TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE <b>Methods:</b> In 62 overweight/obese adults (BMI ≥ 25 kg/m<sup>2</sup>; 23F/39M), we collected data on: self-reported back pain; anthropometry [BMI, waist circumference, body composition (dual energy X-ray absorptiometry-DEXA)]; metabolic parameters [fasting glucose; insulin sensitivity (hyperinsulinaemic-euglycaemic clamps)]; cardiovascular parameters (blood pressure, lipids); serum inflammation markers [high-sensitivity C-reactive protein (hsCRP; immunoturbidimetric-assay), tumor necrosis factor-<i>alpha</i> (TNF-α), interleukin (IL)-6, and IL-10 (multiplex-assay)]; and adipokines [leptin, adipsin, resistin, and adiponectin (multiplex-assay)]. 29483883 2018
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated. 17922949 2007
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obesity is associated with the changes of plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-alpha (TNFalpha) and transforming growth factor beta (TGFbeta) levels. 18278185 2008
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE Obesity-dependent association of TNF-LTA locus with type 2 diabetes in North Indians. 20177654 2010
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obesity can be a factor that affects response to anti-TNF drugs. 27908311 2017
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Obesity is associated with high levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), which promotes inflammation in adipose tissue. 28703289 2018
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Obesity is not associated with GCF and salivary resistin and TNF-α levels in children in the presence of gingival inflammation. 29635809 2018
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Obesity is associated to a low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFα. 31130918 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1. 31198543 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obese-ALI animals, compared to Obese-SAL, exhibited increased interventricular septum thickness (<i>p</i> = 0.003) and posterior wall thickness (<i>p</i> = 0.003) and decreased pulmonary acceleration time to pulmonary ejection time ratio (<i>p</i> = 0.005); no changes in lung mechanics, IL-6, TNF-α, TGF-β, PCIII, and PCI in lung tissue; increased IL-10 levels in lung homogenate (<i>p</i> = 0.007); reduced MCP-1 expression in blood neutrophils (<i>p</i> = 0.009); decreased TNF-α expression in blood (<i>p</i> = 0.02) and BALF (<i>p</i> = 0.008) neutrophils; and increased IL-10 expression in monocytes (<i>p</i> = 0.004). 31275296 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Obesity had a negative impact on improvement in the DAS with 28 joints using ESR as an inflammation marker of -0.15 (95% CI: -0.26; -0.04) units for women receiving conventional synthetic DMARDs, -0.22 (95% CI: -0.31; -0.12) units for women receiving TNF inhibitors, -0.22 (95% CI: -0.42; -0.03) units for women receiving tocilizumab and -0.41 (95% CI: -0.74; -0.07) units for men receiving tocilizumab. 31745566 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance. 10512379 1999
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumour necrosis factor alpha (TNF alpha) is a candidate gene for the development of obesity, which in turn is a major risk factor for diabetes mellitus. 10672452 2000
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumor necrosis factor (TNF)-alpha is a candidate gene for the development of both obesity and insulin resistance. 12006640 2002
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Tumour necrosis factor alpha (TNF-alpha), acting as a modulator of gene expression in adipocytes, has been linked to the development of insulin resistance and obesity. 12747594 2003
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumor necrosis factor-alpha (TNF-alpha) has been associated with obesity, obesity-related hypertension, and metabolic syndrome. 16202847 2005
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumour necrosis factor alpha is a multifunctional proinflammatory cytokine involved in the pathogenesis of metabolic syndrome, insulin resistance, and obesity. 21616679 2012
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumour necrosis factor-α (TNF- α)is a major contributor to the pathogenesis of insulin resistance associated with obesity and type 2 diabetes. 23080424 2013
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE TNF-α and PON promoter methylation levels could be involved in the susceptibility to stroke and obesity outcome, respectively. 24500802 2014
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE TNF-α is associated with obesity, but also with anorexia and cachexia. 26472017 2016
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. 26658801 2015
CUI: C0028754
Disease: Obesity
Obesity
0.400 GeneticVariation disease BEFREE Tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPARγ), and insulin receptor substrate-1 (IRS-1) are associated with obesity, insulin resistance, and inflammation. 29256014 2018
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE TNF α, pro-inflammatory cytokine is associated with obesity, insulin resistance and hyperandrogenism, therefore in present study we tried to find the association between TNF α promoter polymorphisms, TNF α levels and the risk of PCOS. 30442458 2019
CUI: C0028754
Disease: Obesity
Obesity
0.400 Biomarker disease BEFREE TNF-α, a pro-inflammatory cytokine is one of the major contributors for metabolic syndromes including insulin resistance, obesity, type II diabetes etc. 31476685 2020
CUI: C0028754
Disease: Obesity
Obesity
0.400 AlteredExpression disease BEFREE Tumor necrosis factor-alpha (TNF-alpha), acting as a modulator of gene expression in adipocytes, is implicated in the development of insulin resistance and obesity. 9287048 1997