Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One of the well-known physiological substances that induce the PAI-1 gene is tumor necrosis factor-alpha, which also induces other possible risk factors of atherosclerosis, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1.
|
9187938 |
1997 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been suggested that proinflammatory cytokines such as tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1), as well as adhesion molecules such as beta2-integrins and CD14, play a role in the pathogenesis of atherosclerosis.
|
9863542 |
1998 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present findings support the notion that LDL may activate arterial expression of TNF-alpha and suggest 1 possible mechanism for the inflammatory response in the early stages of atherosclerosis.
|
11031205 |
2000 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNFA and TNFB polymorphisms are unlikely to contribute to progression of atherosclerosis in a way clinically important.
|
11257271 |
2001 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is elaborated by VSMC in atherosclerosis and following angioplasty.
|
11728452 |
2001 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggested that though TNF-alpha G-238A and G-308A polymorphisms were not involved in the pathogenesis of type 2 DM, type 2 diabetic patients carrying TNFA-A or TNF-308*2 genotype might be more susceptible to diabetic complications such as atherosclerosis.
|
12753658 |
2003 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is a key cytokine in the inflammation process of atherosclerosis.
|
12818408 |
2003 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) is an important cytokine in the inflammation process of atherosclerosis.
|
14593215 |
2003 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis.
|
15292354 |
2004 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Through screening expression patterns of typical genes involved in atherosclerosis and foam cell generation, we could demonstrate that mRNA levels of cyclooxygenase-2, interleukin 1beta, and tumor necrosis factor-alpha were increased in a time- and dose-dependent manner in U937 macrophages treated with TCDD, like oxLDL, and that these changes accompanied significantly elevated levels of matrix-degrading metalloproteinases (MMP)-1, MMP-3, MMP-12, and MMP-13.
|
15531779 |
2004 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The involvement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in atherosclerosis.
|
15808757 |
2005 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha-induced endothelial injury, which is associated with atherosclerosis, is mediated by intracellular reactive oxygen species.
|
16224057 |
2005 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha), are suggested to have an important role in the process of atherosclerosis.
|
16487030 |
2006 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, obesity and TNF-alpha up-regulation of PAI-1 expression in human hepatocytes may contribute to the impairment of the fibrinolytic system, leading to the development of atherosclerosis and liver fibrosis in insulin-resistant individuals.
|
17046548 |
2006 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied how the levels of intercellular adhesion molecule-1 (ICAM-1), one of the key molecules in the development of atherosclerosis, might be affected by paeonol in tumor necrosis factor-alpha (TNF-alpha)-activated human umbilical vein endothelial cells (HUVECs).
|
17276892 |
2007 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Inflammation and atherosclerosis: the role of TNF and TNF receptors polymorphisms in coronary artery disease.
|
17346438 |
2007 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the association of TNF-alpha gene promoter polymorphisms, G-238A, G-308A, C-857T, C-863A, and T-1031C, with metabolic syndrome and surrogate markers of atherosclerosis in Japanese patients with type 2 diabetes.
|
17347550 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), are implicated in the development of atherosclerosis.
|
17460178 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interaction between members of the tumor necrosis factor (TNF) superfamily and their receptors elicits diverse biologic actions that participate in atherosclerosis development.
|
17485328 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peroxisome proliferator-activated receptor gamma (PPARgamma) is a transcription factor implicated in the expression of proinflammatory cytokines in atheroma-associated cells, and the expression of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha) and matrix metalloproteinases (MMPs), represents a critical step in atherogenesis and atherosclerosis.
|
17892998 |
2007 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recently, TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF superfamily, has been implicated in the development of atherosclerosis since it has been detected in normal and diseased atherosclerotic tissue.
|
18061141 |
2008 |
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha and local activation of the renin-angiotensin system may contribute to insulin resistance and atherosclerosis.
|
18078928 |
2008 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Costimulatory molecules of the tumor necrosis factor superfamily such as CD40/CD40L and OX40/OX40L have been implicated in atherosclerosis.
|
18285570 |
2008 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lymphotoxin alpha (LTA), one of the tumor necrosis factor family proteins, is an important proinflammatory cytokine and appears to play a putative role in the inflammatory process of atherosclerosis.
|
18349535 |
2008 |
Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied how the level of vascular cell adhesion molecule-1 (VCAM-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by bisacurone in tumor necrosis factor-alpha (TNF-alpha)-activated human umbilical vein endothelial cells (HUVECs).
|
18602074 |
2008 |