TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE A review of past and future clinical strategies for altering TNF activity during sepsis is also provided. 7850574 1995
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the pathophysiology of sepsis. 8843235 1996
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Pentoxifylline reduces plasma tumour necrosis factor-alpha concentration in premature infants with sepsis. 8741040 1996
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE The amount of TNF released in situations of severe infection and sepsis appears to be influenced genetically. 8625623 1996
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumor necrosis factor (TNF) is recognized as a central mediator of sepsis, septic shock, and multiple organ failure. 8832971 1997
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE However, the apparent protective effect of the tumor necrosis factor B1B1 genotype on the development of severe encephalopathy may be related to the effects of this genotype on tumor necrosis factor-alpha production in sepsis. 9696492 1998
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Lipopolysaccharide stimulates the production and the release of numerous endogenous mediators of sepsis: tumor necrosis factor alpha, interleukin-1, and interleukin-6 that induce fever production. 10085413 1999
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumor necrosis factor alpha (TNF-alpha) has well-described effects on lipid metabolism in the context of acute inflammation, as in sepsis. 10878750 2000
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE In conclusion, in this pilot study the biallelic Ncol polymorphism within the TNF locus was not a prognostic marker for disease progression in high-risk NICU-admitted term and preterm infants with culture-proven sepsis. 10782394 2000
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE This new mechanistic understanding of endothelial regulation and the modulation of tumor necrosis factor-induced endothelial dysfunction creates a novel link between coagulation, inflammation, and cell death and provides insight into the molecular basis for the efficacy of APC in systemic inflammation and sepsis. 11278252 2001
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Lethality from sepsis is believed to be mediated by a proinflammatory cytokine cascade, yet blocking the proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and interleukin-1 (IL-1) fails to prevent mortality in human disease and a mouse model of sepsis induced by cecal ligation and puncture (CLP). 12117955 2002
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumor necrosis factor-alpha (TNF-alpha) is a well-documented central inflammatory mediator in sepsis. 12906716 2003
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE A genomic polymorphism within the TNF locus is associated with increased TNF-alpha levels and high mortality in severe trauma and sepsis. 14500138 2003
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Antibodies to ubiquitin were able to (1) significantly increase (2- to 5-fold) the TNF-alpha response to endotoxin in whole blood from trauma and sepsis patients, (2) completely neutralize the inhibitory effect of trauma patients' serum on healthy donors' TNF-alpha production, and (3) partially neutralize the inhibitory effect of sepsis patients' serum on healthy donors' TNF-alpha production. 12406900 2003
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE The influence of polymorphisms of the TNF locus on susceptibility to, and outcome from sepsis remains uncertain. 15526005 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis. 15489642 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE We challenged human endothelial cells simultaneously with tumor necrosis factor alpha (TNFalpha) and thrombin because many pathophysiological conditions, such as sepsis, diabetes, and coronary artery disease, result in the concurrent presence of circulating inflammatory mediators and activated thrombin. 15201277 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE While the genotype TNF-beta1/beta2 has a higher risk for developing complications in general, the TNF-beta2/beta2 genotype is associated with more severe complications and mortality from sepsis. 15041959 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE Considering combinations of genotypes, the TNF-alpha high and IL-10 low producer genotype combination was associated with a approximately 6-fold increased risk of death compared to the TNF-alpha-low and IL-10 intermediate/high producer genotype combination, after adjustment for either APACHE II (P=0.004), MOF score (P=0.004) or sepsis (P=0.006). 15036247 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Tumor necrosis factor alpha as a central mediator of the inflammation cascade is correlated to sepsis outcome. 15187748 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE Tumor necrosis factor alpha -- 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants. 15131465 2004
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE In conclusion, this study may indicate that TNF-alpha-308G/A and IL-10-592C/A polymorphisms involved in subsequent activation of cytokine network had a larger effect on clinical outcome in patients with sepsis than TLR4Asp299Gly, Thr399Ile, and CD14-159C/T polymorphisms associated with the initial host-microbial interaction. 16051275 2005
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Our findings suggest that TNF-alpha-mediated up-regulation of PDE2 may destabilize endothelial barrier function in sepsis. 15650061 2005
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis. 16859504 2006