|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that the linkage of TNF-alpha to obesity might be due to a sequence variant undetected in TNF-alpha or due to a variant in some other closely linked gene.
|
7615786 |
1995 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increased production of TNF by adipocytes, however, may contribute to insulin resistance in obesity and in non-insulin-dependent diabetes mellitus (NIDDM).
|
8899294 |
1996 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using both parametric and nonparametric methods, we found no evidence of linkage of obesity to any of nine candidate genes/regions, including the Prader-Willi chromosomal region (PWS), the human homologue of the mouse agouti gene (ASP), and the genes for leptin (OB), the leptin receptor (OBR/DB), the beta3-adrenergic receptor (ADRB3), lipoprotein lipase (LPL), hepatic lipase (LIPC), glycogen synthase (GYS), and tumor necrosis factor alpha (TNFA).
|
9326333 |
1997 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha), acting as a modulator of gene expression in adipocytes, is implicated in the development of insulin resistance and obesity.
|
9287048 |
1997 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, TNF may function to make the subject less obese by inhibiting LPL and rendering the animal more insulin resistant.
|
9278582 |
1997 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several pieces of evidence indicate that the cytokine tumor necrosis factor a (TNF-alpha) is an important player in the state of insulin resistance observed during obesity.
|
9609126 |
1998 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that polymorphisms of the TNF-alpha gene are unlikely to contribute to CHD risk in an important way, but the TNF-alpha/-308 polymorphism should be investigated further in relation to obesity.
|
9502188 |
1998 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
|
9502777 |
1998 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In addition, the parallel changes in ob and TNF mRNA in adipose tissue suggest that these two important factors in the defense against obesity may be regulated similarly.
|
9555938 |
1998 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mean mRNA levels of both TNF receptors were two- to threefold higher in adipose tissue samples from the obese than from the non-obese women (P < 0.01 for each).
|
10457150 |
1999 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of TNFalpha and TNF receptors in obesity and insulin resistance.
|
10395191 |
1999 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The tumour necrosis factor (TNF)2 allele appears to be linked with increased insulin resistance and obesity, conditions often found in overweight patients with polycystic ovary syndrome (PCOS).
|
10050654 |
1999 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance.
|
10512379 |
1999 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Susceptible locus for obese type 2 diabetes mellitus in the 5'-flanking region of the tumor necrosis factor-alpha gene.
|
10885566 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Studies in Caucasian subjects have suggested that the G-308A transition in the 5' region of the TNF-alpha gene may be associated with insulin resistance and obesity.
|
10954020 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the results of linkage and association analyses suggest that in hypertensive pedigrees of French-Canadian origin, the TNF-alpha gene locus contributes to the determination of obesity and obesity-associated hypertension.
|
10904006 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF alpha) is a candidate gene for the development of obesity, which in turn is a major risk factor for diabetes mellitus.
|
10672452 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
By comparing the hepatic responses to tumor necrosis factor (TNF)-alpha that occur during situations that promote liver injury (such as obesity or chronic exposure to ethanol) with those that occur after stimuli (such as partial hepatectomy) that lead to liver regeneration, it is apparent that hepatocytes are usually able to constrain noxious responses to TNF-alpha, such as the release of reactive oxygen from mitochondria.
|
10807515 |
2000 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The main objective of this study was to analyze the pathogenic role of the tumor necrosis factor alpha (TNF-alpha) system in the development of nonalcoholic steatohepatitis (NASH).Fifty-two obese patients were studied.
|
11732005 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast to TNF, plasma (rather than adipose) IL-6 demonstrated the strongest relationship with obesity and insulin resistance.
|
11287357 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue.
|
11328671 |
2001 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, a decreased processing rate of mTNF-alpha in mature adipocytes combined with an increase in TNF-alpha production may be a potential mechanism resulting in elevated membrane-associated TNF-alpha in adipose tissue in obesity.
|
12031976 |
2002 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha is a candidate gene for the development of both obesity and insulin resistance.
|
12006640 |
2002 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Weight loss in obese subjects was associated with opposite changes in the secretion and transcription of IL-8 and TNF-alpha in the adipose tissue, as well as in plasma.
|
12055326 |
2002 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present results suggest that the TNF alpha/G-308A polymorphism might interact with other susceptibility factors to coronary heart disease to predispose to insulin resistance, and that the ability of TNF-alpha to induce insulin resistance may extend beyond obesity.
|
11888514 |
2002 |