Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
in this clinical study, correlations were studied between plasma levels of circulating TNF-alpha protein (ELISA), its mRNA expression in monocytes (RT-PCR) and genetic variants of TNF-alpha gene (SSCP), with several diseases, including obesity, atherosclerosis, diabetes mellitus, hypertension, as well as risk factors such as age, gender, inflammatory markers, the coagulationfibrinolysis balance, and lipid metabolism.
|
15319168 |
2005 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our aim was to compare lipid, glucose-insulin and inflammatory (tumor necrosis factor alpha; TNF-α) profiles, muscle function, energy expenditure and aerobic capacity between healthy normal-weight (NW) adults, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) adults; to study the associations between these outcomes and the cytokines MSTN, ADP, LP; and to establish cutoffs for MSTN and LP/ADP to identify the MUHO phenotype.
|
29246653 |
2018 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, a decreased processing rate of mTNF-alpha in mature adipocytes combined with an increase in TNF-alpha production may be a potential mechanism resulting in elevated membrane-associated TNF-alpha in adipose tissue in obesity.
|
12031976 |
2002 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No evidence of significant effect of TNF-αG-308A polymorphism on body mass index (BMI) or obesity risk was detected (BMI: WMDRE = 0.05, 95%CI: -0.62 to 0.73; risk of obesity: ORFE = 1.09, 95%CI: 0.87 to 1.35).
|
25729992 |
2015 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls.
|
30350467 |
2019 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene.
|
10885566 |
2000 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Proinflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of tumor necrosis factor-α via sustained activation of p38 mitogen-activated protein kinase.
|
30264458 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and obesity-associated type 2 diabetes, as well as the potential role of ghrelin in the control of apoptosis and autophagy in human adipocytes.
|
22869322 |
2012 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
On the other hand, comparing cases-subgroups in terms of the age of onset of the disease, consanguinity, family history, obesity and acne severity; no statistical significance was observed regarding frequencies of genotypic variants related to the both TNF-α -308 and IL-10 -1082 polymorphisms (>0.05).
|
22835835 |
2012 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We further assessed the contribution of the chronic inflammatory environment in obese adipose tissue to the dysregulated miRNA expression by tumor necrosis factor (TNF)-alpha treatment of adipocytes.
|
19188425 |
2009 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Accordingly, TNF α has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance.
|
24139907 |
2013 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α) levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase.
|
28430139 |
2017 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The increased levels of adipokines such as Leptin, IL-6 and TNF-α and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects.
|
30904536 |
2019 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study the relationship between TNF-α promoter gene polymorphism and obesity in an Iranian population has been studied.
|
21559831 |
2012 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity is associated with the changes of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNFalpha) and transforming growth factor beta (TGFbeta) levels.
|
18278185 |
2008 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha is a candidate gene for the development of both obesity and insulin resistance.
|
12006640 |
2002 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1.
|
31198543 |
2019 |
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The main objective of this study was to analyze the pathogenic role of the tumor necrosis factor alpha (TNF-alpha) system in the development of nonalcoholic steatohepatitis (NASH).Fifty-two obese patients were studied.
|
11732005 |
2001 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, IR(Deltamyel)-mice exhibit decreased concentrations of circulating tumor necrosis factor (TNF) alpha and thus reduced c-Jun N-terminal kinase (JNK) activity in skeletal muscle upon high fat feeding, reflecting a dramatic reduction of the chronic and systemic low-grade inflammatory state associated with obesity.
|
20463885 |
2010 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In general terms, levels of IL-1<i>β</i>, IL-6, IL-8, and tumor necrosis factor-<i>α</i> were higher in Ob people when compared to H controls.
|
28243360 |
2017 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of berberine on obesity and insulin resistance by examining the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/tumor necrosis factor (TNF)-α signaling pathway in livers of HFD-fed obese rats.
|
29365334 |
2018 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, serum TNF-α levels were significantly elevated (P=0.017) and adiponectin levels reduced (total: P=0.0001; high: P=0.022) with obesity.
|
22309242 |
2012 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF α, pro-inflammatory cytokine is associated with obesity, insulin resistance and hyperandrogenism, therefore in present study we tried to find the association between TNF α promoter polymorphisms, TNF α levels and the risk of PCOS.
|
30442458 |
2019 |
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, we specifically examined the role of tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine associated with obesity and a possible modulator of the Wnt pathway.
|
28402277 |
2017 |
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
EST is expressed in abdominal sc adipose tissue of both obese males and females in association with expression of TNF-α and SOCS3, suggesting potential roles in inflammation.
|
21543429 |
2011 |