|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Since tumor necrosis factor-alpha (TNF alpha) is elevated in cachexia-associated diseases, and chronic administration of TNF alpha induces cachexia in animal models, we assessed the regulation of albumin gene expression by TNF alpha in vivo.
|
2295699 |
1990 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that the evaluation of TNF/cachectin and LT production in lymphomas may help to elucidate the mechanisms of tumoral fever and cachexia.
|
2302463 |
1990 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The mouse/human chimeric monoclonal antibody cA2 neutralizes TNF in vitro and protects transgenic mice from cachexia and TNF lethality in vivo.
|
7538333 |
1995 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The excessive levels of tumor necrosis factor-alpha (TNF)/cachectin reported in 50% of cancer patients exhibiting clinically active disease may therefore mediate, at least in part, the cachexia associated with malignancy.
|
7678547 |
1993 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNF)-cachectin increases the expression of the human immunodeficiency virus (HIV), reverses the therapeutic efficacy of zidovudine (ZDV), and may contribute to the wasting syndrome.
|
8099612 |
1993 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
It has further been suggested that TNF may play a role in the pathobiochemistry of CF cachexia, secondary to the localized inflammatory response in the lung or wider systemic activation of cells of the monocyte-macrophage series in response to endotoxin.
|
8217192 |
1993 |
|
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Transgenic mice that express human TNF mRNA in T cells develop marked histologic and cellular changes locally in their lymphoid organs and a lethal wasting syndrome associated with widespread vascular thrombosis and tissue necrosis.
|
8345187 |
1993 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In addition, TNF-alpha mice displayed impaired healing of incisional and excisional skin wounds, compared with control animals, before the onset of cachexia.
|
8686743 |
1996 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
However, from various studies it has become clear that the action of TNF can only be understood in the context of simultaneous presence of other cytokines, some of which have activities that are at the least equally important as TNF in bringing about cachexia.
|
9290087 |
1997 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The syndrome of cachexia associated with malignant diseases can be in part attributed to the effects of tumour necrosis factor alpha (TNFalpha) which itself is produced by a variety of tumour cells.
|
9594023 |
1998 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Because tumor necrosis factor alpha (TNF-alpha) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined.
|
11344085 |
2001 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor alpha (TNF-alpha) appears to play a role in the cachexia and diabetes seen in patients with cancers.
|
12378118 |
2002 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Animals implanted with MCF-7IL-1 alpha cells were cachetic, which correlated with increased leptin serum levels but not other known cachexia-inducing cytokines such as IL-6, tumor necrosis factor, or interferon gamma.
|
14633625 |
2003 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.
|
16077938 |
2005 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNFalpha) is a key inflammatory cytokine associated with cachexia.
|
17182869 |
2006 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention.
|
17878525 |
2007 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The basis for these interactions between TNF and IGF-1 is discussed with specific reference to clinical consequences for myofibre necrosis in DMD and also for the wasting (atrophy) of skeletal muscles that occurs in very old people and in cachexia associated with inflammatory disorders.
|
18215180 |
2008 |
|
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that elevated TNF-alpha serum level may have clinical significance in the development of cachexia in PA patients.
|
19152246 |
2009 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3 ± 7.2 years).
|
21197447 |
2010 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Inducible nitric oxide synthase (iNOS) has recently been shown to be an important mediator of TNFα-induced cachectic muscle loss, and studies suggest that it may also play a role in sarcopenia.
|
21832306 |
2011 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Expression of a constitutively active mutant of Gα(i2) stimulated myotube growth and differentiation, effects that required the transcription factor NFAT (nuclear factor of activated T cells) and protein kinase C. In addition, expression of the constitutively active Gα(i2) mutant inhibited atrophy caused by the cachectic cytokine TNFα (tumor necrosis factor-α) by blocking an increase in the abundance of the mRNA encoding the E3 ubiquitin ligase MuRF1 (muscle ring finger 1).
|
22126963 |
2011 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Immunization with RTFP-2 also reduced the mortality of TNF-α induced cachexia from 56% to 28%.
|
22884682 |
2012 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Etanercept blocks tumor necrosis factor α (TNF-α), a proinflammatory cytokine that plays a role in cancer-related cachexia and tumor growth.
|
23429495 |
2013 |
|
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
TNF-α is associated with obesity, but also with anorexia and cachexia.
|
26472017 |
2016 |
|
Cachexia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI.
|
27897403 |
2017 |