936 |
2019 |