TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE For example, tumor necrosis factor inhibitors are quite successful in the treatment of rheumatoid arthritis (RA), Behçet's disease (BD), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) but not in that of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), Sjögren's syndrome (SS) and antineutrophil cytoplasmic antibody-associated vasculitis (AAV), conversely, RA shares genetic backgrounds more with SLE, SSc, SS and AAV than BD, AS and PsA. 29623390 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE To compare baseline disease activity and treatment effectiveness in biologic-naive patients with nonradiographic axial spondyloarthritis (nr-axSpA) and ankylosing spondylitis (AS) who initiate tumor necrosis factor inhibitor (TNFi) treatment and to study the role of potential confounders (e.g., HLA-B27 status). 27909080 2017
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE MiRNA-5196 expression was significantly higher in patients with RA and AS before TNF-α therapy than in those following anti-TNF-α therapy and healthy controls. 29744553 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE The results of differential linkage disequilibrium with HLA-B27 subtypes suggest that B27 itself remains the primary gene for AS susceptibility, and TNFA and MICA are not involved in the pathogenesis of the disease. 10717805 2000
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE Besides TNF, the IL-23/IL-17 axis is emerging as an important inflammatory pathway in SpA, as a SNP in the IL-23R locus has been associated with developing AS, mice overexpressing IL-23 develop SpA-like features and IL-17 blockade has been shown to be efficacious for AS patients in a phase II trial. 23969080 2014
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE The -308.1 polymorphism in the promoter region of the tumor necrosis factor gene is associated with ankylosing spondylitis independent of HLA-B27. 10332976 1999
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 AlteredExpression disease BEFREE High disease activity AS patients were treated with TNFα inhibitors for 12 weeks. 29546695 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Baseline and biannual radiographs were randomized with radiographs of TNF-naive AS patients and scored in chronologic order according to modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). 27696754 2017
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE To compare patients affected by ankylosing spondylitis (AS) treated with anti-TNF-α for two years with controls in terms of Achilles tendon stiffness, ultrasound structure and thickness. 31471416 2020
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE The tmTNFalpha-transgenic/TNFalpha-KO mice were born with crinkled tails and spinal deformities similar to those in ankylosing spondylitis. 16947419 2006
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis. 19758203 2009
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Comparative Efficacy of Tumor Necrosis Factor-α Inhibitors in Ankylosing Spondylitis: A Systematic Review and Bayesian Network Metaanalysis. 29335342 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 AlteredExpression disease BEFREE Incubation of AS and control PBMC with phytohaemagglutinin (PHA) led to upregulation of TGFbeta1, interleukin-10, tumour necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) assessed by ELISA. 15479754 2005
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE Using the Ankylosing Spondylitis Disease Activity Score (ASDAS), we assessed the prevalence of ID in ax-SpA patients treated with TNFα inhibitors (TNFi). 28880727 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 AlteredExpression disease BEFREE These results indicated that HDAC3 was involved in the regulation of the underlying molecular mechanism of AS by forming a negative feedback loop with miR-130a and enhancement of TNF-1α expression. 26531724 2016
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Improved knowledge of the immune/inflammatory pathways, which characterise the pathophysiology of rheumatoid arthritis (RA) and seronegative spondyloarthropathies (SpA), such as ankylosing spondylitis (AS) and psoriatic arthritis (PsA), have provided the link between inflammation and bone loss, via a complex network of bone cells, T and B cells, pro-inflammatory cytokines such as TNF-α, IL1, IL6, IL17, IL23, costimulator molecules, signalling pathways including both RANKL/RANK/OPG and Wnt signallings. 30557124 2019
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Although it has been clear for twenty-five years that TNF plays a major role in RA and AS, two major questions remain unanswered: (1) What mechanism underlies the loss of control of TNF levels in patients? 26321488 2016
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE ORs of various comparisons indicate that there is no association between TNF-α -238, -308 polymorphisms and AS susceptibility in the overall population and in the subgroup of Asian and non-Asian descent. 22661255 2013
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE In addition, the IL-10-819  C/T and TNF-α-857 C/T polymorphisms also confer susceptibility to AS, especially in Asian population. 30322951 2018
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE No relationship was found between TNF-alpha promoter 238 polymorphisms and AS in HLA-b27+ population. 20535510 2010
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Both diseases are mediated in part by TNF, since anti-TNF therapies have proved effective in both AS and RA. 19822042 2010
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 AlteredExpression disease BEFREE More importantly, the TIPE2 mRNA expression levels were negatively correlated with TNF-α, hsCRP and bath ankylosing spondylitis disease activity index (BASDAI) (r=-0.3574, P=0.0159; r=-0.3174, P=0.0336; r=-0.6000, P<0.0001; respectively) in the AS patients. 27816498 2017
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Meanwhile, it seems that TNF inhibitors in ankylosing spondylitis may present a better safety profile than we thought. 31172410 2019
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 GeneticVariation disease BEFREE To investigate the influence of patient characteristics on the course of spinal radiographic progression in a large prospective longitudinal cohort study of ankylosing spondylitis (AS) patients treated long-term with TNF-α inhibitors. 28640818 2017
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis
0.100 Biomarker disease BEFREE Serum TNF-α level was lower in patients with AS (151 pg/ml) than in controls (263 pg/ml), because more patients with AS had undetectable serum TNF-α (66 vs 25%, p < 0.001). 25028373 2014