|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No evidence of significant effect of TNF-αG-308A polymorphism on body mass index (BMI) or obesity risk was detected (BMI: WMDRE = 0.05, 95%CI: -0.62 to 0.73; risk of obesity: ORFE = 1.09, 95%CI: 0.87 to 1.35).
|
25729992 |
2015 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene.
|
10885566 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, comparing cases-subgroups in terms of the age of onset of the disease, consanguinity, family history, obesity and acne severity; no statistical significance was observed regarding frequencies of genotypic variants related to the both TNF-α -308 and IL-10 -1082 polymorphisms (>0.05).
|
22835835 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study the relationship between TNF-α promoter gene polymorphism and obesity in an Iranian population has been studied.
|
21559831 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The main objective of this study was to analyze the pathogenic role of the tumor necrosis factor alpha (TNF-alpha) system in the development of nonalcoholic steatohepatitis (NASH).Fifty-two obese patients were studied.
|
11732005 |
2001 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this cross-sectional study (n = 498; 258 males, 240 females), association of genotypes (PCR–RFLP) of 11-βHSD1 and TNF-α were analyzed with obesity [BMI ≥ 25 kg/m(2), percentage body fat (%BF by DEXA); subcutaneous and intra-abdominal fat area (L(2-3) level by single slice MRI) in a sub sample] and insulin resistance.
|
24078163 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TNF-α and PON promoter methylation levels could be involved in the susceptibility to stroke and obesity outcome, respectively.
|
24500802 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPARγ), and insulin receptor substrate-1 (IRS-1) are associated with obesity, insulin resistance, and inflammation.
|
29256014 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNFA -308 G/A polymorphism modified the relationship between dietary fat intake, obesity risk, and serum lipid concentrations in black SA women.
|
20335630 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies in Caucasian subjects have suggested that the G-308A transition in the 5' region of the TNF-alpha gene may be associated with insulin resistance and obesity.
|
10954020 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, TNF-α-308G/A and the GNB3 C825T polymorphisms are associated with obesity and AMI in the Taiwanese population.
|
22408428 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present results suggest that the TNF alpha/G-308A polymorphism might interact with other susceptibility factors to coronary heart disease to predispose to insulin resistance, and that the ability of TNF-alpha to induce insulin resistance may extend beyond obesity.
|
11888514 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ME attenuated the influence of APOB rs512535 and TNFA rs361525 on obesity risk in FMP.WC was significantly associated to GRS.
|
28294290 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Background The objective of this study was to investigate the association of polymorphisms in four genes, tumor necrosis factor-α (TNFA), patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin (ADIPOQ) and apolipoprotein C3 (APOC3), with obesity and non-alcoholic fatty liver disease (NAFLD) in Asian Indian adolescents.
|
31216264 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The effect of the -308A allele of the TNF-alpha gene on insulin action is dependent on obesity.
|
12855762 |
2003 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These exploratory results require replication but provide evidence that autoimmune conditions, late birth order, and obesity act partly through a common inflammatory pathway, posing a greater risk to individuals with variant TNF and IL10 genotypes than those with wild-type alleles.
|
17510437 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found a relation between G174C polymorphism in IL-6 gene and G308A in TNF-alpha gene with the occurrence of obesity.
|
20156727 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that polymorphisms of the TNF-alpha gene are unlikely to contribute to CHD risk in an important way, but the TNF-alpha/-308 polymorphism should be investigated further in relation to obesity.
|
9502188 |
1998 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The tumour necrosis factor (TNF)2 allele appears to be linked with increased insulin resistance and obesity, conditions often found in overweight patients with polycystic ovary syndrome (PCOS).
|
10050654 |
1999 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of linkage and association analyses suggest that in hypertensive pedigrees of French-Canadian origin, the TNF-alpha gene locus contributes to the determination of obesity and obesity-associated hypertension.
|
10904006 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to study the role of TNF-α in the pathogenesis of IR and Ob in PCOS, as well as a C850T (rs1799724) polymorphism in the promoter region of the TNF-α gene, in a group of 204 PCOS patients and 204 age-matched healthy controls.
|
25083576 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Recently we analyzed the -308 TNFalpha polymorphism and that of HSP70-2 gene in Tunisian patients with obesity and no significant difference in allele frequencies of the -308 TNFalpha polymorphism was found between obese patients and controls.
|
15223990 |
2004 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study was conducted in order to (i) characterize the adherence to the Mediterranean diet (MD) pattern and fatty acids (FAs) intakes and (ii) explore interactions between TNFA -308 G>A polymorphism and adherence to MD and FAs intakes, respectively, on overweight/obesity risk.
|
25028665 |
2014 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> In 62 overweight/obese adults (BMI ≥ 25 kg/m<sup>2</sup>; 23F/39M), we collected data on: self-reported back pain; anthropometry [BMI, waist circumference, body composition (dual energy X-ray absorptiometry-DEXA)]; metabolic parameters [fasting glucose; insulin sensitivity (hyperinsulinaemic-euglycaemic clamps)]; cardiovascular parameters (blood pressure, lipids); serum inflammation markers [high-sensitivity C-reactive protein (hsCRP; immunoturbidimetric-assay), tumor necrosis factor-<i>alpha</i> (TNF-α), interleukin (IL)-6, and IL-10 (multiplex-assay)]; and adipokines [leptin, adipsin, resistin, and adiponectin (multiplex-assay)].
|
29483883 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No differences were observed in allele and genotype frequencies between obese and non-obese women, and no association of TNFalpha polymorphism with BMI was observed for genotype in the obese women.
|
15650331 |
2004 |