TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0865440
Disease: (non-specific) purulent meningitis
(non-specific) purulent meningitis
0.010 Biomarker disease BEFREE MRI enhanced FLAIR sequence scan combined with TNF-α in cerebrospinal fluid has the highest rate in early diagnosis of neonatal purulent meningitis, and it is worthy of clinical promotion. 30936984 2019
CUI: C3536715
Disease: AA amyloidosis
AA amyloidosis
0.020 Biomarker disease BEFREE To date, only in small case series preliminary clinical improvement have been shown with rituximab therapy for AA amyloidosis secondary to RA that is refractory to TNF-α inhibitors (TNF-i) therapy. 30400666 2018
CUI: C3536715
Disease: AA amyloidosis
AA amyloidosis
0.020 Biomarker disease BEFREE Most common serious adverse events were sepsis and thrombotic events observed in 8 and 4 patients, respectively.Treatment with anti-TNFs may be associated with a higher survival rate compared with historic cohorts of AA amyloidosis, especially when started early with a lower serum creatinine level at baseline. 28834898 2017
CUI: C0243001
Disease: Abdominal Abscess
Abdominal Abscess
0.010 Biomarker disease BEFREE This is the first known case where an opportunistic infection with Kocuria has presented with an abdominal abscess in an immunocompromised individual who is on long term TNF inhibitors. 27756166 2017
CUI: C0000737
Disease: Abdominal Pain
Abdominal Pain
0.010 Biomarker phenotype BEFREE The treatment efficacy of both methods were evaluated by comparing levels of plasma inflammatory cytokines (IL-6, IL-8, TNF-α, C-reactive protein, procalcitonin and leukocyte count), relative indexes of important organs (aspartate aminotransferase, alanine aminotransferase, creatinine and urea nitrogen) and other clinical data (amelioration time of abdominal pain and abdominal distension, Balthazar CT scores, acute physiology and chronic health enquiry II score, length of hospital stay, complications and prognosis). 29843500 2019
CUI: C0740651
Disease: Abdominal symptom
Abdominal symptom
0.020 AlteredExpression phenotype BEFREE The present study aimed to explore the correlation between cytokine expression of tumor necrosis factor α (TNF‑α), interleukin (IL)‑8 and IL‑10 with occludin production, abdominal symptoms and psychological factors in patients with irritable bowel syndrome‑associated diarrhea (IBS‑D). 26180016 2015
CUI: C0740651
Disease: Abdominal symptom
Abdominal symptom
0.020 Biomarker phenotype BEFREE Since tumor necrosis factor (TNF) α is responsible for the pathogenesis of NEMO colitis according to intestinal NEMO and additional TNFR1 knockout mice studies, and high levels of TNFα-producing mononuclear cells were detected in the patient due to the unexpected gene reversion mosaicism of NEMO, an anti-TNFα monoclonal antibody was administered to ameliorate his abdominal symptoms. 21993693 2012
CUI: C1860224
Disease: ABLEPHARON-MACROSTOMIA SYNDROME
ABLEPHARON-MACROSTOMIA SYNDROME
0.010 Biomarker disease BEFREE Acute phase proteins and inflammatory cytokines (IL-1β, IL-6, and TNF-α) show significant changes between the AMS group and the non-AMS group. 29608374 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 Biomarker phenotype BEFREE Furthermore, both TNF-α inhibition and microglia depletion revert such behavioral abnormality. 31509752 2019
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 AlteredExpression phenotype BEFREE Psychiatric disorders are correlated with elevated levels of CRP, pro-inflammatory cytokines (IL-6, IL-1β and TNFα) and anti-inflammatory factors (TGF β, IL-10, sIL-2, IL-1RA). 30439824 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 AlteredExpression phenotype BEFREE There were decreased 5-HT concentrations and upregulated TNF-α mRNA levels that were accompanied by behavioral changes. 31616368 2019
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 Biomarker phenotype BEFREE These results suggest that the transient upregulation of microglia and TNFα in the mPFC induced by adolescent social stress may participate in the development of cognitive flexibility deficit and that immunomodulation may act as a potential target for the early prevention of cognitive deficits in psychiatric disorders. 31381975 2019
