Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because of the involvement of tumor necrosis factor (TNF) in cartilage damage and the localization of the TNF genes in the proximity of the HLA-B locus, we investigated the association between AS and TNF alleles.
|
1672816 |
1991 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because of the localization, in the proximity of the HLA-B locus, and the biological activities of TNF-alpha, we investigated the association between AS and a single base polymorphism located at position -308 of the TNF-alpha gene.
|
8033419 |
1994 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This protective effect of variant promoter alleles could be related to differences in TNFalpha production or could reflect the association of different B27 haplotypes with ankylosing spondylitis.
|
9704649 |
1998 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Pe-TNF transgenic mouse model provides a unique opportunity to explore potential mechanisms whereby TNF-alpha may initiate an autoimmune arthritis resembling ankylosing spondylitis.
|
9568723 |
1998 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of its gene location, in the proximity of the HLA-B locus, and biological effects, tumor necrosis factor (TNF) genes are potential candidates for additive susceptibility factors to AS.
|
9583811 |
1998 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -308.1 polymorphism in the promoter region of the tumor necrosis factor gene is associated with ankylosing spondylitis independent of HLA-B27.
|
10332976 |
1999 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we conclude that the association between TNF-238G and AS is secondary to the HLA-B27 gene and that TNF-238 and-TNF-376 alleles are not likely to be involved in the susceptibility to AS.
|
10027781 |
1999 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results of differential linkage disequilibrium with HLA-B27 subtypes suggest that B27 itself remains the primary gene for AS susceptibility, and TNFA and MICA are not involved in the pathogenesis of the disease.
|
10717805 |
2000 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results confirm previous observations in the southern German population of association between TNF promoter region polymorphisms and AS, but the lack of association in the English population suggests that these polymorphisms themselves are unlikely to be directly involved.
|
11196671 |
2000 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that the polymorphism variation in the TNF-alpha promoter -238.2(A) influences disease susceptibility in B27 negative primary AS but had no effect in our B27 positive AS population.
|
11409121 |
2001 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism.
|
11114280 |
2001 |
Ankylosing spondylitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Incubation of AS and control PBMC with phytohaemagglutinin (PHA) led to upregulation of TGFbeta1, interleukin-10, tumour necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) assessed by ELISA.
|
15479754 |
2005 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The tmTNFalpha-transgenic/TNFalpha-KO mice were born with crinkled tails and spinal deformities similar to those in ankylosing spondylitis.
|
16947419 |
2006 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A great deal of evidence has shown that non-human leucocyte antigen (HLA)-B27 genes may play crucial roles in the aetiology of ankylosing spondylitis (AS), but there is little evidence of a relationship with tumour necrosis factor (TNF)alpha gene variation.
|
17472990 |
2007 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A total of 54 patients with RA, 10 with PsA and 22 with AS were genotyped by polymerase chain reaction for the -308 TNFalpha promoter polymorphism.
|
16720636 |
2007 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
A novel gene variation of TNFalpha associated with ankylosing spondylitis: a reconfirmed study.
|
17472990 |
2007 |
Ankylosing spondylitis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results indicated that TLR4 protein and mRNA levels were significantly higher in AS patients than in healthy controls; however, there was no significant difference between human leucocyte antigen (HLA)-B27-positive and -negative AS patients, as well as serum levels of TNF-alpha, IL-12 and sTRAIL.
|
17459079 |
2007 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-A33-B58-Cw10 haplotypes associated TNF-alpha promoter -308G/A polymorphism might play an important role in disease pathogenesis of AS in Chinese population, partially related to a driving force of a higher TNF-alpha production.
|
18719920 |
2008 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis.
|
19758203 |
2009 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis: a meta-analysis.
|
19720680 |
2009 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stimulation of PBMCs by exogenous leptin significantly increased the production of IL-6 and TNF-alpha in PBMCs from patients with AS in a dose-dependent fashion and these increases were much exacerbated compared to controls.
|
19059800 |
2009 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-B27 subtypes and tumor necrosis factor alpha promoter region polymorphism in Iranian patients with ankylosing spondylitis.
|
19318316 |
2009 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a double-blind, placebo-controlled, phase 1, dose-escalation study, 15 subjects with inflammatory arthritis (14 with rheumatoid arthritis and 1 with ankylosing spondylitis) not receiving tumour necrosis factor alpha (TNFalpha) inhibitors with persistent moderate (grade 2) or severe (grade 3) swelling in a target joint due to inflammatory arthritis received a single intra-articular injection of rAAV2-TNFR:Fc at 1 x 10(10) (n = 5) or 1 x 10(11) (n = 6) DNase resistant particles per ml joint volume or placebo (n = 4) into a knee (n = 14) or ankle (n = 1).
|
18678578 |
2009 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to examine the role of the polymorphisms 36A>G (TNFR1), 676T>G (TNFR2), -857C>T (TNF-alpha), -308G>A (TNF-alpha), and -238G>A (TNF-alpha) in AS susceptibility.
|
19772798 |
2009 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No relationship was found between TNF-alpha promoter 238 polymorphisms and AS in HLA-b27+ population.
|
20535510 |
2010 |