Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
One implication of this study, in individuals genetically predetermined to be low TNF-alpha producers, is that additional inhibition of TNF-alpha production by routine immunosuppression may be excessive, rendering these individuals less able to respond to infectious stimuli.
|
10221485 |
1999 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF-alpha) appears important in ultraviolet-induced immunosuppression, suggesting that it is a susceptibility candidate for cutaneous basal cell carcinoma (BCC).
|
10735947 |
2000 |
Immunosuppression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Children successfully maintained off immunosuppression are more likely to have a genetic predisposition toward low TNF-alpha and high/intermediate IL-10 production.
|
11981433 |
2002 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mechanisms underlying induction of UVB-induced immunosuppression are not fully understood, but tumor necrosis factor alpha (TNF-alpha) is suggested to play a central role.
|
14714556 |
2003 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pharmacological immunosuppression for GVHD prophylaxis and therapy, including unspecific approaches with corticosteroids or methotrexate (MTX), as well as more specific therapy with cyclosporin A (CsA), tacrolimus (FK506), sirolimus, mycophenolate mofetil (MMF), antithymocyte globulin (ATG), and monoclonal antibodies (MAbs) directed against CD3, CD25, CD52, cytotoxic T-lymphocyte antigen (CTLA)-4, CD40 ligand, or TNF-alpha, have been proven to be effective.
|
15449032 |
2004 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Exogenous administration of recombinant TNF-alpha to H310A1-infected mice for 4 days abrogated immunosuppression.
|
17038643 |
2006 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low TNF-α concentrations 300 min after sepsis induction could be interpreted as considerable immunosuppression during CLI sepsis.
|
21296198 |
2011 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transplant derived differentiated airway epithelial cell IL-6, IL-8, and TNF-α secretion is not regulated by cyclosporine in vitro; these cells thus may participate in local inflammatory responses in the setting of immunosuppression.
|
21477368 |
2011 |
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Once epidermal genetic mutations and aberrant molecular signaling have occurred, the stroma responds through a 3-phase process-extracellular matrix degradation is produced by matrix metalloproteinases; angiogenesis is induced by vascular endothelial growth factor and mast cell mediators; and the inflammatory response is elicited by cytokines and cyclin D1 overexpression balanced by the immunosuppression of mast cell mediators such as tumor necrosis factor alpha, histamine, and transforming growth factor beta.
|
21785326 |
2011 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Steroid intake and immunosuppression are risk factors and only recently a glucocorticoid-induced tumor necrosis factor-receptor has been suggested to resemble the molecular link.
|
22711236 |
2012 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Defective TNF-α production is a major trait of sepsis-induced immunosuppression.
|
28274246 |
2017 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Little is known about the risk of serious infection when combining anti-tumour necrosis factor [TNF] therapy for refractory inflammatory bowel disease [IBD] with immunosuppression after liver transplantation [LT].
|
28482085 |
2017 |
Immunosuppression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study investigated whether therapy with TNF inhibitors suppresses the TST reaction due to immunosuppression or whether the TST reaction increases due to reactivation of latent Mycobacterium tuberculosis infection.
|
28524434 |
2017 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNFα response: A diagnostic tool for immunosuppression?
|
28771573 |
2017 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, prolonged use of TNFα inhibitor (TNFαi) can induce widespread, significant immunosuppression, which can negatively impact the antitumour efficacy of ICI therapy.
|
28830882 |
2017 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α is also known to promote UVB-induced inflammation, apoptosis, and immunosuppression.
|
29228682 |
2017 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
This case suggests a potential relationship between immunosuppression with anti-TNFα medication, and increased risk for lymphoma, especially in patients with underlying rheumatologic disorders and especially in patients with suspected chronic refractory uveitis.
|
29954352 |
2018 |
Immunosuppression
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We present the case of a 16-year-old boy with NCM who developed malignant leptomeningeal melanoma following immunosuppression with a TNFα inhibitor.
|
30868657 |
2019 |
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke.
|
30972077 |
2019 |
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consistent with the <i>in vitro</i> results, HT-LM1004 increased TNF-<i>α</i>, IFN-<i>γ</i>, IL-2, and IL-12p70 levels in mice after 14 days of treatment and enhanced the natural killer (NK) cell activity of splenocytes from mice with CTX-induced immunosuppression against YAC-1 lymphoma cells.
|
31216204 |
2019 |
Immunosuppression
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results showed that PCB126 caused immunosuppression as evidenced by inhibiting the ratios of thymus and spleen weights, changing the organizational structure and decreasing levels and mRNA expression of TNF-α, IFN-γ and IL-2.
|
31563530 |
2019 |
Immunosuppression
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that immunosuppression (HR 0.38) and treatment with anti-TNF for > 1 year (HR 0.30) were associated with a decreased likelihood of transitioning from stage B1 to pB3.
|
31797187 |
2019 |