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 AlteredExpression phenotype BEFREE Cord blood adiponectin, TNF-α and IL-6 levels were not associated with child behavioral problems. 29324697 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 AlteredExpression phenotype BEFREE Despite the unexpected decrease in IL-6 and unchanged TNF-α levels contrast to the expected pro-inflammatory phenotype, this may suggest that reduced anti-inflammatory signalling may be critical for eliciting abnormal behaviour in adulthood. 30686977 2018
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 Biomarker phenotype BEFREE LPS triggered an inflammatory response characterized by glial activation [Iba-1 and glial fibrillary acidic protein (GFAP)] and pro-inflammatory cytokine production (TNF-α and IL-1β) leading to extensive dopaminergic loss and behavioral abnormality in rats. 28409389 2017
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior
0.080 Biomarker phenotype BEFREE In addition, lipopolysaccharide-induced increase in tumor necrosis factor-α (TNF-α) in the hippocampus antagonized the beneficial effects of EE for these behavioral abnormalities in mice with neuropathic pain. 30798405 2019
CUI: C1387925
Disease: Abnormality of limbs
Abnormality of limbs
0.010 GeneticVariation phenotype BEFREE Increased risk of limb anomaly was observed for three SNPs: heterozygosity for F5 Arg506Gln, with an odds ratio (OR) of 2.5 (95% confidence interval (CI), 1.0, 6.5); heterozygosity for TNF (-376)G > A, OR 2.1 (0.7, 6.2); and homozygosity for NPPA 2238T > C, OR 4.0 (1.1, 15.4). 17036337 2006
CUI: C0860218
Disease: ABO incompatibility
ABO incompatibility
0.020 Biomarker disease BEFREE Nor did neutralizing antibodies to tumor necrosis factor prevent MCP-1 production in ABO incompatibility. 8273123 1994
CUI: C0860218
Disease: ABO incompatibility
ABO incompatibility
0.020 Biomarker disease BEFREE We have constructed an in vitro whole blood model of HTR to examine whether TNF may be produced in red cell ABO incompatibility. 1911345 1991
CUI: C0000833
Disease: Abscess
Abscess
0.020 GeneticVariation phenotype BEFREE Few data are available on the effects of tumor necrosis factor (TNF) antagonist therapy for patients with internal fistulizing Crohn's disease (CD) and there is debate over the risk of abscess. 31128337 2020
CUI: C0000833
Disease: Abscess
Abscess
0.020 GeneticVariation phenotype BEFREE Association of CD14, IL1B, IL6, IL10 and TNFA functional gene polymorphisms with symptomatic dental abscesses. 17511783 2007
CUI: C0278134
Disease: Absence of sensation
Absence of sensation
0.020 Biomarker phenotype BEFREE Multimodality approach was defined as using a combination of medical treatments (anti-TNFs ± immunomodulators ± antibiotics) along with surgical approach (examination under anaesthesia (EUA) ± seton drainage) at diagnosis of CD-pAF. 30226271 2018
CUI: C0278134
Disease: Absence of sensation
Absence of sensation
0.020 Biomarker phenotype BEFREE One hundred patients admitted for elective AAA repair had plasma levels of interleukin (IL) 1beta, IL-6, IL-10 and tumour necrosis factor (TNF) alpha measured at induction of anaesthesia and 24 h after operation. 12945076 2003
CUI: C0000889
Disease: Acanthosis Nigricans
Acanthosis Nigricans
0.010 Biomarker disease BEFREE BMI, fasting insulin (FINS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), tumor necrosis factor-α (TNF-α) and total testosterone (TT) were significantly changed in both groups, while interleukin (IL)-6, IL-8 and C-reactive protein were changed significantly only in the AN group. 30724385 2019
CUI: C1321756
Disease: Achalasia
Achalasia
0.020 GeneticVariation disease BEFREE The rs1799724 SNP located between the lymphotoxin-α (LTA) and tumour necrosis factor-α (TNFα) genes was significantly associated with achalasia and withstood correction for testing multiple SNPs (p=1.17E-4, OR=1.41 (1.18 to 1.67)). 24259423 2014