|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Some studies have reported that proinflammatory polymorphisms in tumor necrosis factor-alpha-308 (TNF-alpha-308) gene promoter (substitution G-->A, designated as TNF1 and TNF2) is associated with increased UC risk.
|
18827481 |
2008 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study suggests that one of the genes responsible for UC may be the TNF gene, or an adjacent gene, and that TNFRSF1B gene polymorphisms contribute greatly to the increased onset risk of CD and to the disease behavior.
|
11904678 |
2002 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To describe the prevalence of serological markers in newly diagnosed treatment-naïve pediatric inflammatory bowel disease (IBD), their utility in differentiating Crohn's disease (CD), ulcerative colitis (UC) and symptomatic non-IBD patients and whether serological markers are associated with early TNF blocker treatment.
|
27887202 |
2017 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
CD and UC showed highly significant difference in the allelic distribution of TNF-α G-308A, where the A allele was found to be related to CD, and the G allele to UC.
|
26316104 |
2015 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The TNF-2 and LT alpha-2 haplotypes were associated with higher TNF alpha production in CD patients, and the TNF-4 haplotype was associated with lower TNF alpha production in UC patients.
|
11196710 |
2000 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We aimed to investigate the impact of the single nucleotide polymorphisms of rs34436714 of the NOD-like receptor protein 12 gene on the production of tumor necrosis factor-alpha (TNFα) in patients with inflammatory bowel disease (IBD)In a matched case-control study 90 patients with IBD, 56 with Crohn disease (CD) and 34 with ulcerative colitis, were genotyped and compared to 98 healthy comparators matched for age and gender.
|
31169706 |
2019 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To determine potential associations of interleukin-1 receptor antagonist (IL-1ra), tumour necrosis factor alpha (TNF alpha), and tumour necrosis factor beta (TNF beta) gene polymorphisms with ulcerative colitis or subsets of ulcerative colitis in a Spanish population.
|
10321759 |
1999 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We investigate the association between TNF promoter polymorphisms and susceptibility to ulcerative colitis (UC) in the Chinese Han ethnic population.
|
16863613 |
2006 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor (TNF) superfamily gene-15 (SF15) polymorphisms were associated with CD (OR 2.68; 95% CI 1.86-3.86), while TNF-308 polymorphisms (OR 1.82; 95% CI 1.15-2.9), cytotoxic T lymphocyte antigen (CTLA)-4 (OR 2.75; 95% CI 1.22-6.22) and MICA allele (OR 2.41; 95% CI 1.89-3.07) were associated with ulcerative colitis in Asians.
|
21887729 |
2012 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Combination therapy was not superior in any of the registration trials for Crohn's disease and ulcerative colitis for TNF antagonists, vedolizumab, or ustekinumab.
|
29462391 |
2018 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Based on the results of the pivotal clinical GEMINI trials, vedolizumab was approved for the treatment of adult patients with moderately to severely active ulcerative colitis (UC) and Crohn's disease (CD) refractory or intolerant to either conventional therapy or TNFα inhibitors.
|
29930467 |
2018 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Ten candidate SNPs, multidrug resistance 1 (MDR1) 3435 (C>T), regulated upon activation, normal T-cell expressed and secreted (RANTES)-28 (C>G), heat-shock protein (HSP)70-2 1267 (B>A), NADPH oxidase p22PHOX 242 (C>T), Toll-like receptor (TLR)2-196 to -174 (ins >del), CD14-159 (C>T), Mannan-binding lectin (MBL)2 codon 54 (G>A), tumor necrosis factor-α(TNF-α) -857 (C>T), interleukin-1β(IL-1β)-511 (C>T), and IL-1β -31 (T>C) were genotyped in 58 UC patients without neoplastic lesions, in relation to CIHM in the rectal mucosa of three candidate CpG (p14, p16 and E-cadherin: CDH1) loci, assessed by methylation-specific-polymerase chain reaction (MSP).
|
21498716 |
2011 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In UC the AA and GA genotype was associated with increased use of azathioprine and anti-TNF antibodies, but significantly less patients with the PTPN22 variant featured malabsorption syndrome (p = 0.026).
|
27467733 |
2016 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn's disease and ulcerative colitis.
|
22960943 |
2013 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variation was observed between the ulcerative colitis study group and the control population for the TNF-alpha-308 polymorphism (p= 0.0135).
|
15223609 |
2004 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Protective association of tumor necrosis factor superfamily 15 (TNFSF15) polymorphic haplotype with Ulcerative Colitis and Crohn's disease in an Indian population.
|
25501099 |
2014 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To describe the use of tumor necrosis factor-alpha inhibitors (TNFis) among pregnancies ending in a live birth and with a diagnosis of ankylosing spondylitis (AS), Crohn's disease (CD), juvenile idiopathic arthritis (JIA), psoriasis (PsO), psoriatic arthritis (PsA), rheumatoid arthritis (RA), or ulcerative colitis (UC).
|
30430682 |
2019 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Reporter gene assays with a construct comprising a luciferase gene driven by the TNF-alpha promoter revealed that isolates from Crohn's disease patients induced a stronger activation of the TNF-alpha gene than isolates from ulcerative colitis patients.
|
15103488 |
2004 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Tumour necrosis factor-alpha (TNF-α) (-308G/A) is associated with UC onset, suggesting that the presence of -308A allele could confer a relative risk of 3.62 more to develop UC in general population.
|
27528546 |
2016 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
119 healthy, unrelated controls, 95 patients with Crohn's disease and 93 patients with ulcerative colitis were genotyped for the (G to A) -308 TNF-alpha promoter polymorphism on chromosome 6, the codon 497 EGFR polymorphism on chromosome 7 and the TaqI polymorphism of the VDR gene on chromosome 12.
|
12428072 |
2002 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
This study suggests that one of the genes responsible for UC may be the TNF gene, or an adjacent gene, and that TNFRSF1B gene polymorphisms contribute greatly to the increased onset risk of CD and to the disease behavior.
|
11904678 |
2002 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Carrier frequency of TNF-857T between CD and controls (36% vs. 40%; P = 0.556; OR: 1.18, 95% CI 0.74-1.88), or between UC and controls (41% vs. 37%; P = 0.743; OR: 0.85, 95% CI 0.45-1.62) did not differ significantly.
|
16611251 |
2006 |
|
Ulcerative Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors).
|
28505128 |
2017 |