TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE The results of this meta-analysis suggest that the rs4986790 and rs4986791 polymorphisms in toll like receptor 4 gene may have no statistically significant influence on sepsis susceptibility. 27958344 2016
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Candidate single nucleotide polymorphisms (SNPs) within bacterial recognition (TLR4 +896, CD14 -159) and inflammatory response (TNF-alpha -308, IL-1beta -31, IL-6 -174) loci were evaluated for association with increased risk for severe sepsis (sepsis plus organ dysfunction or septic shock) and mortality. 15520404 2004
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Consequently, this study was not able to detect associations between TLR4 polymorphisms and sepsis in this population. 23871732 2013
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Adjusting for independent risk factors, carriage of the variant TLR4 896 G allele was associated with decreased risk of complicated sepsis (odds ratio = 0.3, 95% confidence interval, 0.1-0.7, p = 0.008). 19131814 2009
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE The toll-like receptor 4/2242 polymorphism is a functional variant and might be used as a relevant risk estimate for organ dysfunction and sepsis in trauma patients. 20228685 2010
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Candidate genes for asthma and allergic diseases co-associated with sepsis including innate immunity receptors and related molecules (CD14, TLR4 and AOAH) and novel genes such as MYLK provide good examples of pleitropic effects of innate immunity genes, where variants conferring risk to specific traits (i.e. sepsis) under one set of genetic and environmental circumstances confer a reduced risk in a different (but possibly related) clinical outcome (i.e. allergic asthma), and support the 'common variant/multiple disease' hypothesis. 17989521 2007
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Our study investigated the association between TLR4 mutations (Asp299Gly and Thr399Ile) and CD14 polymorphism(s) with outcome in an intensive care unit (ICU) population at risk for sepsis. 12404174 2002
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Influence of genetic variations in TLR4 and TIRAP/Mal on the course of sepsis and pneumonia and cytokine release: an observational study in three cohorts. 20525286 2010
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections. 20375592 2009
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Two commonly occurring SNPs in the human TLR4 gene (Asp299Gly and Thr399Ile) have been shown to be associated with increased risk of Gram-negative bacteremia in sepsis patients and with susceptibility to inflammatory bowel disease. 18034244 2008
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Serum levels of tumour necrosis factor, interleukin (IL)-10, and IL-6 at sepsis onset did not significantly differ between patients carrying wild-type and mutant TLR4. 12807489 2003
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE In conclusion, differences in distribution of TLR4 polymorphisms Asp299Gly and Thr399Ile in European populations are most likely due to a combination of population migration events combined with selection due to sepsis. 21968286 2012
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE To simulate sepsis, male C57BL/6 (wild-type) and C57BL/10ScNJNJU (TLR4<sup>-/-</sup>) mice were subjected to cecal ligation and puncture (CLP). 29149705 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Specific point mutations in the human toll-like receptor 4 (TLR4) confer altered risk for diverse diseases including sepsis, aspergillosis and inflammatory bowel disease. 30885307 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Combined with our previous in vitro functional study, the results suggest that the TLR4 11367 polymorphism might be a good predictor of who is more likely to develop complications such as sepsis or multiple organ dysfunction syndrome, depending on genotype. 20026833 2009
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively). 25427560 2015
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE This study aimed to investigate whether organ failure in sepsis patients is related to the TLR4 rs11536889 genotype. 24950711 2014
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Interestingly, TLR4-D299G, TLR4-T399I and BAFFR-P21R carriage was associated with a lower risk of ICU-acquired sepsis. 25454804 2015
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Some, but not all, epidemiological studies have suggested that Toll-like receptor 4 (TLR4) polymorphisms, Asp299Gly and Thr399Ile, may influence the risk of at-risk patients for sepsis. 22537674 2012
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE The rs11536889 polymorphism in TLR4 and rs2563298 polymorphism in CD14 were significantly associated with the risk of sepsis when compared to the control group. 25394369 2014
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.600 GeneticVariation disease BEFREE Genetic polymorphisms of CD14, toll-like receptor 4, and caspase-recruitment domain 15 are not associated with necrotizing enterocolitis in very low birth weight infants. 16385250 2006
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 GeneticVariation group LHGDN Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduced prevalence of diabetic neuropathy in type 2, but not in type 1, diabetes. 14693986 2004
CUI: C0011882
Disease: Diabetic Neuropathies
Diabetic Neuropathies
0.510 GeneticVariation group BEFREE Our data indicate that Asp299Gly and Thr399Ile genotypes of the TLR4 gene are associated with reduced prevalence of diabetic neuropathy in type 2, but not in type 1, diabetes. 14693986 2004
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.500 GeneticVariation disease BEFREE Polymorphisms in CARD15 and TLR4 have been linked with Crohn's disease (CD). 17504508 2007
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.500 GeneticVariation disease BEFREE Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism. 29055077 2017