TMPRSS2, transmembrane serine protease 2, 7113

N. diseases: 69; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005967
Disease: Bone neoplasms
Bone neoplasms 		0.010 Biomarker group BEFREE TMPRSS2-ERG fusions confer efficacy of enzalutamide in an in vivo bone tumor growth model. 31638934 2019
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.010 GeneticVariation disease BEFREE We detected <i>n</i> = 40 fusion-positive cases (7.7%) with TMPRSS2::ERG in prostate cancer being most prevalent (<i>n</i> = 9/40; 22.5%), followed by other gene fusions identified in cancers of unknown primary (<i>n</i> = 6/40; 15.0%), adenoid cystic carcinoma (<i>n</i> = 7/40; 17.5%), and pancreatic cancer (<i>n</i> = 7/40; 17.5%). 31491926 2019
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.010 AlteredExpression disease BEFREE Six genes (LGALS3BP, MSR1, CD163, LOXL2, LOXL3 and LOXL4) were upregulated, and four genes (DMBT1, PRSS12, TMPRSS2 and SCARA5) were downregulated in ESCC. 31217847 2019
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.010 GeneticVariation disease BEFREE We detected <i>n</i> = 40 fusion-positive cases (7.7%) with TMPRSS2::ERG in prostate cancer being most prevalent (<i>n</i> = 9/40; 22.5%), followed by other gene fusions identified in cancers of unknown primary (<i>n</i> = 6/40; 15.0%), adenoid cystic carcinoma (<i>n</i> = 7/40; 17.5%), and pancreatic cancer (<i>n</i> = 7/40; 17.5%). 31491926 2019
CUI: C1264610
Disease: Infectious peritonitis
Infectious peritonitis 		0.010 Biomarker disease BEFREE Generating and evaluating type I interferon receptor-deficient and feline TMPRSS2-expressing cells for propagating serotype I feline infectious peritonitis virus. 31539770 2019
CUI: C1608408
Disease: Malignant transformation
Malignant transformation 		0.010 Biomarker phenotype BEFREE The process is: (<i>i</i>) specified by the sequence of chimeric RNA involved, (<i>ii</i>) facilitated by physiological hormone levels, (<i>iii</i>) permissible regardless of intrachromosomal (<i>TMPRSS2-ERG</i>) or interchromosomal (<i>TMPRSS2-ETV1</i>) fusion, and (<i>iv</i>) can occur in normal cells before malignant transformation. 30538195 2018
CUI: C0007124
Disease: Noninfiltrating Intraductal Carcinoma
Noninfiltrating Intraductal Carcinoma 		0.010 Biomarker disease BEFREE Expert commentary: The new additions to the 2016 WHO tumor classification, which include pathological definition of Intraductal carcinoma of the prostate (IDC-P) and of a new grading system for PCa, as well as identification of molecular markers, such as TMPRSS2-ERG and AR-V7, may pave the way to personalized therapy for patients with prostate tumors. 28598696 2017
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.010 Biomarker disease BEFREE Hyperglycemia Promotes TMPRSS2-ERG Gene Fusion in Prostate Cancer Cells <i>via</i> Upregulating Insulin-Like Growth Factor-Binding Protein-2. 29163372 2017
CUI: C0033575
Disease: Prostatic Diseases
Prostatic Diseases 		0.010 Biomarker group BEFREE Additional studies are needed to explore mechanisms for the development of TMPRSS2:ERG positive disease.Prostate 77: 647-653, 2017. 28102015 2017
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa 		0.010 Biomarker disease BEFREE The ability of EV analysis to accurately reflect prostate tissue mRNA expression was examined by comparing urinary EV TMPRSS2:ERG exoRNA from pre-radical prostatectomy (RP) patients versus corresponding RP tissue in 21 patients. 27144529 2016
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.010 Biomarker group BEFREE TMPRSS2-deficient mice demonstrated the relevance of TMPRSS2 for pneumotropism and pathogenicity of H1N1 and H7N9 virus infections. 26095298 2016
CUI: C0596240
Disease: Cancer Pain
