TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333293
Disease: Healing ulcer
Healing ulcer
0.030 AlteredExpression disease BEFREE The ulcer healing activity was also associated with significant increases in gastric mucin content, collagen deposition, number of cells with positive marking for proliferating cell nuclear antigen (PCNA), and by changes in the expression of the inflammatory parameters tumor necrosis factor (TNF)-α, interleukin (IL)-1β and cyclooxygenase (COX)-2, as well as a decrease of metalloproteinases (MMP-9 and MMP-2) activity. 30991046 2019
CUI: C0333293
Disease: Healing ulcer
Healing ulcer
0.030 AlteredExpression disease BEFREE This study demonstrated that compared to CS alone, TNF-i improve disease activity and possess a higher ulcer healing effect and CS tapering effect with or without concomitant CS. 31228955 2019
CUI: C0333293
Disease: Healing ulcer
Healing ulcer
0.030 Biomarker disease BEFREE Together, these data support the hypothesis that TNF plays a beneficial role in enhancing Wnt/β-catenin signaling during ulcer healing in IBD. 28747340 2017