TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Disease: Renal Insufficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.420 Biomarker disease BEFREE TLR4 deficiency ameliorated renal dysfunction (serum BUN and creatinine) and tubular endothelial apoptosis determined by immunofluorescence staining of CD31 and TUNEL, and western blot of apoptotic protein (caspase-3, c-caspase-3, and Bax/Bcl-2 ratio). 30099700 2019
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.420 Biomarker disease CTD_human TLR4-mediated inflammation is a key pathogenic event leading to kidney damage and fibrosis in cyclosporine nephrotoxicity. 27585667 2017
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.420 Biomarker disease BEFREE The purpose of this review is to describe the basis for how ligand binding to TLR4 has the potential to cause renal dysfunction and the mechanisms by which this may take place in gram-negative sepsis. 27602552 2017
CUI: C1565489
Disease: Renal Insufficiency
Renal Insufficiency 		0.420 Biomarker disease HPO