TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Tumor necrosis factor-alpha (TNF-alpha) is a multifunctional cytokine that has been detected in several human cardiac-related conditions, including congestive heart failure and septic cardiomyopathy. 9577949 1998
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group CTD_human Peripartum cardiomyopathy: analysis of clinical outcome, left ventricular function, plasma levels of cytokines and Fas/APO-1. 10716473 2000
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 AlteredExpression group BEFREE Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression. 10953034 2000
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Proinflammatory cytokines, including tumor necrosis factor (TNF)alpha, have been recognized as important physiopathogenetic factors in the initiation and continuation of inflammatory cardiomyopathies. 15218506 2004
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 GeneticVariation group BEFREE We describe a 9-year-old African American boy with the P46L mutation of the TNF receptor who presented with 2 previously unrecognized manifestations: sacroiliitis and myocardiopathy, both showing a reversible course. 15630744 2005
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 GeneticVariation group BEFREE TNF gene polymorphisms are associated with reduced survival in severe Chagas' disease cardiomyopathy patients. 16427798 2006
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-alpha transgenic mice. 17038643 2006
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 GeneticVariation group BEFREE These results indicate that TNF polymorphisms are associated neither to CCC development nor to progression to more severe forms of cardiomyopathy in Brazilian Chagas disease patients. 17141882 2007
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE This biological framework, which is also involved in progression of cardiomyopathy in humans, is more pronounced in HIV-infected patients, in whom proinflammatory cytokines TNF-alpha, IL-1 and IL-6 are increased, resulting in an enhanced expression of cardiac iNOS, especially in patients with a low CD4 T cell count. 17336407 2007
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Tumor necrosis factor (TNF) is an inflammatory cytokine that is upregulated in a number of cardiomyopathies. 20007453 2010
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Therapeutic group RGD Antioxidants and tumor necrosis factor alpha-inhibiting activity of sesame oil against doxorubicin-induced cardiotoxicity. 24441175 2014
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Here, particular attention has been paid to tumor necrosis factor alpha (TNF) and transforming growth factor beta (TGF-β) although other cytokines may be involved in the chagasic cardiomyopathy. 27622432 2017
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE The effect of 28 days of celecoxib (100 mg/kg/day) and its combination with folic acid (10 mg/kg/day) was studied on doxorubicin-induced cardiomyopathy according to serum lactate dehydrogenase (LDH), creatine kinase (CK-MB), troponin-T (Tn-T), tumor necrosis factor alpha (TNF-α), cardiac thiobarbituric acid reactive substance (TBARS), and glutathione (GSH) levels as well as systolic blood pressure (SBP), heart rate (HR) and ultrastructural studies. 28274156 2017
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 GeneticVariation group BEFREE Bones, tumors, and cardiomyopathy are examples of niches and conditions that contain MSCs and are enriched with tumor necrosis factor α (TNFα) and transforming growth factor β1 (TGFβ1). 28553282 2017
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE In this review, we explore the emerging role of tumor necrosis factor receptor-associated factor 6 (TRAF6)-nuclear factor kappa B (NF-κB) signaling axis in atherosclerosis, ischemic heart disease, pathologic cardiac hypertrophy or heart failure, myocarditis, and sepsis-induced cardiomyopathy. 29175266 2018
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Several cytokines including TNF-α, TGF-β, and different interleukins such as IL-1 IL-4, IL-6, IL-8, and IL-18 are involved in the development of various inflammatory cardiac pathologies, namely ischemic heart disease, myocardial infarction, heart failure, and cardiomyopathies. 29862462 2018
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 GeneticVariation group BEFREE Several features were evaluated, including the characterization of T. cruzi directly from the blood of patients, host polymorphisms of genes related to cardiomyopathy (TNF, WISP1, CCR5, and TGF-β1) and clinical aspects of the patients. 29922960 2018
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.600 Biomarker group BEFREE Thereby, the goal of our current work is to figure out the functional role of mitochondrial fragmentation in TNF-α-induced septic cardiomyopathy. 30740674 2019