Cancer Pain 		0.010 Biomarker phenotype BEFREE We show that TMPRSS2 expression is not only dramatically increased in the primary cancers of patients but TMPRSS2 immunopositivity is also directly correlated with cancer pain severity in these patients. 25734995 2015
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.010 AlteredExpression phenotype BEFREE TMPRSS2 induced proteolytic activity, activated trigeminal neurons, and produced marked mechanical hyperalgesia when administered into the hind paw of wild-type mice but not PAR2-deficient mice. 25734995 2015
CUI: C3665951
Disease: Influenza due to Influenza A virus subtype H7N9
Influenza due to Influenza A virus subtype H7N9 		0.010 Biomarker disease BEFREE Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza. 25904605 2015
CUI: C0398791
Disease: Nijmegen Breakage Syndrome
Nijmegen Breakage Syndrome 		0.010 GeneticVariation disease BEFREE In conclusion, our study identifies an association of NBS1 expression with surrogates of genomic instability in prostate cancer including TMPRSS2-ERG rearrangements and PTEN deletion. 24510842 2014
CUI: C0853879
Disease: Invasive carcinoma of breast
Invasive carcinoma of breast 		0.010 AlteredExpression disease BEFREE The ERG-induced mesenchymal-like signature positively correlated with TMPRSS2-ERG prostate tissues and invasive breast cancer mRNA expression datasets reflecting a general ERG-driven pattern of malignancy. 24504051 2014
CUI: C0085750
Disease: Adenosis of Breast
Adenosis of Breast 		0.010 AlteredExpression disease BEFREE Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate. 23664537 2013
CUI: C0334050
Disease: Adenosis
Adenosis 		0.010 AlteredExpression disease BEFREE Immunohistochemical evaluation of TMPRSS2-ERG gene fusion in adenosis of the prostate. 23664537 2013
CUI: C0553580
Disease: Ewings sarcoma
Ewings sarcoma 		0.010 Biomarker disease BEFREE We performed an integrative study of genome-wide DNA-binding and transcription data in EWSR1/FLI1 expressing ES and TMPRSS2/ERG containing PC cells. 23940108 2013
CUI: C4727916
Disease: H3N2 influenza
H3N2 influenza 		0.010 Biomarker disease BEFREE Also, after infection with mono-basic H3N2 influenza A virus body weight loss and survival was less severe in Tmprss2 mutant compared to wild type mice. 24348248 2013
CUI: C0040580
Disease: Tracheal Diseases
Tracheal Diseases 		0.010 Biomarker group BEFREE Similarly, coexpression of ACE2, the SARS-coronavirus receptor, and TMPRSS2 was frequently found in the upper and lower aerodigestive tract, with the exception of the vocal folds, epiglottis and trachea. 22558251 2012
CUI: C0282687
Disease: Hemorrhagic Fever, Ebola
Hemorrhagic Fever, Ebola 		0.010 Biomarker disease BEFREE Here, we show that cathepsin B/L inhibitors markedly reduce 293T cell infection driven by the GPs of all EBOV species, independent of the type II transmembrane serine protease TMPRSS2, which cleaved but failed to activate EBOV-GPs. 22222211 2012
CUI: C0002793
Disease: Anaplasia
Anaplasia 		0.010 Biomarker disease BEFREE These findings provide a working model in which TMPRSS2-ERG plays a critical role in cancer progression by disrupting lineage-specific differentiation of the prostate and potentiating the EZH2-mediated dedifferentiation program. 20478527 2010
CUI: C0007130
Disease: Mucinous Adenocarcinoma
Mucinous Adenocarcinoma 		0.010 Biomarker disease BEFREE Here, we used break-apart fluorescence in situ hybridization to assess TMPRSS2 and ETS aberrations in a series of select histologic variants: foamy gland carcinoma (N=17), ductal adenocarcinoma (N=18), mucinous carcinoma (N=18), and small cell carcinoma (N=7). 19465903 2009
CUI: C0206685
Disease: Acinar Cell Carcinoma
Acinar Cell Carcinoma 		0.010 GeneticVariation disease BEFREE The presence of the TMPRSS2-ERG gene fusion in some cases of prostatic ductal adenocarcinoma supports the concept that ductal adenocarcinoma and acinar adenocarcinoma may be related genetically. 19151660 2009