TMSB4X, thymosin beta 4 X-linked, 7114

N. diseases: 130; N. variants: 0
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 Biomarker disease BEFREE Taken together, findings in our present studies suggested that exogenous Tβ4 alleviated BDL-induced cholestatic liver fibrosis through downregulating PDGF/PDGFR and TGFβ/Smad pathways. 31542221 2020
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 Biomarker disease BEFREE Therefore, Tβ4 had the effect of reversing liver fibrosis. 30779097 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 Biomarker disease BEFREE Thymosin β4 suppresses CCl<sub>4</sub> -induced murine hepatic fibrosis by down-regulating transforming growth factor β receptor-II. 29972714 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 Biomarker disease BEFREE Therefore, we hypothesize that Tβ4 influences circRNAs in liver fibrosis. 30481761 2018
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 Biomarker disease BEFREE Understanding the potential effects and regulatory mechanism of Tβ4 in liver fibrosis might help to provide a novel treatment for patients with liver fibrosis. 28978161 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 Biomarker disease BEFREE Our data indicate that Tβ4 might be an effective anti-fibrotic drug for the treatment of liver fibrosis. 28965947 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 AlteredExpression disease BEFREE Treatment with the exogenous Tβ4 peptide inhibits the proliferation and migration of activated HSCs and reduces liver fibrosis, indicating it has an antifibrotic action. 27450733 2016
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.080 AlteredExpression disease BEFREE The expression of Tβ4 was significantly reduced during the progression of liver fibrosis. 25060912 2014