|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
CTD_human |
Inhibitory effects of kaempferol-3-O-sophoroside on HMGB1-mediated proinflammatory responses.
|
22178603 |
2012 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
LHGDN |
C-Jun NH2 terminal kinase (JNK) is an essential mediator of Toll-like receptor 2-induced corneal inflammation.
|
18218857 |
2008 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
LHGDN |
These results suggest that TLR2 and TLR4 may play a role in aortic valve inflammation and stenosis.
|
17942642 |
2008 |
|
Inflammation
|
0.560 |
AlteredExpression
|
phenotype |
LHGDN |
Taking together, these studies reveal coordinated induction of TLR2 and TLR6 during hypoxia and suggest tissue hypoxia in transcriptional adaptation of innate immune responses during acute infection or inflammation.
|
18159247 |
2007 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
LHGDN |
These observations support the notion of a potential role for activation through TLR-2 and TLR-4 in the inflammation and joint destruction of RA.
|
17599732 |
2007 |
|
Inflammation
|
0.560 |
Biomarker
|
phenotype |
RGD |
We could thus demonstrate that activation of TLR-2 and -6 can induce systemic inflammation in rats accompanied by the classical signs of brain-controlled illness responses.
|
16154916 |
2006 |
|
Inflammation
|
0.560 |
AlteredExpression
|
phenotype |
LHGDN |
Expression of Toll-like receptor 2 is up-regulated in monocytes from patients with chronic obstructive pulmonary disease.
|
16606450 |
2006 |
|
Inflammation
|
0.560 |
AlteredExpression
|
phenotype |
LHGDN |
Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis.
|
16146574 |
2005 |
|
Keratitis
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Exogenous TSLP with Aspergillus led to severe keratitis and worse corneal recovery with higher levels of TLR2, TLR4, IL-6, and IL-8 as well as increased neutrophil infiltration.
|
30853520 |
2019 |
|
Keratitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
Our findings reveal a critical role for the PRRs TLR2 and 9, and their adaptor protein MyD88, in corneal inflammation upon adenovirus infection.
|
27528076 |
2017 |
|
Keratitis
|
0.550 |
Biomarker
|
disease |
CTD_human |
Resveratrol role in Staphylococcus aureus-induced corneal inflammation.
|
23661603 |
2013 |
|
Keratitis
|
0.550 |
Therapeutic
|
disease |
RGD |
This study aims to investigate the effect of targeting TLR2 on Aspergillus fumigatus keratitis in rats.
|
21647173 |
2012 |
|
Keratitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
Toll-like receptor 2 (TLR2) is an essential mediator of corneal inflammation induced by the filarial nematode Onchocerca volvulus, which harbors endosymbiotic Wolbachia bacteria.
|
19168746 |
2009 |
|
Keratitis
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
The Western blot showed the protein expression of TLR2, 4, and 9 was also upregulated in the corneas with F. solani keratitis than that of the healthy corneas.
|
18398706 |
2008 |
|
Keratitis
|
0.550 |
Biomarker
|
disease |
BEFREE |
These findings indicate that S. aureus-induced corneal inflammation is mediated by TLR2 and MyD88 in resident epithelial cells and infiltrating neutrophils.
|
16926427 |
2006 |
|
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
CTD_human |
Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways.
|
25780291 |
2015 |
|
Reperfusion Injury
|
0.500 |
Biomarker
|
disease |
RGD |
Ischemia-reperfusion injury activates innate immunity in rat kidneys.
|
15912106 |
2005 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
It was positively associated with TLR2 and TLR4 in RA.
|
31620132 |
2019 |
|
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum TLR2 and TLR4 levels in colorectal cancer and their association with systemic inflammatory markers, tumor characteristics, and disease outcome.
|
31132191 |
2019 |
|
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found associations between polymorphisms in TLR2 (P = 0.018) and TLR4 (P = 0.044) and risk of CRC per se, interactions between intake of red and processed meat (10 g/d) and polymorphisms in TLR1 (P-interaction = 0.032) and TLR10 (P-interaction = 0.026 and 0.036), and intake of cereals (50 g/d) and TLR4 (P-interaction = 0.044) in relation to risk of CRC.
|
29566186 |
2018 |
|
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate TLR2 (-196 to-174del), TLR4 (Asp299Gly and Thr399Ile) and TLR9 (T1237C and T1486C) gene polymorphisms at risk of colorectal cancer (CRC) development and progression.
|
29883450 |
2018 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, as in the case of other animal intestinal diseases, the protective role of PSA against CRC pathogenesis was also mediated by TLR2.Our results reveal that PSA from <i>B. fragilis</i> plays a protective role against CRC via TLR2 signaling.
|
30065713 |
2018 |
|
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these findings demonstrate that TLR2 plays an important role in colorectal tumorigenesis and may represent a promising therapeutic target in CRC.
|
29689497 |
2018 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effect of TLR2-activation on mitochondrial function and bioenergetics in primary RA-synovial fibroblast cells (RASFC), and further determined the role of glycolytic blockade on TLR2-induced inflammation in RASFC using glycolytic inhibitor 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO).
|
28225071 |
2017 |
|
Rheumatoid Arthritis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importantly, M2 macrophages derived from HD or patients with RA showed both a decreased ratio of interleukin (IL)-10/IL-6 and IL-10/IL-8 upon stimulation with TLR2 ligand Pam3 compared with TLR4 ligand LPS.
|
29096690 |
2017 |