Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Results revealed that increased hyperalgesia was concurrent with an increment of Iba1 (P < 0.001), TNF-α (P < 0.001), PTEN (P < 0.01), cleaved caspase-3 (P < 0.001), and a decrement of P.Akt (P < 0.01) during the acute phase of CFA-induced inflammation, while, at the same time as decreasing hyperalgesia during the chronic phase of study, Iba1 and TNF-α expression significantly decreased and PTEN, cleaved caspase-3, and P.Akt restored to baseline on day 0.
|
31388881 |
2020 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In the present research, neuropathic pain induced Nrf2 and HO-1 expression in the microglial cells of the spinal cord; Nrf2 and HO-1 were necessary to alleviate the hyperalgesia of CCI-induced rats; NaHS mitigated the hyperalgesia and allodynia induced by the CCI operation; and NaHS mitigated the excessive release of the cytokines TNF-α, IL-1β, IL-6 and HMGB1 via the Nrf2/HO-1 pathway in the microglial cells of the spinal cord.
|
31325725 |
2019 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
In the present study, we evaluated RAc1 nano particle effects on hyperalgesia and liver hepcidin and serum IL-1β and TNF-α expression levels during acute and chronic phases of adjuvant-induced inflammation in male rats and compared its effects with Deferoxamine.
|
30776642 |
2019 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Immediately after hyperalgesia tests, blood samples were collected to analyze creatine kinase (CK) activity and the soleus muscle was removed for histological and tumor necrosis factor (TNF)-α immunohistological analyses.
|
30328526 |
2019 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The α7 nicotinic acetylcholine receptor positive allosteric modulator prevents lipopolysaccharide-induced allodynia, hyperalgesia and TNF-α in the hippocampus in mice.
|
31655281 |
2019 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Selective astrocyte (α-aminoadipate) and microglia (minocycline) inhibitors were injected i.t. to determine the contribution of these cells to hyperalgesia and paw edema.The effects of i.t. treatments with glial and NFκB (PDTC) inhibitors on spinal glial activation, TNF-α, IL-1β, CX<sub>3</sub>CR1 and CX<sub>3</sub>CL1 mRNA expression, and NFκB activation were also evaluated.
|
31138231 |
2019 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The aim of the current study was to investigate the effects of those two modalities on pain behavior and the expression of pro-inflammatory cytokines such as interleukin (IL)-1β and IL-6 and tumor necrosis factor-α (TNF-α) in the spinal cord and dorsal root ganglion (DRG) in a rat model of perioperative fentanyl induced hyperalgesia.
|
29657246 |
2018 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we tried to investigate behavioral hyperalgesia, the expression of proinflammatory cytokines, such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and the activation of microglia in the spinal cord and dorsal root ganglion (DRG) in a rat model of surgical plantar incision with or without perioperative fentanyl.
|
29135586 |
2018 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The objective of this study was to evaluate the effects of photobiomodulation therapy (PBMT) on inflammatory indicators, i.e., inflammatory mediators (TNF-α and CINC-1), and pain characterized by hyperalgesia and B1 and B2 receptor activation at 6, 24, and 48 h after papain-induced osteoarthritis (OA) in rats.
|
27726041 |
2017 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
TXYF improves PI-IBS symptoms by alleviating behavioral hyperalgesia and antidiarrhea, the underlying mechanism of which involves the inhibitory effects of TXYF on activating mucosal mast cells, downregulating tryptase and c-Fos expression, and reducing serum TNF-<i>α</i> and histamine levels.
|
28331524 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Chronic exposure to tumor necrosis factor in vivo induces hyperalgesia, upregulates sodium channel gene expression and alters the cellular electrophysiology of dorsal root ganglion neurons.
|
28558976 |
2017 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
The CE and dichloromethane and hexane fractions reduced Cg-induced paw edema and hyperalgesia, LPS-induced fever, and plasma tumor necrosis factor-α (TNF-α) levels.
|
28332176 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Inhibition of TNF reduces mechanical orofacial hyperalgesia induced by Complete Freund's Adjuvant by a TRPV1-dependent mechanism in mice.
|
29132095 |
2017 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Vincristine injection induced allodynia and hyperalgesia (n = 12), activated tumor necrosis factor-α/nuclear factor-κB signaling, and reduced free Mg in cerebrospinal fluid by 21.7 ± 6.3% (mean ± SD; n = 13) and in dorsal root ganglion neurons by 27 ± 6% (n = 11).
|
28306698 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Leishmania (L). amazonensis induces hyperalgesia in balb/c mice: Contribution of endogenous spinal cord TNFα and NFκB activation.
|
28219639 |
2017 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Resveratrol suppresses glial activation and alleviates trigeminal neuralgia via activation of AMPK.
|
27093858 |
2016 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Citronellol, a natural acyclic monoterpene, attenuates mechanical hyperalgesia response in mice: Evidence of the spinal cord lamina I inhibition.
|
26141506 |
2015 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Curcumin significantly attenuated the diabetes-induced allodynia and hyperalgesia and reduced the expression of both TNF-α and TNF-α receptor 1.
|
23471081 |
2013 |
Hyperalgesia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
TST led to significant development of cold allodynia; mechanical and heat hyperalgesia; dynamic mechanical allodynia; functional deficit in walking along with rise in the levels of TBARS, TNF-α, GSH and Nitrite.
|
24499201 |
2013 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions.
|
20383154 |
2010 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Thus, increased sensitization and up-regulation of TRPV1 constitutes a potential mechanism by which TNFalpha mediates inflammatory hyperalgesia and pain.
|
18582539 |
2008 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
We propose endogenous TNFalpha as a key player in cancer-related heat hyperalgesia and nociceptor sensitization that generates TRPV1 upregulation and sensitization via TNFR2.
|
18463260 |
2008 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Anti-inflammatory and analgesic effects of the sesquiterpene lactone budlein A in mice: inhibition of cytokine production-dependent mechanism.
|
17320857 |
2007 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Anti-TNF-alpha antibody reduces pain-behavioral changes induced by epidural application of nucleus pulposus in a rat model depending on the timing of administration.
|
17304130 |
2007 |
Hyperalgesia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Peri-sciatic administration of recombinant rat TNF-alpha induces mechanical allodynia via upregulation of TNF-alpha in dorsal root ganglia and in spinal dorsal horn: the role of NF-kappa B pathway.
|
17459378 |
2007 |