Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 AlteredExpression disease BEFREE Head to head comparison of two commercial fecal calprotectin kits as predictor of Mayo endoscopic sub-score and mucosal TNF expression in ulcerative colitis. 31790426 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE To date, responsiveness to tumor necrosis factor alpha inhibitors in ulcerative colitis (UC) patients is not predictable. 31782956 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE The cytokine TNF is thought to play a major role in the immunopathogenesis of ulcerative colitis, and anti-TNF antibodies are considered as cornerstones of clinical therapy. 31747580 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 AlteredExpression disease BEFREE This is the first time that the effect of original CS against UC in mice has been reported and it is through promoting dominant intestinal microflora such as <i>Blautia</i>, mitigating intestinal microflora dysbiosis, and regulating the expressions of TNF-α, claudin-1, occludin, and ZO-1. 31731793 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE The activation of A3AR by 2-Cl-IB-MECA significantly decreased TNF-α and IL-1β production and attenuated the NF-κB p65 activation in colonic tissues from patients with UC. 31714673 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE Rates of anti-TNF therapy during emergency admission for UC have increased whereas overall colectomy rates have fallen. 31714573 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 AlteredExpression disease BEFREE S. boulardii treatment reduced AOM/DSS-induced UC carcinogenesis in mice, as indicated by the reduced tumor load and reduced TNF-α and IL-6 levels in vivo, as well its effects on TNF-α and IL-6 activities in vitro. 31694526 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE The Ulcerative Colitis Response Index for Detection of Mucosal Healing in Patients Treated With Anti-tumour Necrosis Factor. 31628842 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE The long-term effects of anti-TNFα therapy in ulcerative colitis are debatable. 31579961 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE Searching terms were ('infliximab', OR 'anti-tumor necrosis factor', OR 'tumor necrosis factor', OR 'tumor necrosis factor alpha antibody', OR 'tumor necrosis factor antibody', OR 'IFX') and ('ulcerative colitis' OR 'UC'). 31562896 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE The present study aimed to develop a tumor necrosis factor‑α (TNF‑α) B‑cell epitope/IL‑1β helper T lymphocyte epitope complex MAP vaccine for the alleviation of ulcerative colitis (UC) in mice. 31524230 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE Here, a TMDD model is proposed to describe the interaction between infliximab and TNF in UC patients. 31489538 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE To examine whether there is an increased risk of developing Crohn's disease (CD) and ulcerative colitis (UC) while under treatment with anti-TNFα agents for diseases other than inflammatory bowel disease (IBD) METHODS: A nationwide cohort study, based on Danish health registries, of all patients who utilised anti-TNFα agents for non-IBD indications. 31267570 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE Treatment with tumor necrosis factor antagonists increased steadily for patients with CD (43.4% of all patients in Brazil were treated in 2014) but less so for patients with UC (4.5% of all patients were treated in 2014).Surgery for IBD decreased with time. 31252191 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE <i>In vitro</i>, we adopted the bone marrow-derived macrophages (BMDMs) as well as BMDMs co-cultured with Caco2 cells to verify the underlying mechanisms and effects of JPQC on UC under TNF-α stimulation. 31210713 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 AlteredExpression disease BEFREE Finally, colonic IL-8+ T cells co-expressed GM-CSF, TNF- and IL-6 were detected ex vivo and, promoted by IL-12 in the mucosa and mLNs in UC only. 31206576 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 GeneticVariation disease BEFREE We aimed to investigate the impact of the single nucleotide polymorphisms of rs34436714 of the NOD-like receptor protein 12 gene on the production of tumor necrosis factor-alpha (TNFα) in patients with inflammatory bowel disease (IBD)In a matched case-control study 90 patients with IBD, 56 with Crohn disease (CD) and 34 with ulcerative colitis, were genotyped and compared to 98 healthy comparators matched for age and gender. 31169706 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE Baicalin significantly increased the activity of SOD, CAT and GSH-Px in colon tissue of rats with UC, but significantly decreased the content of MDA, IL-1β, MPO, PEG2 and TNF-α in colon tissue of rats with UC. 31103874 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE A rat UC model was induced with trinitro-benzene-sulfonic acid (TNBS), concentrations of the cytokines IL-1α, IL-6, IL-8, IL-1β, and TNF-α were significantly up-regulated and the concentrations of IL-4, IL-10, and IL-13 were significantly down-regulated compared with the control group (P < 0.05). 31102937 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE The non-persistence rate of anti-TNFα therapy was 72.6% and 80.4% in the UC and CD groups, respectively, with discontinuation of medication being the most common reason in both the UC and CD groups (63.9% and 73.3%, respectively). 31098835 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE BT-11 significantly decreases interferon gamma positive (IFNγ+) and tumor necrosis factor alpha positive (TNFα+) cluster of differentiation 4 positive (CD4+) T cells and increases forkhead box P3 positive (FOXP3+) CD4+ T cells in colonic lamina propria mononuclear cells from patients with CD and patients with UC at concentrations of 0.01 µM when treated ex vivo. 31077582 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE <b>Aims:</b> To evaluate the cost differences between a treatment strategy including tofacitinib (TOFA) vs treatment strategies including adalimumab (ADA), golimumab (GOL), infliximab (IFX), and vedolizumab (VEDO) among all patients with moderate-to-severe ulcerative colitis (UC) (further stratified by patients naïve/exposed to tumor necrosis factor inhibitors [TNFis]). 31012362 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 Biomarker disease BEFREE We further demonstrated that GSK2256294, a clinical EPHX2i, reduced the production of IL2, IL12p70, IL10 and TNFα in both ulcerative colitis and Crohn's disease patient-derived explant cultures. 31002701 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 AlteredExpression disease BEFREE Compared with that in the DSS group, FMT ameliorated the severity of inflammation due to ulcerative colitis in mice, which was accompanied by a significantly decreased MPO activity, reduced levels of TNF-α and IL-1β, and an increased level of IL-10 in colon tissue (all P<0.05). 30906449 2019
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis
0.600 AlteredExpression disease BEFREE The levels of IL-6 and TNF-α in peripheral blood in the UC patient group were significantly increased compared with those in the healthy adult group (P<0.01), while the levels of IL-10 and IL-4 in peripheral blood were significantly decreased compared with those in the healthy adult group (P<0.01). 30906432 2019