Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Consequently, alcohol consumption neither affected cancer-associated cachexia nor decreased the survival of TNFα KO mice bearing cachectic cancer.
|
31657476 |
2020 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In this study, weight loss, body mass index, skeletal muscle index (SMI), serum carcinoembryonic antigen, serum tumor necrosis factor (TNF)-α, serum interleukin (IL)-6, serum high mobility group box (HMGB)-1, and SDS-soluble myosin light chain 1 (SDS-MYL1) of the psoas muscle were examined in 8 autopsied cases of death from colorectal cancer (CRC) as biomarkers of cachexia.
|
31707381 |
2019 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
DD therapy also further downregulated BALF ILs and cytokines including Jak-STAT (Janus kinases-signal transducer and activator of transcription proteins), TNFα (tumor necrosis factor-α), and T-cell receptor signaling pathways, cytokines involved in macrophage migration, eosinophil recruitment, humoral and adaptive immunity, neutrophil activation, and cachexia.
|
30965011 |
2019 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Among these, tumor necrosis factor alpha (TNFα) plays a relevant role in enhancing cancer risk, cancer growth, and cancer-associated cachexia.
|
30764482 |
2019 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
However, serum TNF-α was positively associated with serum FFA in the early- but not late-stage cachexia.
|
29338749 |
2018 |
Cachexia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
To investigate TNF-α -1031T/C SNP as a risk factor of cachexia in 62 HNC patients subjected to radiotherapy.
|
29802455 |
2018 |
Cachexia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI.
|
27897403 |
2017 |
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue.
|
27900559 |
2017 |
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II.
|
28161398 |
2017 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
A number of pro-inflammatory cytokines, like interleukin-1 (IL-1), IL-6, tumor necrosis factor- alpha (TNF-α) may have important role in the pathological mechanisms of cachexia in cancer.
|
27919820 |
2017 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
TNF-α is associated with obesity, but also with anorexia and cachexia.
|
26472017 |
2016 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Etanercept blocks tumor necrosis factor α (TNF-α), a proinflammatory cytokine that plays a role in cancer-related cachexia and tumor growth.
|
23429495 |
2013 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Immunization with RTFP-2 also reduced the mortality of TNF-α induced cachexia from 56% to 28%.
|
22884682 |
2012 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Inducible nitric oxide synthase (iNOS) has recently been shown to be an important mediator of TNFα-induced cachectic muscle loss, and studies suggest that it may also play a role in sarcopenia.
|
21832306 |
2011 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Expression of a constitutively active mutant of Gα(i2) stimulated myotube growth and differentiation, effects that required the transcription factor NFAT (nuclear factor of activated T cells) and protein kinase C. In addition, expression of the constitutively active Gα(i2) mutant inhibited atrophy caused by the cachectic cytokine TNFα (tumor necrosis factor-α) by blocking an increase in the abundance of the mRNA encoding the E3 ubiquitin ligase MuRF1 (muscle ring finger 1).
|
22126963 |
2011 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
We investigated AT expressions of interleukin (IL)-6, tumor necrosis factor (TNF)-α, CD68 (macrophage cell surface receptor), caspase-3, and Bax, and their relationships to the metabolic phenotype in nine cachectic, 12 normal-weight, 12 overweight, and 11 obese patients with COPD (age 62.3 ± 7.2 years).
|
21197447 |
2010 |
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that elevated TNF-alpha serum level may have clinical significance in the development of cachexia in PA patients.
|
19152246 |
2009 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The basis for these interactions between TNF and IGF-1 is discussed with specific reference to clinical consequences for myofibre necrosis in DMD and also for the wasting (atrophy) of skeletal muscles that occurs in very old people and in cachexia associated with inflammatory disorders.
|
18215180 |
2008 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention.
|
17878525 |
2007 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNFalpha) is a key inflammatory cytokine associated with cachexia.
|
17182869 |
2006 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.
|
16077938 |
2005 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Animals implanted with MCF-7IL-1 alpha cells were cachetic, which correlated with increased leptin serum levels but not other known cachexia-inducing cytokines such as IL-6, tumor necrosis factor, or interferon gamma.
|
14633625 |
2003 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor alpha (TNF-alpha) appears to play a role in the cachexia and diabetes seen in patients with cancers.
|
12378118 |
2002 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Because tumor necrosis factor alpha (TNF-alpha) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined.
|
11344085 |
2001 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The syndrome of cachexia associated with malignant diseases can be in part attributed to the effects of tumour necrosis factor alpha (TNFalpha) which itself is produced by a variety of tumour cells.
|
9594023 |
1998 |