TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376154
Disease: Skin callus
Skin callus
0.020 AlteredExpression disease BEFREE High levels of TNF-α influence fracture healing negatively, lead to reduced cartilage and more soft tissue in the callus as well as decreased biomechanical bone stability. 24885217 2014
CUI: C0376154
Disease: Skin callus
Skin callus
0.020 Biomarker disease BEFREE TLR4 knockout promoted fracture healing, reduced the number of osteoclasts, increased bone callus volume (BV) and callus mineralized volume fraction (BV/TV%) (P <  0.05), increased the maximum torque and torsional stiffness of callus (P <  0.05), reduced TNF-α, IL-1β and IL-6 expression (P <  0.01), and increased the expression levels of β-catenin, Wnt4, Wnt5B, PCNA and BMP-2 (P <  0.01). 31796334 2020