|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of polymorphisms of the TNF locus on susceptibility to, and outcome from sepsis remains uncertain.
|
15526005 |
2004 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we aim to investigate the association of promoter-region polymorphisms IL-6 (-174G/C) rs1800795 and TNF-α (-308G/A) rs1800629 with pneumonia-induced sepsis.
|
26025100 |
2015 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conducted a systematic review and meta-analysis to determine whether the TNF-alpha -308 A/G polymorphism TNF2 (G/A or A/A) confers susceptibility to sepsis or is associated with increased risk of death from sepsis.
|
19789454 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association between Tumor Necrosis Factor-α Promoter -308 G/A Polymorphism and Early Onset Sepsis in Preterm Infants.
|
31006736 |
2019 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction.
|
16051275 |
2005 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found an association between the SNP LTA +252 with the development of sepsis [OR 1.29 (1.00-1.68)]; the SNP IL10 -1082 with sepsis severity [OR 0.53 (0.29-0.97)]; the TNF -308 with mortality [OR 0.33 (0.12-0.95)]; and the IL10 -592 and IL10 -1082 with admission to the intensive care unit (ICU) [OR 3.36 (1.57-7.18)] and [OR 0.18 (0.04-0.86)], respectively.
|
27592234 |
2016 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.
|
20217044 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both rs187084 and rs352162 were significantly associated with TNF-α production by peripheral blood leucocytes in response to bacterial DNA stimulation and a higher sepsis morbidity rate in patients with major trauma.
|
21633947 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the influence of SNPs LTA +252A>G, TNF-863C>A and TNF-308G>A on susceptibility to sepsis, acute respiratory distress syndrome (ARDS), septic shock and sepsis mortality.
|
22507624 |
2012 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped nine polymorphisms in the TNF gene and tested for an association with sepsis syndrome and outcome.
|
18434886 |
2008 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNFA minor A-allele group also had a higher Multiple Organ Failure score of 0.26 (95% CI: 0.03, 0.49; p = 0.024) after adjustment for sex, race, age, and sepsis.
|
23796916 |
2013 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Conclusion</b> We uncovered an association between IL-10 1082 gene variation and sepsis in VLBW infants but did not identify associations between neonatal sepsis and TNF-α 308 or IL-6 gene variation.
|
27960200 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While the genotype TNF-beta1/beta2 has a higher risk for developing complications in general, the TNF-beta2/beta2 genotype is associated with more severe complications and mortality from sepsis.
|
15041959 |
2004 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006).
|
15036247 |
2004 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study investigated the influence of TNF haplotypes on the development of sepsis using the new Sepsis-3 definitions.
|
29274398 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, the relationship between the TNF-alpha 308G/A, the IL-6-174 G/C, the PAI-1, the FVL, the EPCR, and the Cathepsin G (Ars 125 Ser) polymorphisms and the development and outcome of sepsis in pediatric patients was studied.
|
16444434 |
2006 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The -308G >A TNF-α SNP effect was analyzed in the entire patient group, in patients with sepsis (349/520), and in those who developed septic shock (248/520).
|
21670923 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distribution of TNF-α(308) genotypes is associated with outcome, IL-10(1082) with type of microorganism and underlying cause of sepsis, and CD14(159) with type of microorganism.
|
20163933 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the G/A genotype of <i>TNF-α</i> rs1800629 and rs361525 increases sepsis risk in an Asian population.
|
29340067 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both serovars significantly increased the production of cytokines associated with acute sepsis (tumor necrosis factor alpha [TNF-α], interleukin β [IL-β], and IL-6), but temporal differences occurred between these serovars and between different <i>S</i> Choleraesuis strains.
|
30037797 |
2018 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent meta-analysis demonstrated that the tumor necrosis factor-α -308 A allele is associated with higher sepsis risk in adult cohorts.
|
21317641 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients with IL-10 (-1082A/A) genotypes were found significantly higher in post traumatic sepsis patients and had a significantly higher risk to developed sepsis complication (p < 0.05, OR = 0.86, C.I = 0.08-8.8).In case of TNF-α (-308) position, GA and GG genotype patients have a significantly lower risk of poor outcome (p < 0.05, OR = 0.25, C.I = 0.01-1.3) and (p < 0.05, OR = 0.22, C.I = 0.01-0.5) in comparison to AA genotype.
|
26561011 |
2015 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
However, no significant association was found between TNF-α -308G/A and -238G/A polymorphisms and sepsis-related mortality.
|
28294408 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-α variant is closely linked to sepsis syndrome and mortality after severe trauma.
|
26117649 |
2015 |