Pneumonitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Multiple lines of evidence suggest that the excessive activation of Toll-like receptor 4 (TLR4) plays an important role in this detrimental lung inflammation.
|
30597258 |
2019 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
PA LPS is recognized by Toll-like receptors-4 (TLR4) and has been shown to induce lung inflammation in vivo.
|
29547450 |
2019 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, the results demonstrated that forsythoside B protects against LPS-induced ALI by attenuating inflammatory cell infiltration and suppressing TLR4/NF-κB-mediated lung inflammation.
|
30521962 |
2019 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Schaftoside, a natural flavonoid compound and a promising treatment for inflammation, has demonstrated potency against LPS-induced lung inflammation in mice; however, its action on TLR4-induced neuroinflammation and mitochondrial dynamics in microglia is still unknown.
|
30528467 |
2019 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Systemic release of high mobility group box 1, a TLR4 agonist, during the pneumonitis phase of the radiation response may act through TLR4 to contribute to fibroblast apoptosis resistance and thus interfere with wound resolution.
|
31020321 |
2019 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Toll-Like Receptor 4 (TLR-4) Pathway Promotes Pulmonary Inflammation in Chronic Intermittent Hypoxia-Induced Obstructive Sleep Apnea.
|
30293084 |
2018 |
Pneumonitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that cigarette smoke adversely affects cholesterol transport via an ABCA1-dependent mechanism in macrophages, enhancing TLR4/myeloid differentiation primary response gene 88 (Myd88) signaling and resulting in matrix metalloproteinase (MMP) up-regulation and exacerbation of pulmonary inflammation.
|
29906247 |
2018 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compared with wild-type (WT) mice, CS-induced pulmonary inflammation was unaltered in TLR2-deficient ( Tlr2<sup>-/-</sup>) and TLR4-deficient ( Tlr4<sup>-/-</sup>) mice.
|
29025711 |
2018 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The triggering receptor expressed by myeloid cells-1 activates TLR4-MyD88-NF-κB-dependent signaling to aggravate ventilation-induced lung inflammation and injury in mice.
|
29869715 |
2018 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The ventilated rats pre‑treated with anti‑TLR4 mAb exhibited markedly attenuated signs of ventilation‑induced injury, such as less lung inflammation and pulmonary edema, fewer cells in BALF, and lower levels of ILs and TNF‑α in BALF and plasma.
|
28204830 |
2017 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Growing sets of data from in vitro and in vivo models demonstrate the role of the innate immune system, especially Toll-like receptor 4 (TLR4) and TLR9, in lung inflammation induced following exposure to contaminants in agricultural environments.
|
28168324 |
2017 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that GOH treatment alleviates LPS-induced ALI via inhibiting pulmonary inflammation and apoptosis, a finding that might be associated with the inhibition of TLR4-mediated NF-κB and Bcl-2/Bax signalling pathways.
|
29050341 |
2017 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
HMGB1 translocation and release mediate cigarette smoke-induced pulmonary inflammation in mice through a TLR4/MyD88-dependent signaling pathway.
|
27807045 |
2017 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Desert dust induces TLR signaling to trigger Th2-dominant lung allergic inflammation via a MyD88-dependent signaling pathway.
|
26882889 |
2016 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TLR4-mediated pulmonary inflammation may contribute to development of ALI during OLT.
|
26491225 |
2015 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alternatively spliced myeloid differentiation protein-2 inhibits TLR4-mediated lung inflammation.
|
25576596 |
2015 |
Pneumonitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Thus, caveolin-1 Y14 phosphorylation was required for the interaction with TLR4 and activation of TLR4-MyD88 signaling and sepsis-induced lung inflammation.
|
24244013 |
2013 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation.
|
23475791 |
2013 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The innate immunity gene, toll-like receptor 4 (TLR4), protects against chronic pulmonary inflammation and tumorigenesis in mice, but the mechanism is unclear.
|
19925653 |
2009 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Quite surprisingly, the absence of TLR4 greatly diminished pulmonary inflammation and the same phenotype was observed in PAFR-/- animals.
|
18292574 |
2008 |
Pneumonitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A similar challenge with Hsp72 in TLR4 mutant mice did not stimulate the inflammatory response, stressing the importance of TLR4 in Hsp72-mediated lung inflammation.
|
17947709 |
2007 |