TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE in this clinical study, correlations were studied between plasma levels of circulating TNF-alpha protein (ELISA), its mRNA expression in monocytes (RT-PCR) and genetic variants of TNF-alpha gene (SSCP), with several diseases, including obesity, atherosclerosis, diabetes mellitus, hypertension, as well as risk factors such as age, gender, inflammatory markers, the coagulationfibrinolysis balance, and lipid metabolism. 15319168 2005
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Our aim was to compare lipid, glucose-insulin and inflammatory (tumor necrosis factor alpha; TNF-α) profiles, muscle function, energy expenditure and aerobic capacity between healthy normal-weight (NW) adults, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) adults; to study the associations between these outcomes and the cytokines MSTN, ADP, LP; and to establish cutoffs for MSTN and LP/ADP to identify the MUHO phenotype. 29246653 2018
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Thus, a decreased processing rate of mTNF-alpha in mature adipocytes combined with an increase in TNF-alpha production may be a potential mechanism resulting in elevated membrane-associated TNF-alpha in adipose tissue in obesity. 12031976 2002
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE No evidence of significant effect of TNF-αG-308A polymorphism on body mass index (BMI) or obesity risk was detected (BMI: WMDRE = 0.05, 95%CI: -0.62 to 0.73; risk of obesity: ORFE = 1.09, 95%CI: 0.87 to 1.35). 25729992 2015
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls. 30350467 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene. 10885566 2000
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Proinflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of tumor necrosis factor-α via sustained activation of p38 mitogen-activated protein kinase. 30264458 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and obesity-associated type 2 diabetes, as well as the potential role of ghrelin in the control of apoptosis and autophagy in human adipocytes. 22869322 2012
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE On the other hand, comparing cases-subgroups in terms of the age of onset of the disease, consanguinity, family history, obesity and acne severity; no statistical significance was observed regarding frequencies of genotypic variants related to the both TNF-α -308 and IL-10 -1082 polymorphisms (>0.05). 22835835 2012
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE We further assessed the contribution of the chronic inflammatory environment in obese adipose tissue to the dysregulated miRNA expression by tumor necrosis factor (TNF)-alpha treatment of adipocytes. 19188425 2009
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Accordingly, TNF α has been implicated in a wide range of autoimmune and infectious diseases, but also in conditions such as obesity and insulin resistance. 24139907 2013
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α) levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase. 28430139 2017
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE The increased levels of adipokines such as Leptin, IL-6 and TNF-α and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects. 30904536 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE In this study the relationship between TNF-α promoter gene polymorphism and obesity in an Iranian population has been studied. 21559831 2012
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obesity is associated with the changes of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNFalpha) and transforming growth factor beta (TGFbeta) levels. 18278185 2008
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumor necrosis factor (TNF)-alpha is a candidate gene for the development of both obesity and insulin resistance. 12006640 2002
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1. 31198543 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE The main objective of this study was to analyze the pathogenic role of the tumor necrosis factor alpha (TNF-alpha) system in the development of nonalcoholic steatohepatitis (NASH).Fifty-two obese patients were studied. 11732005 2001
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Furthermore, IR(Deltamyel)-mice exhibit decreased concentrations of circulating tumor necrosis factor (TNF) alpha and thus reduced c-Jun N-terminal kinase (JNK) activity in skeletal muscle upon high fat feeding, reflecting a dramatic reduction of the chronic and systemic low-grade inflammatory state associated with obesity. 20463885 2010
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE In general terms, levels of IL-1<i>β</i>, IL-6, IL-8, and tumor necrosis factor-<i>α</i> were higher in Ob people when compared to H controls. 28243360 2017
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE We investigated the effects of berberine on obesity and insulin resistance by examining the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/tumor necrosis factor (TNF)-α signaling pathway in livers of HFD-fed obese rats. 29365334 2018
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Additionally, serum TNF-α levels were significantly elevated (P=0.017) and adiponectin levels reduced (total: P=0.0001; high: P=0.022) with obesity. 22309242 2012
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE TNF α, pro-inflammatory cytokine is associated with obesity, insulin resistance and hyperandrogenism, therefore in present study we tried to find the association between TNF α promoter polymorphisms, TNF α levels and the risk of PCOS. 30442458 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Moreover, we specifically examined the role of tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine associated with obesity and a possible modulator of the Wnt pathway. 28402277 2017
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE EST is expressed in abdominal sc adipose tissue of both obese males and females in association with expression of TNF-α and SOCS3, suggesting potential roles in inflammation. 21543429 2011