Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A review of past and future clinical strategies for altering TNF activity during sepsis is also provided.
|
7850574 |
1995 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the pathophysiology of sepsis.
|
8843235 |
1996 |
Septicemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis.
|
8741040 |
1996 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The amount of TNF released in situations of severe infection and sepsis appears to be influenced genetically.
|
8625623 |
1996 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF) is recognized as a central mediator of sepsis, septic shock, and multiple organ failure.
|
8832971 |
1997 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the apparent protective effect of the tumor necrosis factor B1B1 genotype on the development of severe encephalopathy may be related to the effects of this genotype on tumor necrosis factor-alpha production in sepsis.
|
9696492 |
1998 |
Septicemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation.
|
9806674 |
1998 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lipopolysaccharide stimulates the production and the release of numerous endogenous mediators of sepsis: tumor necrosis factor alpha, interleukin-1, and interleukin-6 that induce fever production.
|
10085413 |
1999 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha (TNF-alpha) has well-described effects on lipid metabolism in the context of acute inflammation, as in sepsis.
|
10878750 |
2000 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, in this pilot study the biallelic Ncol polymorphism within the TNF locus was not a prognostic marker for disease progression in high-risk NICU-admitted term and preterm infants with culture-proven sepsis.
|
10782394 |
2000 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This new mechanistic understanding of endothelial regulation and the modulation of tumor necrosis factor-induced endothelial dysfunction creates a novel link between coagulation, inflammation, and cell death and provides insight into the molecular basis for the efficacy of APC in systemic inflammation and sepsis.
|
11278252 |
2001 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lethality from sepsis is believed to be mediated by a proinflammatory cytokine cascade, yet blocking the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) fails to prevent mortality in human disease and a mouse model of sepsis induced by cecal ligation and puncture (CLP).
|
12117955 |
2002 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is a well-documented central inflammatory mediator in sepsis.
|
12906716 |
2003 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A genomic polymorphism within the TNF locus is associated with increased TNF-alpha levels and high mortality in severe trauma and sepsis.
|
14500138 |
2003 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Antibodies to ubiquitin were able to (1) significantly increase (2- to 5-fold) the TNF-alpha response to endotoxin in whole blood from trauma and sepsis patients, (2) completely neutralize the inhibitory effect of trauma patients' serum on healthy donors' TNF-alpha production, and (3) partially neutralize the inhibitory effect of sepsis patients' serum on healthy donors' TNF-alpha production.
|
12406900 |
2003 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of polymorphisms of the TNF locus on susceptibility to, and outcome from sepsis remains uncertain.
|
15526005 |
2004 |
Septicemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis.
|
15489642 |
2004 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We challenged human endothelial cells simultaneously with tumor necrosis factor alpha (TNFalpha) and thrombin because many pathophysiological conditions, such as sepsis, diabetes, and coronary artery disease, result in the concurrent presence of circulating inflammatory mediators and activated thrombin.
|
15201277 |
2004 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
While the genotype TNF-beta1/beta2 has a higher risk for developing complications in general, the TNF-beta2/beta2 genotype is associated with more severe complications and mortality from sepsis.
|
15041959 |
2004 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006).
|
15036247 |
2004 |
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha as a central mediator of the inflammation cascade is correlated to sepsis outcome.
|
15187748 |
2004 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor alpha -- 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants.
|
15131465 |
2004 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction.
|
16051275 |
2005 |
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our findings suggest that TNF-alpha-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis.
|
15650061 |
2005 |
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |