Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Tolerance induced by the TLR2 agonist bacterial lipoprotein (BLP) has been shown to attenuate the inflammatory response, and simultaneously to augment antimicrobial function, thereby conferring its protection against microbial sepsis.
|
31152389 |
2020 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 2 (TLR2) is currently investigated as a potential therapeutic target in diseases with underlying inflammation like sepsis and arthritis.
|
30509503 |
2019 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We also demonstrated blockade of intracellular signaling from TLR4 and TLR2 by thiol-modifying compounds which suggest a novel therapeutic intervention for sepsis, hyperoxia-induced cell injury and yeast infection.
|
31843260 |
2019 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, the response to a TLR2 ligand is muted in cohoused mice, whereas the response to a TLR4 ligand is greatly amplified, suggesting a basis for the distinct response to Listeria monocytogenes and sepsis.
|
31412243 |
2019 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Overall, our study provides a suggestion that TLRs 2, 3, 4 and 7 are highly expressed in the kidneys of septic mice and especially that these TLRs are sensitive and specific markers for sepsis.
|
30850654 |
2019 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Circadian Rhythms Influence the Severity of Sepsis in Mice via a TLR2-Dependent, Leukocyte-Intrinsic Mechanism.
|
29760192 |
2018 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We observed a decrease of TLR2 and 9 mRNA expression in the liver of the sepsis group, while TLR3 was decreased in the lung and liver.
|
28391364 |
2017 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
However, early-onset sepsis in term babies is caused by gram-positive species in more than 90% of cases, and neuro-inflammatory responses triggered through the gram-negative route (Toll-like receptor 4, TLR-4) are different from those induced through the gram-positive route via TLR-2.
|
28407632 |
2017 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD19<sup>+</sup>CD11b<sup>+</sup>CD5<sup>+</sup> B1a regulatory cells were shown to rapidly express IL-10 in a TLR2-dependent manner in response to <i>S. aureus</i>, and adoptive transfer of B1a cells was protective during acute systemic infection in IL-10-deficient hosts.
|
28167629 |
2017 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
TLR-2 and TLR-4 expression in monocytes of newborns with late-onset sepsis.
|
24878008 |
2015 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In addition, subgroup analyses based on age group, ethnicity, sepsis type, and source of control also showed a significant effect of the TLR2 Arg753Gln polymorphism on sepsis risk.
|
26616674 |
2015 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the associations between expression of TLR2, TLR4 and TLR9 and occurrence of sepsis in patients treated with intensive induction chemotherapy for AML.
|
25412934 |
2014 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the toll-like receptor 2 and 4 genes are associated with faster progression and a more severe course of sepsis in critically ill patients.
|
24366499 |
2014 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We find that although TLR2 may recognize virus preparations in vitro and have a minor role in preventing dissemination of VACV following systemic infection with large doses of virus, it is wholly disposable in both control of virus replication and induction of adaptive immunity following intradermal infection.
|
24403581 |
2014 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptors, especially TLRs 2 and 4, are associated with necrotizing enterocolitis, periventricular leukomalacia and sepsis.
|
23419040 |
2013 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study suggests that endothelial TLR2 may be an important regulator of neutrophil trafficking to sites of infection in general, and that direct activation of lung endothelial TLR2 may contribute to acute lung injury during sepsis.
|
22186927 |
2012 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Here we found that phagocytes from patients with sepsis had considerable upregulation of Toll-like receptor 4 (TLR4) and TLR2; however, shock-inducing inflammatory responses mediated by these TLRs were inhibited by ES-62, an immunomodulator secreted by the filarial nematode Acanthocheilonema viteae.
|
21358639 |
2011 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We investigated the supposed-2029C>T and 2258G>A TLR2 polymorphisms in 422 critically ill patients of European origin from southern Brazil (295 with sepsis and 127 without sepsis) and reviewed 33 studies on these polymorphisms, conducting a quality assessment with a score system.
|
20578945 |
2010 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
HES could ameliorate BBB dysfunction and inflammation mediators by modulating brain TLR2 and TLR4 expression during sepsis.
|
20451670 |
2010 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in TLR2 (rs3804099), TLR5 (rs5744105), IL10 (rs1800896), and PLA2G2A (rs1891320) genes were associated with sepsis.
|
20463618 |
2010 |
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, our data suggest that the IL10-819 and TLR-2 polymorphisms may be potential predictors of sepsis.
|
20835611 |
2010 |
Sepsis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Previous study from our laboratory has demonstrated that in a setting of sepsis, toll-like receptor-4 (TLR4) signaling can induce TLR2 expression in endothelial cells (ECs), thereby increasing the cells' response to TLR2 ligands.
|
19828841 |
2009 |
Sepsis
|
0.300 |
Biomarker
|
disease |
RGD |
[Effects of antimicrobial agents on the Toll like receptors and myeloid differentiation protein-2 in liver tissue of alcohol-induced liver disease: experiment with rats].
|
19489280 |
2009 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
To validate the concept of TLR4-targeted treatment strategies in gram-negative sepsis, we first showed that TLR4(-/-) and myeloid differentiation primary response gene 88 (MyD88)(-/-) mice were fully resistant to Escherichia coli-induced septic shock, whereas TLR2(-/-) and wild-type mice rapidly died of fulminant sepsis.
|
19181857 |
2009 |
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In conclusion, mature BLPs, and not LTA, are the major TLR2 activating factors from GBS and significantly contribute to GBS sepsis.
|
18424736 |
2008 |