|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNFalpha) is a key inflammatory cytokine associated with cachexia.
|
17182869 |
2006 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.
|
16077938 |
2005 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
However, serum TNF-α was positively associated with serum FFA in the early- but not late-stage cachexia.
|
29338749 |
2018 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention.
|
17878525 |
2007 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The excessive levels of tumor necrosis factor-alpha (TNF)/cachectin reported in 50% of cancer patients exhibiting clinically active disease may therefore mediate, at least in part, the cachexia associated with malignancy.
|
7678547 |
1993 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The syndrome of cachexia associated with malignant diseases can be in part attributed to the effects of tumour necrosis factor alpha (TNFalpha) which itself is produced by a variety of tumour cells.
|
9594023 |
1998 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In this study, weight loss, body mass index, skeletal muscle index (SMI), serum carcinoembryonic antigen, serum tumor necrosis factor (TNF)-α, serum interleukin (IL)-6, serum high mobility group box (HMGB)-1, and SDS-soluble myosin light chain 1 (SDS-MYL1) of the psoas muscle were examined in 8 autopsied cases of death from colorectal cancer (CRC) as biomarkers of cachexia.
|
31707381 |
2019 |
|
Cachexia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI.
|
27897403 |
2017 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Etanercept blocks tumor necrosis factor α (TNF-α), a proinflammatory cytokine that plays a role in cancer-related cachexia and tumor growth.
|
23429495 |
2013 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
TNF-α is associated with obesity, but also with anorexia and cachexia.
|
26472017 |
2016 |
|
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue.
|
27900559 |
2017 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Inducible nitric oxide synthase (iNOS) has recently been shown to be an important mediator of TNFα-induced cachectic muscle loss, and studies suggest that it may also play a role in sarcopenia.
|
21832306 |
2011 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In addition, TNF-alpha mice displayed impaired healing of incisional and excisional skin wounds, compared with control animals, before the onset of cachexia.
|
8686743 |
1996 |
|
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II.
|
28161398 |
2017 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Because tumor necrosis factor alpha (TNF-alpha) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined.
|
11344085 |
2001 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that the evaluation of TNF/cachectin and LT production in lymphomas may help to elucidate the mechanisms of tumoral fever and cachexia.
|
2302463 |
1990 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3 ± 7.2 years).
|
21197447 |
2010 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
A number of pro-inflammatory cytokines, like interleukin-1 (IL-1), IL-6, tumor necrosis factor- alpha (TNF-α) may have important role in the pathological mechanisms of cachexia in cancer.
|
27919820 |
2017 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
However, from various studies it has become clear that the action of TNF can only be understood in the context of simultaneous presence of other cytokines, some of which have activities that are at the least equally important as TNF in bringing about cachexia.
|
9290087 |
1997 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Immunization with RTFP-2 also reduced the mortality of TNF-α induced cachexia from 56% to 28%.
|
22884682 |
2012 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Consequently, alcohol consumption neither affected cancer-associated cachexia nor decreased the survival of TNFα KO mice bearing cachectic cancer.
|
31657476 |
2020 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The basis for these interactions between TNF and IGF-1 is discussed with specific reference to clinical consequences for myofibre necrosis in DMD and also for the wasting (atrophy) of skeletal muscles that occurs in very old people and in cachexia associated with inflammatory disorders.
|
18215180 |
2008 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
It has further been suggested that TNF may play a role in the pathobiochemistry of CF cachexia, secondary to the localized inflammatory response in the lung or wider systemic activation of cells of the monocyte-macrophage series in response to endotoxin.
|
8217192 |
1993 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.
|
7538333 |
1995 |
|
Cachexia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate TNF-α -1031T/C SNP as a risk factor of cachexia in 62 HNC patients subjected to radiotherapy.
|
29802455 |
2018 |