TMPRSS2, transmembrane serine protease 2, 7113

N. diseases: 69; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021400
Disease: Influenza
Influenza
0.050 Biomarker disease BEFREE This study identifies TMPRSS2 as the major HA-activating protease of IAV in human airway cells and IBV in type II pneumocytes and as a potential target for the development of novel drugs to treat influenza infections.<b>IMPORTANCE</b> Influenza A viruses (IAV) and influenza B viruses (IBV) cause significant morbidity and mortality during seasonal outbreaks. 31391268 2019
CUI: C0021400
Disease: Influenza
Influenza
0.050 Biomarker disease BEFREE TMPRSS2: A potential target for treatment of influenza virus and coronavirus infections. 28778717 2017
CUI: C0021400
Disease: Influenza
Influenza
0.050 Biomarker disease BEFREE Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza. 25904605 2015
CUI: C0021400
Disease: Influenza
Influenza
0.050 Biomarker disease BEFREE Tmprss2 is essential for influenza H1N1 virus pathogenesis in mice. 24348248 2013
CUI: C0021400
Disease: Influenza
Influenza
0.050 AlteredExpression disease BEFREE In sum, our results show that TMPRSS2 and HAT are expressed by important influenza and SARS-coronavirus target cells and could thus support viral spread in the human host. 22558251 2012