TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Exercise Training Attenuates Hypertension Through TLR4/MyD88/NF-κB Signaling in the Hypothalamic Paraventricular Nucleus. 31708733 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE <b>NEW & NOTEWORTHY</b> Angiotensin II (ANG II)-induced hypertension is dependent on the endosomal Toll-like receptor 3 (TLR3)-Toll-interleukin receptor domain-containing adaptor protein-inducing interferon-β (TRIF) pathway of the innate immune system but not on cell membrane localized TLR4. 30793936 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 GeneticVariation group BEFREE Blockade of c-Src Within the Paraventricular Nucleus Attenuates Inflammatory Cytokines and Oxidative Stress in the Mechanism of the TLR4 Signal Pathway in Salt-Induced Hypertension. 31641986 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Toll-like receptor 4 (TLR4) activation contributes to vascular dysfunction in pathological conditions such as hypertension and diabetes, but the role of chronic TLR4 activation on renal autoregulatory behavior is unknown. 31432707 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE In this review, we discuss the emerging role of TLR4 in the pathogenesis of hypertension and whether targeting this receptor and its signalling pathways could offer a therapeutic strategy for management of this multifaceted disease. 29981161 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Intermedin in Paraventricular Nucleus Attenuates Sympathoexcitation and Decreases TLR4-Mediated Sympathetic Activation via Adrenomedullin Receptors in Rats with Obesity-Related Hypertension. 30276527 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE HMGB1/TLR4 promotes hypoxic pulmonary hypertension via suppressing BMPR2 signaling. 30610955 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Toll-like receptor 4 (TLR4) has been implicated in the progression of cardiovascular disease, including hypertension. 29767672 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Effects of small interfering RNA targeting TLR4 on expressions of adipocytokines in obstructive sleep apnea hyponea syndrome with hypertension in a rat model. 29215742 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 GeneticVariation group BEFREE We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia. 30211669 2018
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE One of the possible receptors that could have significant attention in the field of hypertension is toll-like receptor 4 (TLR-4). 28386844 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE The interplay between Angiotensin II, TLR4 and hypertension. 28330785 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Recent studies implicate TLR4 activation and oxidative stress in cardiovascular diseases and also as a link between inflammation and hypertension. 28743964 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE Toll-like receptor 4 (TRL4) is a molecule involved in the immune response pathway and is quickly becoming a receptor of interest in the field of hypertension. 28738166 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE The objective of this study was to define the mechanisms of homocysteine-induced effects on the aortic wall that promote vascular remodeling and hypertension as well as explore the role of Toll-like receptor 4 in homocysteine-induced effects. 28665886 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 AlteredExpression group BEFREE ρ=0.566, P<0.001) whereas in well-controlled patients a correlation was found between hypertension duration and TLR4 expression (ρ=0.322, P=0.020). 28359064 2017
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group CTD_human Our findings suggest that TLR4/MyD88/NF-κB signaling and PPAR-γ within the PVN are involved in the beneficial effects of telmisartan in hypertension. 27292124 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE In the present study, we showed that resistin induces hypertension and IR in wild type (WT) mice, but not in tlr4(-/-) mice. 26917360 2016
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 AlteredExpression group BEFREE Animal study proved that HMGB1 contributed to the pathogenesis of experimental pulmonary hypertension (HT) via activation of TLR4. 25050807 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker group BEFREE TLR4 D299 G showed an inverse association with pulmonary hypertension. 25182168 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 GeneticVariation group BEFREE Genetic deletion of toll-like receptor 4 on platelets attenuates experimental pulmonary hypertension. 24637196 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 AlteredExpression group BEFREE High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of Toll-like receptor 4. 23269975 2013
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 GeneticVariation group BEFREE The frequency of SNP896A/G in the TLR4 gene was not associated with AMI and arterial hypertension. 22229967 2012
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 GeneticVariation group BEFREE After adjustment for maternal age and chronic hypertension, attenuating allelic variants of TLR4 were more common in women with a history of early-onset preeclampsia than in controls (OR 2.9 [95% CI 1.2-6.7]). 18382655 2008