(non-specific) purulent meningitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
MRI enhanced FLAIR sequence scan combined with TNF-α in cerebrospinal fluid has the highest rate in early diagnosis of neonatal purulent meningitis, and it is worthy of clinical promotion.
|
30936984 |
2019 |
AA amyloidosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
To date, only in small case series preliminary clinical improvement have been shown with rituximab therapy for AA amyloidosis secondary to RA that is refractory to TNF-α inhibitors (TNF-i) therapy.
|
30400666 |
2018 |
AA amyloidosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Most common serious adverse events were sepsis and thrombotic events observed in 8 and 4 patients, respectively.Treatment with anti-TNFs may be associated with a higher survival rate compared with historic cohorts of AA amyloidosis, especially when started early with a lower serum creatinine level at baseline.
|
28834898 |
2017 |
Abdominal Abscess
|
0.010 |
Biomarker
|
disease |
BEFREE |
This is the first known case where an opportunistic infection with Kocuria has presented with an abdominal abscess in an immunocompromised individual who is on long term TNF inhibitors.
|
27756166 |
2017 |
Abdominal Pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The treatment efficacy of both methods were evaluated by comparing levels of plasma inflammatory cytokines (IL-6, IL-8, TNF-α, C-reactive protein, procalcitonin and leukocyte count), relative indexes of important organs (aspartate aminotransferase, alanine aminotransferase, creatinine and urea nitrogen) and other clinical data (amelioration time of abdominal pain and abdominal distension, Balthazar CT scores, acute physiology and chronic health enquiry II score, length of hospital stay, complications and prognosis).
|
29843500 |
2019 |
Abdominal symptom
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
The present study aimed to explore the correlation between cytokine expression of tumor necrosis factor α (TNF‑α), interleukin (IL)‑8 and IL‑10 with occludin production, abdominal symptoms and psychological factors in patients with irritable bowel syndrome‑associated diarrhea (IBS‑D).
|
26180016 |
2015 |
Abdominal symptom
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Since tumor necrosis factor (TNF) α is responsible for the pathogenesis of NEMO colitis according to intestinal NEMO and additional TNFR1 knockout mice studies, and high levels of TNFα-producing mononuclear cells were detected in the patient due to the unexpected gene reversion mosaicism of NEMO, an anti-TNFα monoclonal antibody was administered to ameliorate his abdominal symptoms.
|
21993693 |
2012 |
ABLEPHARON-MACROSTOMIA SYNDROME
|
0.010 |
Biomarker
|
disease |
BEFREE |
Acute phase proteins and inflammatory cytokines (IL-1β, IL-6, and TNF-α) show significant changes between the AMS group and the non-AMS group.
|
29608374 |
2018 |
Abnormal behavior
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, both TNF-α inhibition and microglia depletion revert such behavioral abnormality.
|
31509752 |
2019 |
Abnormal behavior
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Psychiatric disorders are correlated with elevated levels of CRP, pro-inflammatory cytokines (IL-6, IL-1β and TNFα) and anti-inflammatory factors (TGF β, IL-10, sIL-2, IL-1RA).
|
30439824 |
2018 |
Abnormal behavior
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
There were decreased 5-HT concentrations and upregulated TNF-α mRNA levels that were accompanied by behavioral changes.
|
31616368 |
2019 |
Abnormal behavior
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that the transient upregulation of microglia and TNFα in the mPFC induced by adolescent social stress may participate in the development of cognitive flexibility deficit and that immunomodulation may act as a potential target for the early prevention of cognitive deficits in psychiatric disorders.
|
31381975 |
2019 |
Abnormal behavior
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems.
|
29324697 |
2018 |
Abnormal behavior
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Despite the unexpected decrease in IL-6 and unchanged TNF-α levels contrast to the expected pro-inflammatory phenotype, this may suggest that reduced anti-inflammatory signalling may be critical for eliciting abnormal behaviour in adulthood.
|
30686977 |
2018 |
Abnormal behavior
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
LPS triggered an inflammatory response characterized by glial activation [Iba-1 and glial fibrillary acidic protein (GFAP)] and pro-inflammatory cytokine production (TNF-α and IL-1β) leading to extensive dopaminergic loss and behavioral abnormality in rats.
|
28409389 |
2017 |
Abnormal behavior
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
In addition, lipopolysaccharide-induced increase in tumor necrosis factor-α (TNF-α) in the hippocampus antagonized the beneficial effects of EE for these behavioral abnormalities in mice with neuropathic pain.
|
30798405 |
2019 |
Abnormality of limbs
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Increased risk of limb anomaly was observed for three SNPs: heterozygosity for F5 Arg506Gln, with an odds ratio (OR) of 2.5 (95% confidence interval (CI), 1.0, 6.5); heterozygosity for TNF (-376)G > A, OR 2.1 (0.7, 6.2); and homozygosity for NPPA 2238T > C, OR 4.0 (1.1, 15.4).
|
17036337 |
2006 |
ABO incompatibility
|
0.020 |
Biomarker
|
disease |
BEFREE |
Nor did neutralizing antibodies to tumor necrosis factor prevent MCP-1 production in ABO incompatibility.
|
8273123 |
1994 |
ABO incompatibility
|
0.020 |
Biomarker
|
disease |
BEFREE |
We have constructed an in vitro whole blood model of HTR to examine whether TNF may be produced in red cell ABO incompatibility.
|
1911345 |
1991 |
Abscess
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Few data are available on the effects of tumor necrosis factor (TNF) antagonist therapy for patients with internal fistulizing Crohn's disease (CD) and there is debate over the risk of abscess.
|
31128337 |
2020 |
Abscess
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses.
|
17511783 |
2007 |
Absence of sensation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Multimodality approach was defined as using a combination of medical treatments (anti-TNFs ± immunomodulators ± antibiotics) along with surgical approach (examination under anaesthesia (EUA) ± seton drainage) at diagnosis of CD-pAF.
|
30226271 |
2018 |
Absence of sensation
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
One hundred patients admitted for elective AAA repair had plasma levels of interleukin (IL) 1beta, IL-6, IL-10 and tumour necrosis factor (TNF) alpha measured at induction of anaesthesia and 24 h after operation.
|
12945076 |
2003 |
Acanthosis Nigricans
|
0.010 |
Biomarker
|
disease |
BEFREE |
BMI, fasting insulin (FINS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), tumor necrosis factor-α (TNF-α) and total testosterone (TT) were significantly changed in both groups, while interleukin (IL)-6, IL-8 and C-reactive protein were changed significantly only in the AN group.
|
30724385 |
2019 |
Achalasia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The rs1799724 SNP located between the lymphotoxin-α (LTA) and tumour necrosis factor-α (TNFα) genes was significantly associated with achalasia and withstood correction for testing multiple SNPs (p=1.17E-4, OR=1.41 (1.18 to 1.67)).
|
24259423 |
2014 |