|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
<b>Materials and Methods:</b> Healthy human colonic mucosal strips (4 × 10 mm) were incubated in carbogenated culture medium at 37°C for 16 h. Proinflammatory cytokines TNFα and IL-1β (each 10 ng/mL) were used to induce colitis in mucosal strips, and the effects of Panx1 and P2X7R on cytokines-induced tissue damage were determined in the presence of the Panx1 channel blocker <sup>10</sup>Panx1 (100 μM) and P2X7R antagonist A438079 (100 μM).
|
30127744 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
(2019) identify important roles of TNF-producing T cells as both regulators of gut development and potential inducers of colitis.
|
30784573 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colitis was induced in mice by transfer of CD4+CD45RB<sup>hi</sup> to FcγR<sup>-/-</sup>Rag1<sup>-/-</sup> or Rag1<sup>-/-</sup> littermates; mice were given different antibodies against TNF or isotype (control) antibodies and disease activity index scores were determined.
|
28756234 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor Necrosis Factor Ligand-Related Molecule 1A Regulates the Occurrence of Colitis-Associated Colorectal Cancer.
|
29796912 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A DNAzyme that prevents expression of GATA3 reduces colitis in mice, independently of TNF, and reduces levels of cytokines in the colon.
|
27639807 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Additionally, huperzine A was effective to reverse colitis-induced high lucigenin-enhanced CL values and serum TNF-α levels.
|
23810507 |
2013 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, these agents decreased the activity of MPO (<i>p</i> ˂ .001), TNF-α (<i>p</i> ˂ .001) and the expression level of p-NF-kB (<i>p</i> ˂ .001) in rat colon tissue compared with the acetic acid group.<b>Conclusion:</b> It is proposed that the anti-inflammatory activity of dapsone on acetic acid-induced colitis in rats may involve the inhibition of NF-kB pathway.
|
31621446 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Administration of LMWH-NP at 500 IU/kg has markedly improved the clinical activity as compared to LMWH while similarly pathophysiological indicators revealed increased therapeutic outcome in presence of NP compared to LMWH alone: Myeloperoxidase (Colitis control: 10 480 ± 5335, LMWH-PEMT-A NP: 1507 ± 2165, LMWH-PEMT-B NP: 382 ± 143, LMWH: 8549 ± 5021 units/g) and tumor necrosis factor: (Colitis control: 1636 ± 544, LMWH-PEMT-A NP: 511 ± 506, LMWH-PEMT-B NP: 435 ± 473, LMWH: 1110 ± 309 pg/g).
|
28509629 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because prostaglandin E2 and tumor necrosis factor-α are also elevated in colitis, we determined whether these factors could induce ID1 transcription in cultured endothelial cells.
|
26348574 |
2015 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both the CSF-1 and the TNFα gene sets were enriched in the colonic mucosal transcriptomes of Crohn's disease and in mouse colitis, and expression of both gene sets was highest in patients who did not respond to anti-TNFα therapy.
|
31710624 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Contrary to expectations, but in line with some reports, the neutralization of TNFα aggravated disease symptoms in the acute phase of colitis and increased TNFα concentration in colon tissue of healthy mice.
|
28039805 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CRYAB was found to be significantly decreased in the inflamed mucosa from IBD patients and DSS-induced colitis in mice, and negatively correlated with the levels of TNF-α and IL-6, respectively.
|
31481750 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cux1 expression increased in cultured intestinal epithelial cells stimulated with tumor necrosis factor alpha (TNFα), in the mouse intestinal epithelium during experimental colitis and in human IBD patient samples.
|
20848487 |
2010 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
DAI evaluation, colon length, colon tissue morphology, histologic damage scores and relative protein concentrations (MPO, TNF-α and IL-1β) demonstrated that the Alg/Chi/IL-1Ra microcapsules alleviated DSS-induced colitis in mice.
|
30779979 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
DSS treatment increased IL-10 and TNF levels during the acute phase of colitis, and increased IL-10 but reduced TNF levels during the recovery phase in Egfr(fl/fl)LysM-Cre mice.
|
24391216 |
2014 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Effects of rectally injected prostaglandin E2 (PGE2) in rats with dextran sodium sulphate (DSS)-induced colitis were investigated in terms of histopathology, local myeloperoxidase (MPO) activity, local mRNA expression of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and growth-regulated gene produced/cytokine-induced neutrophil chemoattractant (GRO/CINC)-1, and secretion of TNF-alpha and GRO/CINC-1.
|
10632972 |
2000 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression and activation of Smad1, a positive regulator of hepcidin transcription, were assessed during colitis and following administration or neutralization of TNFα.
|
22675442 |
2012 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Functionally enhanced siRNA targeting TNFα attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice.
|
22044934 |
2012 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore BTZO-15 reduced the ulcerated area and rectal MPO activity in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rats without affecting rectal TNF-α levels.
|
21853095 |
2011 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, macrophages from both types of KI mice displayed defects in TNF-α-induced Atg16L1T300A cleavage, increased retention of bacteria, bacterial dissemination, and <i>Salmonella-</i>induced colitis.
|
28202618 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Guanylin was diminished early in colitis in vivo and tumor necrosis factor α suppressed guanylin mRNA and protein in intestinal goblet cell-like HT29-18-N2 cells.
|
24244444 |
2013 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we provide evidence that the mouse fecal microbiome is shaped, in part, by sex, age and TNF production and that these effects correlate with the degree of animals' colitis.
|
29175304 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we use wildtype (WT) and mice lacking Tnf (Tnf-/-) in an acute TNBS colitis model to investigate the role of TNF in colitis and how its presence or absence affects the colonic microbiota.
|
25775453 |
2015 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that the oral administration of transgenic low-alkaloid tobacco expressing the contra-inflammatory cytokine human interleukin-10 (hIL-10) reduces the severity of colitis by down-regulating TNF-alpha expression directly at the sites of inflammation in IBD-susceptible IL-10(-/-) mice. hIL-10 expressed in plants is biologically active and displays resistance to gastrointestinal degradation.
|
17207256 |
2007 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we use the mucosal delivery of Lactococcus lactis carrying an anti-TNFα scFv expression plasmid on a DSS-induced colitis model in mice.
|
31238939 |
2019 |