|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the results of our study and meta-analysis suggest that SERPING1 is not a major genetic component of AMD or PCV in East Asians but is a genetic risk factor for AMD in Caucasians, providing evidence for an ethnic diversity in the genetic etiology of AMD.
|
25800435 |
2015 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The current meta-analysis shows that the SERPING1 rs2511989 polymorphism may have a positive effect on the risk of AMD, especially among Caucasians.
|
25352749 |
2014 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Including genetic variation in the model shows that one significant SNP (rs2649663) 5' of the SERPING1 gene is associated with C1inh levels though this SNP is not associated with AMD.
|
21852020 |
2012 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether there is an association between CFH, ARMS2, HTRA1, VEGF, SERPING1 or C3 genotypes and patient response to treatment with intravitreal bevacizumab for neovascular age-related macular degeneration (AMD).
|
22594510 |
2012 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
With the sample size of our study, no relationship was found for AMD and the SNPs tested in complement 3 (C3); serpin peptidase inhibitor, clade G, member 1 (SERPING1); vascular endothelial growth factor (VEGF); cholesterol ester transfer protein (CETP); lipoprotein lipase (LPL); hepatic lipase (LIPC); and metallopeptidase inhibitor 3 (TIMP3) genes.
|
22618592 |
2012 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although we compared the genotypic distributions of rs2511989 in typical AMD and PCV patients against 2 independent control groups (cataract patients and healthy Japanese individuals), SERPING1 rs2511989 was not significantly associated with typical AMD (P = 0.932 and 0.513, respectively) or PCV (P = 0.505 and 0.141, respectively).
|
21526158 |
2011 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several variants in the complement cascade genes (complement factor H [CFH], C2, C3, CFB, and Serping1) have been reported to associate with age-related macular degeneration (AMD).
|
20122735 |
2010 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SERPING1 SNPs rs1005510 and rs2511989 were significantly associated with neovascular AMD in our cohort, with rs1005510 conferring an adverse risk effect (OR 1.49, 95% CI 1.18 to 1.88) and rs2511989 conferring a protective effect (OR 0.73, 95% CI 0.59 to 0.90).
|
20606025 |
2010 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our risk model includes six SNPs in CFH, C3, HTRA1 and SERPING1, showing independent effects, which together account for 45% of risk of developing AMD (p=1.65×10(-50)) with a combined population attributable risk of 87%.
|
20576771 |
2010 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An association study of SERPING1 gene and age-related macular degeneration in a Han Chinese population.
|
20062564 |
2010 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Evaluation of haplotypes across SERPING1 did not reveal association with AMD (p=0.14-0.97).
|
19169411 |
2009 |
|
Age related macular degeneration
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a small number of eyes (n = 7 AMD and n = 7 control) AMD affection status was correlated with increased abundance of choroidal C1INH.
|
19607829 |
2009 |
|
Age related macular degeneration
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The SNP variant rs2511989, located within intron six of the SERPING1 gene, showed highly significant genotypic association with age-related macular degeneration (uncorrected p=4.0x10(-5), corrected p=0.00372).
|
18842294 |
2008 |