TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis. 8741040 1996
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Inhibition of the cytokine tumor necrosis factor alpha (TNFα), originally considered as a mediator in sepsis, has led to frustrating results. 30343600 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumor necrosis factor-alpha (TNF-alpha) is thought to play a major role in systemic inflammation associated with sepsis. 18848768 2009
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE The influence of polymorphisms of the TNF locus on susceptibility to, and outcome from sepsis remains uncertain. 15526005 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE In addition, 20 patients with post-surgical inflammation, 20 patients with sepsis or septic shock were included and TNFα was determined following ex vivo stimulation of whole blood with 500 pg/mL LPS. 28771573 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Because the nuclear factor-κB (NF-κB) coupled pathway is believed to amplify inflammation prevailing in sepsis, the authors tested the hypotheses that the insertion-deletion polymorphism (-94ins/delATTG) (1) alters nuclear translocation of nuclear factor-κB and activator protein-1 (NF-κB1) in monocytes after lipopolysaccharide stimulation; (2) affects lipopolysaccharide-induced NF-κB1 messenger RNA expression, tumor necrosis factor α concentrations, and tissue factor activity; and (3) may be associated with increased 30-day mortality in patients with sepsis. 23249930 2013
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Potential immunologic mechanisms responsible for the rhIL-7 putative beneficial effect were also examined, focusing on IL-17, IL-22, IFN-γ, and TNF-α, cytokines that are critical in the control of sepsis and pulmonary Pseudomonas infections. 27630218 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Macrophages play an important role in the early stage of sepsis as they are tasked with eliminating invading microbes and also attracting other immune cells by the release of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α. 31658116 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE However, the apparent protective effect of the tumor necrosis factor B1B1 genotype on the development of severe encephalopathy may be related to the effects of this genotype on tumor necrosis factor-alpha production in sepsis. 9696492 1998
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Here, we demonstrate that omega-9 treatment is associated with increased levels of the anti-inflammatory cytokine IL-10 and decreased levels of the proinflammatory cytokines TNF-<i>α</i> and IL-1<i>β</i> in peritoneal lavage fluid of mice with sepsis. 30538802 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis. 28840846 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients. 23033000 2013
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE We have previously described a model of chronic alcohol ingestion followed by sepsis from cecal ligation and puncture in which alcohol-fed septic mice have higher mortality than water-fed septic mice, associated with altered gut integrity and increased production of TNF and IFNγ by splenic CD4 T cells without alterations in CD8 T cell function. 29664837 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE The absence of TRPM2 triggered less production of inflammatory mediators (IL-1β, IL-6, TNF-α) and decreased apoptosis related proteins (BNIP3, AIF, Endo G) expressions in response to LPS induced sepsis. 31450153 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE To support the coordination of bioenergetics in human sepsis, we observed elevated NAD(+) levels concomitant with SIRT1 and RelB accumulation at the TNF-α promoter of endotoxin tolerant sepsis blood leukocytes. 21245135 2011
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Thus, our work demonstrates the advantage of genome-scale screening with Cas9 and validates NLRX1 as a potential modulator of TNF-α-induced vascular endothelial apoptosis during sepsis. 30317623 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Change in DNA methylation pattern, histone modification, and microRNA regulation has been shown in sepsis models to silence or activate pro-inflammatory genes such as TNF-α and interleukins, anti-oxidant enzymes, and many signaling pathways. 30179122 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Furthermore, treating mice with a cGMP analog after the induction of sepsis increased TNFR shedding and decreased systemic inflammation. 25628461 2015
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Unbiased hierarchical clustering identified five different clusters of sepsis mediators, including one with markers of platelet activation (e.g., thrombospondin-1) positively associated with platelet count, one with markers of inflammation (e.g., tumor necrosis factor alpha and heat shock protein 70), and endothelial dysfunction (e.g., intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) negatively associated with platelet count, and another involving growth factors of thrombopoiesis (e.g., thrombopoietin), also negatively associated with platelet count. 29028771 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis. 26025100 2015
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE We conducted a systematic review and meta-analysis to determine whether the TNF-alpha -308 A/G polymorphism TNF2 (G/A or A/A) confers susceptibility to sepsis or is associated with increased risk of death from sepsis. 19789454 2010
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE Association between Tumor Necrosis Factor-α Promoter -308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants. 31006736 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction. 16051275 2005