TLR4, toll like receptor 4, 7099

N. diseases: 1174; N. variants: 54
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Activation of TLR4 modulates vascular smooth muscle cells (VSMCs) phenotype and contributes to cardiovascular changes after sepsis. 31794773 2020
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE During hemorrhagic shock and sepsis, inflammation triggers the translocation of CIRP from the nucleus to the cytosol and its release to the extracellular space. eCIRP then induces inflammatory responses in macrophages, neutrophils, lymphocytes, and dendritic cells. eCIRP also induces endoplasmic reticulum stress and pyroptosis in endothelial cells by activating the NF-κB and inflammasome pathways, and necroptosis in macrophages via mitochondrial DNA damage. eCIRP works through the TLR4-MD2 receptors. 30645013 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Our results indicate that TFAM repairs mtDNA by blocking the TLR4/ROS/P38MAPK signaling pathway in inflammatory cells, thereby repairing septic tubular epithelial cells, and TFAM may serve as a new target for sepsis therapy. 31430762 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Sch B could increase miR-17-5p expression, promote inflammation, and decrease TLR4 expression in sepsis mice and LPS-induced macrophages. 30506107 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Dex pretreatment protects against LPS-induced ALI via inhibiting the activation of the TLR-4/NF-kB signaling pathway by upregulating the expression of Cav-1 downregulated by sepsis. 31545263 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway. 30957795 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Here we study the transcriptional patterns of tlr4 and of its modulator grp78 during human sepsis, and establish their correlations with the outcome of patients. 31314904 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE However, the response to a TLR2 ligand is muted in cohoused mice, whereas the response to a TLR4 ligand is greatly amplified, suggesting a basis for the distinct response to Listeria monocytogenes and sepsis. 31412243 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Our results further indicate that Toll-1 and Toll-7 bind multiple Spz proteins and also VSV, but they differentially affect adult survival after systemic infection, potentially because of sex-specific differences in Toll-1 and Toll-7 expression. 31088910 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The aim of this study was to investigate the effect of dexmedetomidine (DEX) on kidney injury in sepsis rats through the Toll-like receptor 4 (TLR4)/myeloid differential protein-88 (MyD88)/nuclear factor-κB (NF-κB)/inducible nitric oxide synthase (iNOS) signaling pathway. 31210339 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-<i>γ</i> Expression in CD38<sup>-/-</sup> Mice. 30915370 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE The expression of α7nAChR, toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1), and cleaved caspase-3 increased, peaking 24 h during sepsis. 31520992 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Increasing evidence indicates that Toll-like receptor 4 (TLR4) plays a key role in the development of sepsis. 30940475 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Interestingly, negative correlation between Toll-like receptor 4 (TLR4) and FAM46C in sepsis was observed. 30910647 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE As compared to sham surgery, polymicrobial sepsis dampened malignant tumor growth in wild-type (WT) mice, but neither in <i>Toll-like receptor 4</i> (<i>Tlr4)<sup>-/-</sup></i> nor in <i>Myd88<sup>-/-</sup></i> mice. 31646090 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 GeneticVariation disease BEFREE Specific point mutations in the human toll-like receptor 4 (TLR4) confer altered risk for diverse diseases including sepsis, aspergillosis and inflammatory bowel disease. 30885307 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE Moreover, platelet TLR4 has a prominent role as a sensor of high lipopolysaccharide circulating levels during sepsis and in the clearance of pathogens mediated by neutrophils. 30512209 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE This mechanism may be more critical for sepsis development than recognition of LPS by Toll-like receptor 4. 30691865 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 AlteredExpression disease BEFREE TLR4 is of particular interest, since over-stimulation of its pathway by excess lipopolysaccharide (LPS) molecules from the outer membranes of Gram-negative bacteria can result in sepsis, which causes millions of deaths each year. 31351116 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE These findings led us to speculate that TLR4-induced innate tolerance due to primary infection causes an immunosuppressive pathology in sepsis. 30671932 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Alkaline phosphatase (AP) is currently being investigated as an anti-inflammatory agent for detoxifying LPS through dephosphorylating lipid A, thus providing a potential treatment for managing both acute (sepsis) and chronic (metabolic endotoxemia) pathologies wherein aberrant TLR4/MD2 activation has been implicated. 31704704 2019
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Toll-like receptor 4 (TLR4)-a transmembrane pattern-recognition receptor responsible for propagating the immediate immune response to Gram-negative bacterial infection-plays a central role in the pathogenesis of sepsis and chronic inflammation-related disorders. 30276970 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE TLR4 recognizes lipopolysaccharide (LPS) and drives the secretion of inflammatory cytokines, often contributing to sepsis. 29343440 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Circulating histones contribute to inflammation, and to lethality in sepsis, a hyperinflammatory condition, by interacting with specific receptors, notably toll-like receptor 4 (TLR4). 29997623 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.600 Biomarker disease BEFREE Monophosphoryl lipid A (MPLA) is a detoxified TLR4 agonist that enhances innate antimicrobial immunity and improves survival following sepsis. 29741098 2018