TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 GeneticVariation group BEFREE In an analysis of the cases and unmatched controls who did not receive sulfasalazine, an increased risk of PJP was associated with lung disease (3.88, 1.89-7.95) and the use of glucocorticoid (5.71, 2.68-12.19), methotrexate (5.25, 2.01-13.74), and tumor necrosis factor inhibitors (2.32, 1.10-4.93). 30057321 2019
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 GeneticVariation group BEFREE The results confirm the hypothesis that TNF-alpha polymorphisms are associated with asbestos-induced fibrotic or malignant lung diseases in Germans. 20486865 2010
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE Miners were genotyped for common functional polymorphisms in the gene for tumour necrosis factor alpha (TNF) and lymphotoxin alpha (LTA), two proinflammatory cytokines that have been implicated in the pathogenesis of chronic lung diseases. 12566517 2003
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE Assessing the relationship between TGF β 1, IL-8, and TNF- α and lung disease in CF in an exacerbation-free interval. 24062613 2013
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE On the other hand, the triple positive-CD4+ cells (PMA stimulation) alone or together with the mock/MAB ratio of IL-2+/TNF-α+ CD4 cells could predict MAB-LD in the MAB-Co group or the controls. 31085455 2019
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE It may be time to reconsider TNF-α antagonists as potential anti-inflammatory agents for CF lung disease. 22660986 2012
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE We tested 13 polymorphisms in 8 genes that play a key role in the inflammatory response: tumor necrosis factor, lymphotoxin alpha, interleukin (IL) 1B, IL1 receptor antagonist, IL6, IL8, IL10 and transforming growth factor beta 1 (TGFB1), for an association with lung disease progression and nutritional status in 329 CF patients. 19009622 2008
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group RGD Ventilator-induced lung injury leads to loss of alveolar and systemic compartmentalization of tumor necrosis factor-alpha. 11126266 2000
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group CTD_human Before these experiments, there was no information available that would provide a basis for predicting whether or not TGF-beta(1) expression induces fibroproliferative lung disease in fibrogenic-resistant TNF-alphaRKO mice, an increasingly popular animal model. 11472967 2001
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group RGD Evidence of a central role for p38 map kinase induction of tumor necrosis factor alpha in pancreatitis-associated pulmonary injury. 10455887 1999
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE The concentrations of TNF-α and CXCL8, but not others, were negatively correlated with severity of disease (lung function forced expiratory volume in 1 s) (TNF-α vs. total: r = -0.359, P= 0.002 vs. moderate/severe: r= -0.541, P= 0.001; CXCL8 vs. total: r = -0.327, P= 0.006 vs. moderate/severe: r = -0.625, P= 0.0001, respectively). 28836545 2017
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE We recently published a case-control study that evaluated the interaction between silica exposure and minor variants in the genes coding for interleukin-1alpha (IL-1alpha), interleukin-1 receptor antagonist (IL-1RA) and tumor necrosis factor alpha (TNFalpha) as risk factors associated with silicosis, a fibrotic lung disease. 12176706 2002
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE This review summarizes current knowledge on the role of TNFα in pulmonary disease pathologies, with a focus on the therapeutic potential of TNFα-targeting agents in treating inflammatory lung diseases. 28642115 2017
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group RGD [Studies on the expression of mRNA of anti- and pro-inflammatory cytokines in acute lung injury induced by lipopolysaccharide in rat]. 15461830 2004
CUI: C0024115
Disease: Lung diseases
Lung diseases
0.600 Biomarker group BEFREE PM2.5 exposure during pregnancy results in lung inflammation in offspring mediated by increased HMGB1 expression, followed by upregulated IL-1, IL-6 and TNF-α secretions, which may contribute to the development of inflammatory lung diseases in later life. 29233668 2018