|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Multiple lines of evidence suggest that the excessive activation of Toll-like receptor 4 (TLR4) plays an important role in this detrimental lung inflammation.
|
30597258 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, XIST may be involved in progression of cell inflammatory response, and XIST/miR-370-3p/TLR4 axis thus may shed light on the development of novel therapeutics to the treatment of acute stage of pneumonia.
|
31066476 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
PA LPS is recognized by Toll-like receptors-4 (TLR4) and has been shown to induce lung inflammation in vivo.
|
29547450 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results demonstrated that forsythoside B protects against LPS-induced ALI by attenuating inflammatory cell infiltration and suppressing TLR4/NF-κB-mediated lung inflammation.
|
30521962 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Schaftoside, a natural flavonoid compound and a promising treatment for inflammation, has demonstrated potency against LPS-induced lung inflammation in mice; however, its action on TLR4-induced neuroinflammation and mitochondrial dynamics in microglia is still unknown.
|
30528467 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with wild-type (WT) mice, CS-induced pulmonary inflammation was unaltered in TLR2-deficient ( Tlr2<sup>-/-</sup>) and TLR4-deficient ( Tlr4<sup>-/-</sup>) mice.
|
29025711 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice.
|
29869715 |
2018 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The current study examined the roles of the toll like receptor 4 (TLR4) and protease activated receptor 1 (PAR1) pathways on mesenchymal stromal cell (MSC) survival and therapeutic activity in a murine model of pneumonia.
|
29396891 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Toll-Like Receptor 4 (TLR-4) Pathway Promotes Pulmonary Inflammation in Chronic Intermittent Hypoxia-Induced Obstructive Sleep Apnea.
|
30293084 |
2018 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that cigarette smoke adversely affects cholesterol transport via an ABCA1-dependent mechanism in macrophages, enhancing TLR4/myeloid differentiation primary response gene 88 (Myd88) signaling and resulting in matrix metalloproteinase (MMP) up-regulation and exacerbation of pulmonary inflammation.
|
29906247 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that GOH treatment alleviates LPS-induced ALI via inhibiting pulmonary inflammation and apoptosis, a finding that might be associated with the inhibition of TLR4-mediated NF-κB and Bcl-2/Bax signalling pathways.
|
29050341 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Growing sets of data from in vitro and in vivo models demonstrate the role of the innate immune system, especially Toll-like receptor 4 (TLR4) and TLR9, in lung inflammation induced following exposure to contaminants in agricultural environments.
|
28168324 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway.
|
27807045 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ventilated rats pre‑treated with anti‑TLR4 mAb exhibited markedly attenuated signs of ventilation‑induced injury, such as less lung inflammation and pulmonary edema, fewer cells in BALF, and lower levels of ILs and TNF‑α in BALF and plasma.
|
28204830 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway.
|
26882889 |
2016 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, TLR- 4 from the transplanted MSCs plays a seminal role in attenuating in vivo E. coli- induced pneumonia and the ensuing acute lung injury through both its anti- inflammatory and antibacterial effects.
|
26350435 |
2016 |
|
Pneumonia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TLR4 A299G polymorphism was significantly associated with pneumonia risk (OR=1.74; 95% CI 1.19-2.53; P=0.004).The result was significant in adults.
|
25720378 |
2015 |
|
Pneumonia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the cosegregating TLR4 polymorphisms Asp299Gly and Thr399Ile were independent risk factors for the development of both sepsis and pneumonia (OR: 3.55; 95% CI: 1.21-10.4, P=0.021 and OR: 3.57, 95% CI: 1.3-9.86, P=0.014, respectively).
|
25427560 |
2015 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation.
|
25576596 |
2015 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TLR4-mediated pulmonary inflammation may contribute to development of ALI during OLT.
|
26491225 |
2015 |
|
Pneumonia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in toll-like receptor 4 in Mexican-Mestizo patients with intra-abdominal infection and/or pneumonia.
|
23871732 |
2013 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.
|
23475791 |
2013 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, caveolin-1 Y14 phosphorylation was required for the interaction with TLR4 and activation of TLR4-MyD88 signaling and sepsis-induced lung inflammation.
|
24244013 |
2013 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The innate immunity gene, toll-like receptor 4 (TLR4), protects against chronic pulmonary inflammation and tumorigenesis in mice, but the mechanism is unclear.
|
19925653 |
2009 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The roles of Toll-like receptor (TLR) 2 and TLR4, well known NTHi recognizing receptor in lung epithelial cell and gram-negative bacteria receptor, respectively, on the NTHi-induced COX-2 expression were investigated in the HEK293 cells overexpressing TLR2 and TLR4 in vitro and in the mouse model of NTHi-induced pneumonia by using TLR2 and TLR4 knock-out mice in vivo.
|
18237405 |
2008 |