Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis.
|
1702929 |
1991 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha.
|
7744320 |
1995 |
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that this promoter polymorphism itself or a gene in linkage disequilibrium with tumor necrosis factor-alpha predispose to the development of psoriasis.
|
9326391 |
1997 |
Psoriasis
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
The G-->A polymorphism at position -308 of the tumor necrosis factor-alpha promoter was less frequent in type I psoriasis (23%) compared with controls (35.7%), although the negative association was weak [0.54 (0.3-0.97); p = 0.041; pcorr = not significant].
|
10469306 |
1999 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The promoter allele TNF238.2 seems to influence tumor necrosis factor alpha production; a possible role in the pathogenesis of psoriasis has to be further evaluated.
|
10844563 |
2000 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Psoriasis is associated with an overexpression in the involved skin of T-helper cell type 1 (Th1) cytokines, e.g. interferon (IFN) -gamma and tumour necrosis factor (TNF) alpha and relative underexpression of Th2 cytokines, e.g. interleukin (IL) -4 and IL-10.
|
11298547 |
2001 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Carriage of tumor necrosis factor A-238 allele 2 (-238*A) was associated with increased production of tumor necrosis factor-alpha in response to lipopolysaccharide in vitro, and with early onset disease (< 40 y), especially in male patients with psoriasis [32% vs 7% in male controls; odds ratio = 6.78, 95% confidence interval = (3.18-15.15), p(adjusted) = 2 x 10(-7)].
|
11851889 |
2002 |
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the frequency of TNFA allele -238A was not increased in the total PsA group or in patients with a younger age of onset of psoriasis, TNFA allele -238A was absent in the spondyloarthritis group and increased in frequency in patients with peripheral polyarthritis.
|
12011375 |
2002 |
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This suggests that TNFA gene promoter polymorphism in the region examined is less associated with the pathogenesis of psoriasis in Japanese patients, however there might be the possibility that TNFA gene promoter polymorphism is associated with GPP.
|
12234707 |
2002 |
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We aimed to determine whether Cw6 and the genetic polymorphism of the CDSN gene, POU5F1 gene, MICA gene and the gene for TNF-alpha promoter region were associated with an increased risk of psoriasis in Chinese patients.
|
12653732 |
2003 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis.
|
12709814 |
2003 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
There are over 300,000 patients worldwide being treated with agents that specifically block the biological activities of interleukin-1 (IL-1) or tumor necrosis factor (TNF) for reducing the severity of autoimmune diseases such as rheumatoid arthritis, Crohn's disease or psoriasis.
|
12763679 |
2003 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A subsequent clinical trial evaluated infliximab in a patient with CD and psoriasis, another disease in which increased levels of tumor necrosis factor-alpha are seen in lesions.
|
12789169 |
2003 |
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is in contrast to the recently described association between psoriasis and the TNFA-238 and IL1B-511 polymorphisms.
|
12828754 |
2003 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.
|
14981113 |
2004 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Biology of tumor necrosis factor-alpha- implications for psoriasis.
|
15086336 |
2004 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As compared to normal skin (n = 7), there was an increased expression of TNF-alpha, IL-12p40, and IL-8, a decreased expression of TGF-beta1, and a lack of IL-10, similar to the findings in active psoriasis (n = 8).
|
15186319 |
2004 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective.
|
15251081 |
2004 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
It was proposed that TNF-alpha is involved in the pathogenesis of psoriasis, and it is therefore suggested that TACE has important roles in psoriasis.
|
15888146 |
2005 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques.
|
16081850 |
2005 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results strongly suggest that increased activation of MK2 is responsible for the elevated and posttranscriptionally regulated TNF-alpha protein expression in psoriatic skin, making MK2 a potential target in the treatment of psoriasis.
|
16424170 |
2006 |
Psoriasis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-alpha and interferon-gamma (IFN-gamma), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis.
|
16441627 |
2006 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Possible association of psoriasis and reduced bone mineral density due to increased TNF-alpha and IL-6 concentrations.
|
16844318 |
2006 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis.
|
17074928 |
2006 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene expression changes in psoriasis lesions have been well documented, and strongly support an important role for tumor necrosis factor and interferon gamma signal pathways in its pathogenesis.
|
17093502 |
2007 |