|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thymosin β4 has tumor suppressive effects and its decreased expression results in poor prognosis and decreased survival in multiple myeloma.
|
19833631 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
At mRNA level, the differences in Tβ(4) expression between the surrounding colon mucosa and the tumors samples were not significant.
|
22233609 |
2012 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
The treatment with N-(β-D-Glucopyranosyl)-N2-acetyl-S-nitroso-D, L-penicillaminamide (SNAP-1), to generate NO, enhanced the transcription of Tβ4 and cancer cell migration.
|
25271630 |
2014 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Thus, Tβ4 provided a potential target of opportunity for cancer management, especially for cancer metastasis therapy.
|
22856429 |
2012 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Thymosinβ-4(Tβ4) is an actin-sequestering protein involved in tumor malignancy.
|
31048733 |
2019 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Human thymosin beta 4 (TB4) is a small acidic peptide involved in angiogenesis, wound healing, cancer metastasis and cardiac repair.
|
17923415 |
2007 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
These findings show that the thymosin beta 4 and beta 10 genes are constitutively expressed at higher levels in embryonic/neoplastic as compared to normal/benign tissues and that thymosin in beta 10 in particular may be a new molecular marker for renal-cell carcinoma as well as other malignancies.
|
2071228 |
1991 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Expression patterns of Thymosin β4 and cancer stem cell marker CD133 in ovarian cancers.
|
23055022 |
2013 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Thymosin beta 4 expression increased with grade of malignancy in gliomas.
|
24355709 |
2014 |
|
Malignant Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Thymosin beta-4 (Tβ4), actin-sequestering protein, plays important roles in many cellular functions including cancer cell migrations.
|
22328534 |
2012 |
|
Malignant Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Correction: Hypoxia/reoxygenation-experienced cancer cell migration and metastasis are regulated by Rap1- and Rac1-GTPase activation <i>via</i> the expression of thymosin beta-4.
|
30680073 |
2018 |
|
Colorectal Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
MALDI-imaging reveals thymosin beta-4 as an independent prognostic marker for colorectal cancer.
|
26556858 |
2015 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that the expression of thymosin β4 is highly related with tumorigenesis of certain tumors including the osteosarcoma and colorectal cancers.
|
20975530 |
2011 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that upregulation of Tbeta-4, by promoting the disruption of cell-cell adhesion and a consequential activation of the beta-catenin signaling, could be a key event in the acquisition of growth advantages as well as invasive phenotypes in human colorectal carcinomas.
|
15235586 |
2004 |
|
Colorectal Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
This study was aimed at evaluating the correlation between Tβ(4) immunoractivity and colorectal cancer, with particular attemption to tumor cells undergoing epithelial-mesenchymal transition.
|
22233609 |
2012 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Together, our results show for the first time that in vivo silencing of Tβ4 expression by its shRNA generated after adenoviral infection can suppress CRC growth.
|
25124811 |
2014 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In this study, we show that Tβ4 was significantly overexpressed in colorectal cancer tissues compared to adjacent normal tissues and high levels of Tβ4 were correlated with stage of colorectal cancer, and that Tβ4 expression was associated with morphogenesis and EMT.
|
25218472 |
2014 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
In colorectal cancer, the association of a high expression of Tβ4 with epithelial-mesenchymal transition was observed.
|
23045970 |
2012 |
|
Colorectal Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin beta-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis.
|
16501890 |
2006 |
|
Fibrosis, Liver
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The expression of Tβ4 was significantly reduced during the progression of liver fibrosis.
|
25060912 |
2014 |
|
Fibrosis, Liver
|
0.080 |
Biomarker
|
disease |
BEFREE |
Thymosin β4 suppresses CCl<sub>4</sub> -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II.
|
29972714 |
2018 |
|
Fibrosis, Liver
|
0.080 |
Biomarker
|
disease |
BEFREE |
Taken together, findings in our present studies suggested that exogenous Tβ4 alleviated BDL-induced cholestatic liver fibrosis through downregulating PDGF/PDGFR and TGFβ/Smad pathways.
|
31542221 |
2020 |
|
Fibrosis, Liver
|
0.080 |
Biomarker
|
disease |
BEFREE |
Understanding the potential effects and regulatory mechanism of Tβ4 in liver fibrosis might help to provide a novel treatment for patients with liver fibrosis.
|
28978161 |
2017 |
|
Fibrosis, Liver
|
0.080 |
Biomarker
|
disease |
BEFREE |
Therefore, Tβ4 had the effect of reversing liver fibrosis.
|
30779097 |
2019 |
|
Fibrosis, Liver
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our data indicate that Tβ4 might be an effective anti-fibrotic drug for the treatment of liver fibrosis.
|
28965947 |
2017 |