TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE Cellular localization of interleukin-8 and its inducer, tumor necrosis factor-alpha in psoriasis. 1702929 1991
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease CTD_human Increased mRNA expression of manganese superoxide dismutase in psoriasis skin lesions and in cultured human keratinocytes exposed to IL-1 beta and TNF-alpha. 7744320 1995
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE Our findings suggest that this promoter polymorphism itself or a gene in linkage disequilibrium with tumor necrosis factor-alpha predispose to the development of psoriasis. 9326391 1997
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 PosttranslationalModification disease BEFREE The G-->A polymorphism at position -308 of the tumor necrosis factor-alpha promoter was less frequent in type I psoriasis (23%) compared with controls (35.7%), although the negative association was weak [0.54 (0.3-0.97); p = 0.041; pcorr = not significant]. 10469306 1999
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE The promoter allele TNF238.2 seems to influence tumor necrosis factor alpha production; a possible role in the pathogenesis of psoriasis has to be further evaluated. 10844563 2000
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 AlteredExpression disease BEFREE Psoriasis is associated with an overexpression in the involved skin of T-helper cell type 1 (Th1) cytokines, e.g. interferon (IFN) -gamma and tumour necrosis factor (TNF) alpha and relative underexpression of Th2 cytokines, e.g. interleukin (IL) -4 and IL-10. 11298547 2001
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE This suggests that TNFA gene promoter polymorphism in the region examined is less associated with the pathogenesis of psoriasis in Japanese patients, however there might be the possibility that TNFA gene promoter polymorphism is associated with GPP. 12234707 2002
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE Carriage of tumor necrosis factor A-238 allele 2 (-238*A) was associated with increased production of tumor necrosis factor-alpha in response to lipopolysaccharide in vitro, and with early onset disease (< 40 y), especially in male patients with psoriasis [32% vs 7% in male controls; odds ratio = 6.78, 95% confidence interval = (3.18-15.15), p(adjusted) = 2 x 10(-7)]. 11851889 2002
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE Although the frequency of TNFA allele -238A was not increased in the total PsA group or in patients with a younger age of onset of psoriasis, TNFA allele -238A was absent in the spondyloarthritis group and increased in frequency in patients with peripheral polyarthritis. 12011375 2002
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE There are over 300,000 patients worldwide being treated with agents that specifically block the biological activities of interleukin-1 (IL-1) or tumor necrosis factor (TNF) for reducing the severity of autoimmune diseases such as rheumatoid arthritis, Crohn's disease or psoriasis. 12763679 2003
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE We aimed to determine whether Cw6 and the genetic polymorphism of the CDSN gene, POU5F1 gene, MICA gene and the gene for TNF-alpha promoter region were associated with an increased risk of psoriasis in Chinese patients. 12653732 2003
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 AlteredExpression disease BEFREE A subsequent clinical trial evaluated infliximab in a patient with CD and psoriasis, another disease in which increased levels of tumor necrosis factor-alpha are seen in lesions. 12789169 2003
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE Polymorphisms of tumor necrosis factor (TNF) alpha and beta genes in Korean patients with psoriasis. 12709814 2003
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE This is in contrast to the recently described association between psoriasis and the TNFA-238 and IL1B-511 polymorphisms. 12828754 2003
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE Tumor necrosis factor-alpha in psoriasis and psoriatic arthritis: a clinical, genetic, and histopathologic perspective. 15251081 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 AlteredExpression disease BEFREE As compared to normal skin (n = 7), there was an increased expression of TNF-alpha, IL-12p40, and IL-8, a decreased expression of TGF-beta1, and a lack of IL-10, similar to the findings in active psoriasis (n = 8). 15186319 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE Biology of tumor necrosis factor-alpha- implications for psoriasis. 15086336 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha. 14981113 2004
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE It was proposed that TNF-alpha is involved in the pathogenesis of psoriasis, and it is therefore suggested that TACE has important roles in psoriasis. 15888146 2005
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 AlteredExpression disease BEFREE TNF inhibition rapidly down-regulates multiple proinflammatory pathways in psoriasis plaques. 16081850 2005
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease BEFREE IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2-dependent mechanisms with implications for psoriasis pathogenesis. 17074928 2006
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 AlteredExpression disease BEFREE The results strongly suggest that increased activation of MK2 is responsible for the elevated and posttranscriptionally regulated TNF-alpha protein expression in psoriatic skin, making MK2 a potential target in the treatment of psoriasis. 16424170 2006
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE These skin-infiltrating lymphocytes might trigger, by the local production of Th-1 cytokines such as TNF-alpha and interferon-gamma (IFN-gamma), the eruption of psoriatic plaques in patients with a genetic predisposition for psoriasis. 16441627 2006
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 Biomarker disease CTD_human Possible association of psoriasis and reduced bone mineral density due to increased TNF-alpha and IL-6 concentrations. 16844318 2006
CUI: C0033860
Disease: Psoriasis
Psoriasis
0.400 GeneticVariation disease BEFREE We found that the TNF-alpha-308A allele frequency was significantly decreased among patients with early-onset psoriasis in comparison with control subjects (7.5% vs. 15.4%, P = 0.022), whereas in the same patients the frequency of the TNF-alpha-238A allele was significantly increased as compared with the controls (16.8% vs. 3.1%, P = 0.000017, odds ratio 8.79, 95% confidence interval 2.606-29.678). 17553030 2007