Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ABCB1 (MDR1), APOE, BDNF, CNR1, COMT, DAT1 (SLC6A3), DRD4, ESR1, HLA-DRB1, IL10, IL1B, IL6, LTA, PTGS2 (COX-2), SLC6A4, and TNF were associated with cognitive impairment and pain, which had the most genes in common.
|
29325450 |
2018 |
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-alpha -1031T/C polymorphism is associated with cognitive deficits in chronic schizophrenia patients versus healthy controls.
|
29633506 |
2018 |
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of TNF-α (rs1800629) and IL-6 (rs1800795) Polymorphisms on Cognitive Impairment in Asian Breast Cancer Patients.
|
27701469 |
2016 |
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Expression of IL-6, IL-8, and TNF-<i>α</i> in the two groups was reduced significantly with variation of the clinical scales of cognitive impairment.
|
29853963 |
2018 |
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration.
|
30193769 |
2018 |
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that the SNP -1031T>C of the TNF-alpha gene may not be associated with susceptibility to schizophrenia but possibly acts as a modulator for its onset age as well as for cognitive deficits.
|
30855153 |
2019 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Single studies suggest the role of CRP, interleukin(IL)-1 receptor antagonist, IL-6 and TNF-α with its receptors in the development of cognitive impairment in BD.
|
28416092 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The triangle of death of neurons: Oxidative damage, mitochondrial dysfunction, and loss of choline-containing biomolecules in brains of mice treated with doxorubicin. Advanced insights into mechanisms of chemotherapy induced cognitive impairment ("chemobrain") involving TNF-α.
|
30593843 |
2019 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Various pro-inflammatory cytokines, such as TNFα, maintain a state of chronic neuroinflammation, manifesting as post-operative cognitive dysfunction and post-operative delirium.
|
30348620 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that TNF-α is associated with cognitive and functional decline and that inflammation could be a substrate of cognitive impairment at early clinical stages of dementia.
|
30150062 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The potential for exercise to regulate human TNF and TNF signalling and cognitive dysfunction needs investigation under inflammatory conditions including depression and neuropsychiatric disorders.
|
29969604 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the transient upregulation of microglia and TNFα in the mPFC induced by adolescent social stress may participate in the development of cognitive flexibility deficit and that immunomodulation may act as a potential target for the early prevention of cognitive deficits in psychiatric disorders.
|
31381975 |
2019 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease.
|
28157092 |
2017 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Phase I and IIa clinical trials suggest that TNF-α inhibitors might slow down cognitive decline and improve daily activities in AD patients.
|
27697064 |
2017 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings provided preliminary evidence that the interaction of BDNF and TNF-α may confer susceptibility to schizophrenia and cognitive dysfunction.
|
29306772 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early elevations of C-reactive protein, tumor necrosis factor-α, interleukin (IL)-8, intercellular adhesion molecule (ICAM)-1, and erythropoietin were associated with IQ values >2 SD below the expected mean (ORs: 2.0-2.3) and with moderate to severe cognitive impairment on a composite measure of IQ and executive function (ORs: 2.1-3.6).
|
27788929 |
2017 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results exhibited that CB treatment prevented cognitive impairment, Aβ deposits, microglia activation and production of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the brain of APP/PS1 mice.
|
31835282 |
2020 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study investigates the potential of trans-Sinapic Acid as neuromodulator and its effect on release of Monoamine Oxidase (MAO-A, MAO-B), TNF-α, Acetylcholine esterase Enzyme, in cognitive dysfunctions associated with experimental dementia.
|
29521253 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytokines such as TNFα play an integral role in sleep/wake regulation and have recently been hypothesized to be involved in cognitive impairment due to sleep deprivation.
|
25542735 |
2015 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, dexamethasone protects against the two hit mediated cognitive impairment by lowering the pro-inflammatory factors (TNF-α/IL-1β) both in lungs and blood.
|
30026058 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inflammatory cytokine levels, including interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF) α, in the blood have been associated with cognitive impairment and decline.However, evidence has been mixed.
|
30256904 |
2019 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Early intervention with a small molecule inhibitor for tumor necrosis factor-α prevents cognitive deficits in a triple transgenic mouse model of Alzheimer's disease.
|
22632257 |
2012 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consistent with this, elevated systemic TNF-α is associated with more rapid cognitive decline over 6months in Alzheimer's disease patients.
|
27633985 |
2017 |
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The increase of TNF-α and IL-6 expression might trigger the disruption of BBB in the brain, which eventually caused cognitive impairment in the 8-week STZ rats.
|
29867440 |
2018 |
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
LPS caused a marked elevation in IL-1β and TNF-α levels both peripherally and in the brain, together with microglia activation (p < 0.05) and cognitive impairment.
|
31158431 |
2019 |