Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Two human hepatoma cell lines (SK-Hep and Hep-G2) displayed a time- and dose-dependent increase in steady state levels of NCF/IL-8 mRNA and secretion of chemotactic activity in response to TNF and IL-1.
|
2156928 |
1990 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Nuclear extracts from LPS, TNF-alpha, and IL-1beta-treated VSMCs, IL-1beta-treated human hepatoma HepG2, and human lung fibroblast IMR-90 cells showed strong inducible binding activity to the NF-kappaB-like site by gel shift assays.
|
9446586 |
1998 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have recently reported that the human hepatoma cell line HepG2 expresses the TNFalpha gene and releases biologically active TNFalpha protein after stimulation with interleukin-1beta (IL-1beta).
|
9594023 |
1998 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because hepatocellular carcinomas (HCCs) are one of the most resistant tumors to systemic chemotherapy, we investigated the activation of NFkappaB and the consequence of its inhibition by an IkappaBalpha-super repressor during tumor necrosis factor alpha (TNFalpha)- and chemotherapy-induced apoptosis in HCC cell lines.
|
11059688 |
2000 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Anti-human hepatocellular carcinoma effects of tumor necrosis factor-related apoptosis-inducing ligand in vitro & in vivo.
|
11749866 |
2001 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We analysed the effect of the human recombinant proinflammatory cytokines interleukin (IL)-6 and IL-1beta, tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human type I 5'-iodothyronine deiodinase (5'DI) enzyme activity in the human hepatocarcinoma cell line HepG2, i.e. in a homologous human system.
|
11916626 |
2002 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To observe the anti-liver cancer activity of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene and its bystander effects on hepatocellular carcinoma (HCC) cell line SMMC7721.
|
14991932 |
2004 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Increased risk of developing hepatocellular carcinoma associated with carriage of the TNF2 allele of the -308 tumor necrosis factor-alpha promoter gene.
|
15280623 |
2004 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Partial contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAIL receptor pathway to antitumor effects of interferon-alpha/5-fluorouracil against Hepatocellular Carcinoma.
|
15585621 |
2004 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human hepatocarcinoma cell line HepG(2), drug resistant hepatocarcinoma cell line HepG(2)/adriamycin (ADM) and hepatocarcinoma cell line transfected with TNF-alpha gene HepG(2)/ADM/TNF were injected into the liver of nude mice via orthotopic implantation and MDR model of liver neoplasm in vivo was established (HepG(2), ADM, TNF, BCT groups).
|
16237754 |
2005 |
Liver carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Hepatic expression of the tumor necrosis factor family member lymphotoxin-beta is regulated by interleukin (IL)-6 and IL-1beta: transcriptional control mechanisms in oval cells and hepatoma cell lines.
|
15910501 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We measured the cytokine levels of Th1 (IL-2 and IL-2R), Th2 (IL-10) and the pro-inflammatory cytokines (IL-6 and IL-6R and TNF and TNF-RI and II) by the ELISA technique in the sera of 33 hepatocellular carcinoma (HCC) patients and 20 chronic liver disease (CLD) patients.
|
16425355 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Telomerase-dependent virotherapy overcomes resistance of hepatocellular carcinomas against chemotherapy and tumor necrosis factor-related apoptosis-inducing ligand by elimination of Mcl-1.
|
16103092 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Fiber-modified adenoviral vector expressing the tumor necrosis factor-related apoptosis-inducing ligand gene from the human telomerase reverse transcriptase promoter induces apoptosis in human hepatocellular carcinoma cells.
|
15849810 |
2005 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The activation of NF-kappaB induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) renders hepatocellular carcinoma (HCC) resistant to TRAIL-mediated cell apoptosis.
|
16627981 |
2006 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hepatocellular carcinoma (HCC) displays a striking resistance to chemotherapeutic drugs or innovative tumor cell apoptosis-inducing agents such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
|
16583461 |
2006 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known to induce cancer cell-specific apoptosis, but hepatoma cells are resistant to TRAIL-induced apoptosis.
|
16820920 |
2006 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to assess the association between tumor necrosis factor (TNF) alpha polymorphism and hepatic fibrosis, and risk for HCC.
|
18030367 |
2007 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population.
|
18070287 |
2007 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population.
|
18070287 |
2007 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Human Hepatocellular carcinoma (HCC) cell types exhibit a major resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell death, and the key determinants of mechanisms accounting for TRAIL susceptibility, still remain controversial.
|
17700059 |
2007 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conducted a case-control study including 209 incident HCC cases and two control groups (275 hospital controls and 381 patients with chronic liver disease [CLD] without HCC) to investigate whether IL-1B and TNF-A gene polymorphisms influence HCC susceptibility with any interaction with alcohol and tobacco.
|
18603357 |
2008 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several genetic alterations were detected in the 44 TNF-TNFR superfamily genes by sequencing hepatocellular carcinoma DNA samples.
|
18243134 |
2008 |
Liver carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that combined treatment with subtoxic doses of quercetin (3',3',4',5,7-pentahydroxyflavone), a flavonoid found in many fruits and vegetables, plus tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces rapid apoptosis in TRAIL-resistant hepatocellular carcinoma (HCC) cells.
|
18980244 |
2008 |
Liver carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We suggested that the presence of the high producer allele -308A in the TNF-alpha gene appears to be associated with an increased risk for the development of HCC in Turkish population.
|
19683483 |
2009 |